Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
78 Cards in this Set
- Front
- Back
|
Which drug can cause death if you restart it?
|
Abacavir (Ziagen ABC)
|
|
|
Which NRTI can cause a hypersensitivity reaction?
|
Abacavir (Ziagen) ABC
|
|
|
How should you take didanosine?
W/ IND? w/ NFV? |
1/2 hour before or 2hrs after meals
Take Indinivir(Crixivan) 1 hr before ddi, Take ddi 1 hr before Nelfinavir ( Viracept) |
|
|
Which three NRTI's can cause pancreatitis, PN, and lactic acidosis?
|
The three d's
ddi (didanosine), d4T (stavudine), ddC (zalcitabine) |
|
|
Which drug should not be coupled with ddI in pregnancy? why?
|
Stavudine (d4T increased risk of lactic acidosis and liver damage
|
|
|
Which NRTI does not require renal dosing?
|
Abacavir Ziagen
|
|
|
How is emtricitabine administered? QD vs. BID? w/ or w/o food?
|
Emtriva is given QD with food
|
|
|
Major SE of Emtriva
|
rash, skin discoloration on hands and feet
|
|
|
Which NRTI drugs should not be used together?
|
lamivudine (epivir) and emtricitabine
stavudine + didanosine in pregnancy zidovudine (retrovir) + stavudine (Zerit) both require thymidine for activation |
|
|
NRTI class toxicities
|
hepatic steatosis & lactic acidosis
|
|
|
Major SE of Epivir?
|
lamivudine --> neuropathy
|
|
|
In a patient receiving PCP treatment w/ TMP-SMX what HIV drugs will be affected?
|
Increased 3tc
AZT --> increased risk of hematologic toxicities |
|
|
Major SE of Stavudine?
|
PN & pancreatitis
|
|
|
Which drugs increase risk of PN with zalcitabine?
|
amphoB, foscarnet, AG
|
|
|
If a patient is receiving pentamadine IV for PCP which drug will increase risk for pancreatitis?
|
zalcitabine DDC HIVID
|
|
|
Zalcitabine should be separated in dosing from?
|
mg/Al antacids by 2hrs
|
|
|
AZT major se?
|
hematologic (granulocytopenia, anemia), GI
increased risk with ganciclovir, amphob, dapsone, 5FC (flucytosine), primaquine, pyrimethamine, sulfadiazine, TMP/SMX, trimetrexate, chemo |
|
|
Combivir
|
lamivudine/zidovudine
|
|
|
Truvada
|
tenofovir/emtricitabine
dont give if Clcr < 30 |
|
|
Epzicom
|
Abacavir/lamivudine
dont give if CLcr < 50 |
|
|
Trizivir
|
abacavir/lamivudine/zidovudine
|
|
|
Which NRTI should be given with a high fat meal?
|
Tenofovir (Viread) TDF
|
|
|
Which NRTI can cause Fanconi's syndrome?
|
Renal toxicity with Tenofovir (Viread)
|
|
|
If tenofovir is given with atazanavir (reyataz) what should be done?
|
Boost reyataz
|
|
|
Tenofovir should be separated from what when dosing?
|
Ddi
|
|
|
Atripla
|
truvada + efavirenz
|
|
|
what is the class toxicity of NNRTI's?
|
Rash and hepatotoxicity
|
|
|
Which HIV med causes abnormal dreams?
|
Efavirenz (Sustiva)
|
|
|
Which NNRTI should be taken on an empty stomach?
|
Efavirenz (Sustiva)
|
|
|
Which HIV drug is an autoinducer?
|
Nevirapine (Viramune) BID
|
|
|
What are the side effects of Sustiva?
|
rash, CNS (dizziness), false cannabinoid test, abnormal dreams
|
|
|
Nevirapine (Viramune) SE?
|
rash, symptomatic hepatitis including fatal hepatic necrosis
|
|
|
Delavirdine (Rescriptor) SE?
|
rash, increased LFT's
|
|
|
Which NNRTI is CI in pregnancy?
|
Efavirenz (Sustiva)
|
|
|
Kaletra
|
lopinavir/ritonavir
|
|
|
What is the MOA of PI's?
|
inhibit protease prevents cleavage of HIV polyproteins inducing formation of immature non-infectious protein particles
|
|
|
Which PI's should not be taken with food?
|
amprenavir (Agenerase)APV and indinavir (Crixivan IDV)
|
|
|
Agenerase should not be combined with what?
|
Fosamprenavir (Lexiva)
|
|
|
Which PI's should be refrigerated?
|
lopinavir/ritonavir (kaletra), ritonavir (norvir)RTV, and Saquinavir soft gel caps (SQV Fortovase)
|
|
|
What are the class toxicities?
