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12 Cards in this Set
- Front
- Back
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central lymphoid organs
vs peripheral lymphoid organs |
central=where immune cells are made
*thymus *BM peripheral=where immunocompetency is expressed *spleen *LN *tonsils *Peyer's patches (sm int) *mucosa |
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penetrability vs. invasiness
of parasite |
penetrability=ab of parasite to gain access to host
invasiveness=ab of prasite to enter ("invade") tissues |
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CD markers on all peripheral T cells
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CD 2 & 3
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Th1 cells secrete
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IL2
IFN-gamma |
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Th2 cells secrete
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IL 4, 5, 6, 10, 13
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VDJ recombination
-in what cells and in what stage does it happen |
B cells
pro-B cell: D-J recomb pre-B cell: V-DJ recomb, then VDJ-C note: J=Joining D=diversity V=Variable C=mu Constant (C) region gene |
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epitope
-AKA -desc |
AKA ligand
AKA Antigenic-determinant short sequence of aa or sugars on an Ag that combines w/hypervariable reactive site on Ig -the epitope is usually repeated several times ("valence"=# of times repeated) |
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hapten
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-part of Ag that contains epitope
-reacts specifically w/its Ig |
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superantigens
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certain retroviruses and bacterial toxins (Staph enterotoxins & Toxic Shock Syndrome toxin) can link multiple T cells (@ TCR V-Beta sites) to MHCII's of APC's
-since this linking occurs independently of specific peptide-binding sites ==>many APC's activated ==>toxic shock |
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Streptococcal antigens
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-group-specific carbohydrates
-type-specific M proteins -streptolysin O |
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Salmonella antigens
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-O Ag (LPS)
-H (flagellar) Ag -virulence (Vi) Ag -pili -several exotoxins |
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HIV antigens
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glycoproteins (gp160, gp120, gp41): "160-120 ~41"
enzymes (eg reverse transcriptase) |
