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26 Cards in this Set

  • Front
  • Back
What are the components of the B cell co-receptor?
CD19 (the signaling component)
CR2
CD81
What are the 2 complement receptors of B cells
CR1 and CR2
CR2 of the B cell binds to...
C3d on the pathogen surface
what causes BCR and the BCR co-receptor to be juxtaposed
the interaction between CR2 on the B cell with C3d on the pathogen surface
Which antibody is associated with epithelial surfaces
IgE
Which antibody predominates in mucosal secretions
IgA
Which antibody has the ability to cross the placenta
IgG
What structure portion of Ig determines its anatomical location and function
The Fc portion made of heavy chains only
IgG is transported to extracellular spaces via
FcRn or the Brambel receptor
The receptor FcRn transports IgG from the bloodstream into
the extracellular spaces
Transcytosis of dimeric IgA antibody across epithelia is mediated by
the poly-Ig receptor
what antibody protects mucosal surfaces
dimeric IgA
Which antibody is a major constituent of breast milk
dimeric IgA
Which isotypes are the most effective at activating the compliment cascade
IgG3 and IgM
What is a drawback of IgM
its large size
ADCC (antibody-dependent cell mediated cytotoxicity) involves
NK cells
NK cell have what type of Fc receptors
FcyRIII
FcyRI is a high affinity receptor for
IgG1 and IgG3
What part of the FcyRI receptor activates the signaling cascade
the y chain
What Fc receptor type is found on cells of myeloid lineage
FcyRI
What is different about the structure of Inhibitory Fc receptors
They have ITIMs on their cytoplasmic domains

ITIMs are immunoreceptor tyrosine-based inhibitory motifs
Which antibody isotype is important in the allergic response
IgE
IgE binds which Fc receptor
the Fc(epsilon) receptor
The Fc epsilon receptor is found on which cells
mast cells, basophils, and eosinophils
During pregnancy what receptor transports protective IgG from the mothers blood to the baby
FcRn
What characterizes hyper IgM syndrome
A lack of CD40 ligand expression on T cells

If you dont have the help of T cells the B cells can not undergo isotype switching and end up with an abundance of IgM only