7 |
1. lipodystrophy
2. hyperglycemia 3. hyperlipidemia 4. hyperTG 5. bleeding in hemophiliacs 6t. osteonecrosis and avascular necrosis of the hips 7. osteopenia/osteoporosis |
|
|
Reyataz SE?
|
Atazanavir
hyperbilirubinemia & prolonged PR interval |
|
|
Indinavir IDV recipients must receive 1.5L water daily why?
|
nephrolithiasis
|
|
|
Viracept SE?
|
nelfinavir NFV
diarrhea |
|
|
Ritonavir (Norvir) SE?
|
nausea- throw up first 2 weeks
|
|
|
Which PI has less lipid abnormalities?
|
atazanavir (Reyataz) ATV
boosted with tenofovir get it back |
|
|
How long are ritonavir gel caps stable at room temperature?
|
1 month
|
|
|
How long are kaletra caps stable at room temperature?
|
2 months
|
|
|
Brand name of Saquinavir HGC? SGC?
|
Invirase- hGC
Fortovase- SGC |
|
|
Saquinavir is boosted with what?
|
Ritonavir
|
|
|
Saquinavir SE?
|
GI intolerance, hypoglycemia, lipodystrophy
|
|
|
Which PI's do u need to avoid antacids?
|
Indinavir, Amprenavir
|
|
|
T20 is
|
enfuvirtide (Fuzeon)
|
|
|
Injection sites of fuzeon?
|
upper arm, anterior thigh, or abdomen,
inject in circle- reactions |
|
|
Once reconstituted how long is fuzeon stable?
|
Keep in fridge stable for 24 hrs
|
|
|
Selzentry is indicated in what patients?
|
Maraviroc
CCR5tropic treatment experienced patients |
|
|
Aptivus brand
SE |
Tipranavir
Rash, liver toxicity and fatal intracranial hemorrhage |
|
|
Darunavir (Prezista) should not be coadministered with ?
|
Kaletra or saquinavir
|
|
|
MOA of Fuzeon?
|
bind to gp41 on HIV surface inhibiting binding of CD4 cell
|
|
|
Lexiva?
|
fosamprenavir f-APV
|
|
|
Agenerase SE? Lexiva SE?
|
rash- its a sulfonamide
|
|
|
Raltegravir
|
Isentress
|
|
|
Isentress DI with_________
|
rifampin
|
|
|
Available as suspension?
|
nevirapine ( viramune)
|
|
|
Available as oral solution/syrup
|
NRTI- lamivudine, abacavir, didanosine,
PI- kaletra, amprenavir, nelfinavir, ritonavir |
|
|
When do you treat for PCP?
|
CD4 <200
PCP tx covers toxoplasmosis prophylaxis |
|
|
DOC for PCP
|
Bactrim DS po qd
|
|
|
Atovaquone
|
Mepron
PCP |
|
|
NebuPent/ Pentam 300
|
pentamadine PCP
neb, injection |
|
|
TMP + dapsone
|
for PCP
|
|
|
Clindamycin + __________
|
primaquine
for PCP |
|
|
Trimetrexate + folinic acid
brand name of tri? |
NeuTrexin
|
|
|
When do you treat for MAC?
|
below 50 CD4
|
|
|
DOC for MAC?
|
azithromycin 1200mg po q week
|
|
|
Ganciclovir is CI for CMV retinitis when?
|
ANC <500, PLT <25,000
|
|
|
Ganciclovir caps
|
Cytovene
|
|
|
Ganciclovir intravitreal implant
|
Vitrasert
|
|
|
How should ganciclovir Inject be prepared?
|
vertical flow hood with sterile water
|
|
|
Which combo with ddi is not recommended due to early virologic failures?
|
tenofovir Viread TDF
|
