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26 Cards in this Set
- Front
- Back
What are the components of the B cell co-receptor?
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CD19 (the signaling component)
CR2 CD81 |
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What are the 2 complement receptors of B cells
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CR1 and CR2
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CR2 of the B cell binds to...
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C3d on the pathogen surface
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what causes BCR and the BCR co-receptor to be juxtaposed
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the interaction between CR2 on the B cell with C3d on the pathogen surface
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Which antibody is associated with epithelial surfaces
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IgE
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Which antibody predominates in mucosal secretions
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IgA
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Which antibody has the ability to cross the placenta
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IgG
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What structure portion of Ig determines its anatomical location and function
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The Fc portion made of heavy chains only
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IgG is transported to extracellular spaces via
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FcRn or the Brambel receptor
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The receptor FcRn transports IgG from the bloodstream into
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the extracellular spaces
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Transcytosis of dimeric IgA antibody across epithelia is mediated by
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the poly-Ig receptor
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what antibody protects mucosal surfaces
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dimeric IgA
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Which antibody is a major constituent of breast milk
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dimeric IgA
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Which isotypes are the most effective at activating the compliment cascade
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IgG3 and IgM
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What is a drawback of IgM
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its large size
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ADCC (antibody-dependent cell mediated cytotoxicity) involves
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NK cells
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NK cell have what type of Fc receptors
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FcyRIII
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FcyRI is a high affinity receptor for
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IgG1 and IgG3
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What part of the FcyRI receptor activates the signaling cascade
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the y chain
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What Fc receptor type is found on cells of myeloid lineage
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FcyRI
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What is different about the structure of Inhibitory Fc receptors
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They have ITIMs on their cytoplasmic domains
ITIMs are immunoreceptor tyrosine-based inhibitory motifs |
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Which antibody isotype is important in the allergic response
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IgE
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IgE binds which Fc receptor
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the Fc(epsilon) receptor
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The Fc epsilon receptor is found on which cells
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mast cells, basophils, and eosinophils
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During pregnancy what receptor transports protective IgG from the mothers blood to the baby
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FcRn
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What characterizes hyper IgM syndrome
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A lack of CD40 ligand expression on T cells
If you dont have the help of T cells the B cells can not undergo isotype switching and end up with an abundance of IgM only |