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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Nucleoside Reverse Transcriptase Inhibitors (NRTI)
*become part of HIV's DNA and causes damage |
-Zidovudine (AZT, Retrovir)
s/e= anermia, bone marrow suppression, peripheral neuropathy, GI, pancreatitis |
n/i= check labs, call doc if WBC dec- do not give drug : poses a risk to T Lymphocytes
*AZT can be given to pregnant woman 14-34 weeks |
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Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
*affects enzyme necessary for conversion of HIV RNA into HIV DNA |
-Nevirapine (NVP)
s/e= rashes, elevated transaminases, GI, CNS |
n/i= liver: check ast, alt, if increasing liver damage is occurring
*safety is a big concern |
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Protease Inhibitor (PI)
*affect enzyme required for splitting of virus into particles that infect new CD4-T4 cells |
-Nelfinavir (Viracept)
s/e= GI, elevated transaminases, hyperglycemia, fal maldistribution, lipid abnormalities |
n/i= check ast/alt, need to monitor blood sugar at home- can cause insulin resistance (if bs is increasing and not a diabetic)
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Entry Inhibitors
*acts during the attatchment stage of HIV cycle |
Enfuvirtide (T20) - given SQ
s/e= local injection site reactions |
n/i= given to people not GI tolerating with other meds, rotate sites!!
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Integrase Inhibitors
* inhibits insertion of HIV into human DNA |
Raltegravir
s/e= GI |
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CCR5 Antagonist
*prevents HIV entry into CD4+ cell |
Maraviroc
s/e= GI, fever, diziness, elevated liver/ cardiac enzymes |
n/i= check ast/alt and cardiac enzymes because this drug can cause damage to the liver and to the heart
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PCP
* also given prophylactic T Cell Count < 200 |
TMP-SMZ (Bactrim/Septra)
s/e= rashes |
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MAC
*T cell count < 50 prophylactic |
Biaxin, Zithromax
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*biaxin can be given IVPB
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TB
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Isoniazid, Rifampin
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Oral Candidiasis
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Nystantin
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Meningitis ( cryptococcus neoformans)
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Amphotericin B (antifungal)
s/e, very severe= high fever, hypotension, tachypnea, generalized weakness |
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Cytomegalovirus Retinitis (CMV)
* prophylaxis TX T cell count < 50 |
Ganciclovir - severe neutropenia (must not be taking AZT)
Foscarnet- Renal failure, life threatening electrolyte imbalances |
* once have this, need to stay on these drugs forever!!
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Herpes Simplex, Herpes Zoster
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Acyclovir
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shortens disease length, but is not a cure!
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