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9 Cards in this Set
- Front
- Back
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genes for T cell and B cell |
B cells - PAX -5 gene T cells - NOTCH gene CD 4 suppressor/regulatory T cell - FOX P3 gene |
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CD markers |
Stem cells - CD 34 Pan B cell - CD 19 Pan T cell - CD 3 FAS ligand - CD 95 PECAM 1 - CD 31 Selectins - CD 62 Monocyte-macrophage- CD 14 (best), 13, 15, 33 Memory T cell -CD 45 RO Myeloid marker- CD 117 (MPO>>CD 117) c kit also CD 117 Glial tumour - CD 133 EBV/complement receptor type 2 (CR 2) - CD 21 CD 71 : a. Glycophorin b. Transferrin receptor/ erythroblast c. IgA nephropathy/Mesangial cells Costimulatory molecules for T cell - CD 80 (B7.1), CD 86 (B7.2) LCA (Leucocyte common Antigen) - CD 45 CALLA (Common acute lymphoblastic leukemia antigen) - CD 10 CD 15 CD 30 - classical H Lymphoma |
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TH 1 |
1. stimulated by IFN Y 2. releases IFN Y and IL 2 3. Stimulates macrophages involved in: ~ granuloma formation ~ Intracellular killing ~ Type IV HS ~ GVHD |
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TH 2 |
1. Stimulated by a. IL 4 - mast cell b. IL 5 - Eosinophils c. IL 6- Ig E d. IL 13 Involved in: ~ Type I HS ~ Ig E release ~ Parasite killing |
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TH 17 |
Stimulated by IL 1,6, TGF B Releases IL 17 - Severe inflammation Involved in : ~ Autoimmune reactions psoriasis Multiple sclerosis Rheumatoid arthritis Fungal killing |
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MHC |
I - nucleated cells. platelets no RBC III - C2 C4 Properdin factor B, TNF A, Heat shock protein II - APC: { dendritic cells, langerhans cells, macrophages, B cells } all these have I + II because they're also nucleated |
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SLE - antibodies |
Ro (SS-A) - 1. Cong heart block 2. Myocarditis 3. Shrinking lung syndrome 4. Photosensitivity Lupus psychosis - anti ribosomal P antibody RaynaUds - anti U1 ribonucleoprotein ab Most specific - Anti sm >anti ds DNA Most sensitive - ANA Best correlation with prognosis - anti ds DNA Most sensitive and specific overall - anti ds DNA |
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SLE immuno fluorescence patterns |
1. Speckled - mc type, green background - Anti sm ab 2. Diffuse - histone ab 3. Centromere - anti Centromere ab (scleroderma) black background with green specks 4. Rim - ds DNA ab 5. Nucleolar - scleroderma and SLE |
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Other auto antibodies |
-Anti Jo 1/anti histidyl tRNA synthetase - inflammatory myositis with mechanic hands and ILD -Anti mi 2 ab - dermatomyositis -anti p 140/ p 150 - dermatomyositis a/w paraneoplastic syndrome /juvenile Dematomyositis -anti topoisomerase ab/Scl 70- systemic sclerosis (scleroderma) -anti Centromere ab - CREST syndrome /localized scleroderma -anti U1 ribonucleoprotein - MCTD, and RaynaUds phenomenon |
