Immunology 1

Front 1

talk about smallpox eradication

Back 1

-discovered by Jenner

Eradicated via vaccine
-used volunteer children with cowpox
-antigenically close enough
-begining of immunology

Contrevercial topic: should we keep it in a laboratory

officialy eradicated in 1979

See graph on 1/2-2

Front 2

Do vaccines work

Back 2

yes....smallpox and diptheria are completely erradicated.......other diseases are around 99% erradicated

Front 3

Graves Disease

Back 3

-hyperthyroidism
-Bulging eyes

Front 4

what do bubble boys lack

Back 4

-they have no immune system becasue they lack Adenosine Geaminase-breaks down purines

can also be an x-linked trait that targets the g-chain of IL molecules

The result is a near complete failure of the immune system to develop and function, with low or absent T cells and NK cells and non-functional B cells.

Front 5

Most important line of defense?

Back 5

skin

Front 6

talk about exterior defences

Back 6

1/5-1

Front 7

draw primary response vs. secondary response graph

Back 7

1/5-3

Front 8

what is the factor for something to be exposed a second time so that the immune system responds better?

Back 8

antigen must be immunologically close enough

Front 9

draw clonal selection and describe

Back 9

-Instead of going from 1 to 4, you go from 4 to 40

If it sees an antigen it will expand

1/6-1

Front 10

Innate versus adaptive immunity

humoral versus cellular immunity

(3 differences between each)

antigen and epitope definition

Back 10

1/6-2

Front 11

immune cell creation flow chart

Back 11

1
6-3

1
7-1

Front 12

Normal adult blood cell counts

Back 12

1
7-2

Front 13

Major lymphoid organs and tissues w location

Back 13

1
7-3

Front 14

a day in the life of a T cell

Back 14

1
8-2

Front 15

Lymph Node view and what is produced in each part

Back 15

1
8-3

Front 16

Primary lymphoid tissue

Back 16

where cells form and mature

Thymus-t cells
bone marrow- B cells

Front 17

Secondary Lymphoid Tissue

Back 17

where mature cells interact w pathogens and initiate a response

spleen
lymph nodes
tonsils

Front 18

Leukocytes with function

Back 18

Neutrophil: ingest and destroy invaders

Lymphocye and plasma cells (derivative): specific response, Ab production

monocyte and macrophage(becomes macrophage once in tissue): Ingest and destroy invaders, Ag presentation

Eosinophils: Destroy invaders, particularly Ab-coated parasites- Parasites and allergic response

Basophils and mast cells (tissue): Release chemicals that mediate inflammation and allergic response

Dendritic cells (not found in blood): recognize pathogens and activate other immune cells by antigen presentation

Front 19

APC types

Back 19

dendrytic cells
lymphocytes
macrophages

Front 20

cytotoxic cells types

Back 20

eosinophils
some lymphocytes

Front 21

lymphocyte types

Back 21

B cells> plasma cells (secrete Ab)

T cells >

NK cells