Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
42 Cards in this Set
- Front
- Back
|
Histamine
|
increase vasodilation and mucus
|
|
|
Prostiglandins
|
increase permeability and vasodilate
|
|
|
Leukotrienes
|
increase mucus and bronchoconstrict
|
|
|
Chemokines
|
attract cells to site
|
|
|
Platelet activating Factor
|
cause aggregation of inflammatory cells
chemotaxis, activate PMN |
|
|
Enzymatic Mediators
|
cell movement, damage, and repair of tissue
|
|
|
C3a, C4a
|
Inflammation response
increase vasodilation, permeability, phagocytic recruitment |
|
|
C3b
|
major player for opsinization
|
|
|
C5b
|
initiates MAC to aggregate C9
|
|
|
CD59
|
inhibits formation of CD5b and aggregation of C9
|
|
|
C1INH
|
destroys enzymatic activity of C1 proteins
|
|
|
• Decay accelerating factor (DAF)
|
CD55 -prevents the assembly of and causes dissociation of C3 convertase
|
|
|
C5a
|
C5a is the most potent chemoattractant for neutrophils
increases vasodilation and permiability anaphylatoxin |
|
|
Erythropoietin
|
erythrocytes
|
|
|
TNF
|
triggers apoptosis, Increased CAM, increase fever, increase cytokines
|
|
|
IL 1
|
Fever, activate endothelium (think increased CAM and attract neutrophils)
IL1 and TNF are very similar |
|
|
IL-2
|
Proliferation of T and B cells
also NKs |
|
|
IL-3
|
hematopoeitic growth factors
|
|
|
IL-4
|
Pro B cell and IgE formation
|
|
|
IL-5
|
Pro B cell, AB secretion, eosinophil activation
|
|
|
IL 6
|
Fever and acute phase response
|
|
|
IL-8
|
Chemotaxis, recruits neutrophils
|
|
|
What will cause septic shock
|
TNF alpha
|
|
|
IL-10
|
inhibits macrophage and dendritic cells
|
|
|
IL-12
|
released by macrophage and causes differentiation of T cells, increases NK toxins, anti-angiogenic
STIMULATES INF GAMMA AND TH1 PRODUCTION |
|
|
IL 17
|
Attracts neutrophils
released by TH17 from CD4 cells |
|
|
INF Alpha Type I
|
anti-viral
|
|
|
INF Beta Type I
|
anti-viral
|
|
|
INF Gamma
|
Increase macrophage activity and NK
IgG isotype switch B and MHC production |
|
|
G-CSF
|
Granulocytosis
|
|
|
M-CSF
|
Monocyte and Macrophage production
|
|
|
GM-CSF
|
Monocyte and granulocyte production
|
|
|
TGF-B
|
inhibitory of macrophages and inflammatory response
forms IgA |
|
|
CD3
|
Signal transduction by TCR
|
|
|
CD4 (what does it bind)
|
signaling and adhesion co-receptor, binds class II MHC (remember exogenous)
|
|
|
CD8 (what does it bind)
|
signaling and adhesion bind to Class I MHC (remember intracellular insult like virus)
|
|
|
CD28
|
Binds B7-1 (CD80) and B7-2 (CD86) as co-stimulator
|
|
|
CD40
|
found on both T and B cell, leads to full activation of B cell
|
|
|
CD80
|
B7-1 on APC (specifically dendritic cell) binds CD28 to turn T cell on
|
|
|
CD86
|
B7-2 on APC (specifically dendritic cell) binds CD28 to turn T cell on
|
|
|
CD152
|
CTLA-4 binds to CD28 to turn T cells OFF
|
|
|
CD154
|
CD40 ligand used to bind the B to T cells
|
