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12 Cards in this Set

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central lymphoid organs

vs

peripheral lymphoid organs
central=where immune cells are made
*thymus
*BM

peripheral=where immunocompetency is expressed
*spleen
*LN
*tonsils
*Peyer's patches (sm int)
*mucosa
penetrability vs. invasiness

of parasite
penetrability=ab of parasite to gain access to host

invasiveness=ab of prasite to enter ("invade") tissues
CD markers on all peripheral T cells
CD 2 & 3
Th1 cells secrete
IL2
IFN-gamma
Th2 cells secrete
IL 4, 5, 6, 10, 13
VDJ recombination
-in what cells and in what stage does it happen
B cells

pro-B cell: D-J recomb

pre-B cell:
V-DJ recomb,
then VDJ-C

note:
J=Joining
D=diversity
V=Variable
C=mu Constant (C) region gene
epitope
-AKA
-desc
AKA ligand
AKA Antigenic-determinant

short sequence of aa or sugars on an Ag that combines w/hypervariable reactive site on Ig

-the epitope is usually repeated several times ("valence"=# of times repeated)
hapten
-part of Ag that contains epitope
-reacts specifically w/its Ig
superantigens
certain retroviruses and bacterial toxins (Staph enterotoxins & Toxic Shock Syndrome toxin) can link multiple T cells (@ TCR V-Beta sites) to MHCII's of APC's

-since this linking occurs independently of specific peptide-binding sites
==>many APC's activated
==>toxic shock
Streptococcal antigens
-group-specific carbohydrates
-type-specific M proteins
-streptolysin O
Salmonella antigens
-O Ag (LPS)
-H (flagellar) Ag
-virulence (Vi) Ag
-pili
-several exotoxins
HIV antigens
glycoproteins (gp160, gp120, gp41): "160-120 ~41"

enzymes (eg reverse transcriptase)