Histology - Muscle And Nerve (Week 3)

Front 1

EPIMYSIUM

Back 1

DEEP FASCIA, DENSE CONNECTIVE TISSUE.

Front 2

MUSCLE FIBER

Back 2

SYNONYMOUS WITH CELL....LONG MULTINUCLEATED CELLS SURROUNDED BY A CONTINUOUS PLASMA MEMBRANE. AKA MYOFIBRIL.

Front 3

ENDOMYSIUM

Back 3

DELICATE CONNECTIVE TISSUE THAT SURROUNDS INDIVIDUAL MUSCLE CELLS.

Front 4

PERIMYSIUM

Back 4

CONNECTIVE TISSUE THAT SURROUNDS A GROUP OF MUSCLE FIBERS (FASCICLE).

Front 5

FASCICLE

Back 5

GROUP OF MUSCLE CELLS

Front 6

FUNCTION OF EPIMYSIUM, PERIMYSIUM AND ENDOMYSIUM

Back 6

PROTECTS CELLS AND PROVIDE SOME RESTING TENSION IN MUSCLE.

Front 7

SARCOMERE

Back 7

BASIC FUNCTIONAL UNIT OF THE CELL. MEASURED FROM Z UNIT TO Z UNIT.

Front 8

I-BAND

Back 8

(isotropic in polarized light) – thin
filaments only.

Front 9

SARCOMERE GOES FROM....

Back 9

Z-LINE TO Z-LINE

Front 10

THIN FILAMENT

Back 10

PROTEIN CALLED ACTIN - GLOBULAR UNITS OF G-ACTIN ASSOCIATE TO FORM A FILAMENT - F - ACTIN. EACH GLOBULAR HAS A BINDING SITE OF FOR MYOSIN

Front 11

TROPOMYOSIN

Back 11

PROTEIN ASSOCIATED WITH ACTIN AND TROPONIN COMPLEX IN THICK FILAMENTS

Front 12

MYOCIN

Back 12

HOMODIMER OF MYOSIN HEAVY CHAINS AND 2 ASSOCIATED MYOSIN LIGHT CHAINS. MOLECULE HAS A HEAD, TAIL AND HINGE REGION. STRUCTURAL PROTEIN AND AN ENZYME.

Front 13

HEAD OF MYOCYN

Back 13

ENZYME BINDS AND HYDROLYZES ATP TO ADP AND INORGANIC PHOSPHATE.

Front 14

BINDING OF ATP IN MYOCYN HEAD

Back 14

CAUSES MOVEMENT AT THE HINGE JOINT OFTHE MOLECULE. INCREASES ANGLE OF HINGE JOINT.

Front 15

THICK FILAMENT

Back 15

MYOSIN PROTEINS WITH TAILS TOGETHER AND HEADS STICKING OUT.

Front 16

TITIN

Back 16

SPING LIKE ACCESSORY PROTEIN ASSOCIATED WITH THIN FILAMENT.

Front 17

NEBULIN

Back 17

ACCESSORY PROTEIN IN THICK FILAMENT - ANCHORS THIN FILAMENT TO Z DISC

Front 18

Z DISC

Back 18

SERVES TO ANCHOR THIN FILIMENTS

Front 19

3 BINDING COMPONENTS OF TROPONIN COMPLEX

Back 19

ACTIN, CALCIUM AND TROPOMYOCIN

Front 20

MICROGRAPH OF MUSCLE AT REST

Back 20

...

Front 21

CHANGE IN CA CONCENTRATION IN THE CYTOPLASM

Back 21

10-7 TO 10-5

Front 22

CROSS BRIDGE CYCLE

Back 22

TAKES PLACE 1000S OF TIME PER CONTRACTION.

Front 23

AXON TERMINALS GO TO...

Back 23

INFOLDINGS OF THE SARCOLEMMA CALLED SYNAPTIC CLEFTS.

Front 24

MOTOR END PLATE

Back 24

.....

Front 25

SYNAPTIC CLEFT

Back 25

....

Front 26

ACETYLCHOLINESTERASE

Back 26

DEGRADE ACH IN SYNAPTIC CLEFT. ACH IS THE NEUROTRANSMITTER IN SKELETAL MUSCLE.

Front 27

MOTOR UNIT

Back 27

AXON AND ALL FIBERS THAT IT INNERVATE - NUMBER OF FIBERS VARIES BASED SIZE OF MUSCLE. SMALL MOTOR UNITS ARE FINE MOTOR USE.

Front 28

MUSCLE SPINDLES

Back 28

IMBEDDED IN MUSCLE FIBERS. SENSE SUDDEN STRETCH IN THE MUSCLE AND TRIGGER A REFLEX ARC.

Front 29

GOLGI TENDON ORGANS

Back 29

SESORY NEURONS NEAR MUSCLE, TENDON JUNCTION. PREVENTS OVER CONTRACTION OF CERTAIN MUSCLES.

Front 30

ANATOMY OF THE NEURON

Back 30

Front 31

MULTIPOLAR NEURON

Back 31

Front 32

BIPOLAR

Back 32

Front 33

UNIPOLAR/PSEUDOUNIPOLAR

Back 33

Front 34

ASTROCYTES

Back 34

REGULATE LOCAL BLOOD FLOW IN THE CNS AND REGULATE MICRO ENVIRONMENT AROUND NEURONS, REGULATE NEUROTRANSMITTERS AND FORM SCAR TISSUE IN RESPONSE TO INJURY.

Front 35

MICORGLIA

Back 35

IMMUNE FUNCTION IN CNS. ONLY IN THE BRAIN. LOOKS LIKE A MACROPHAGE WHEN NOT UNDER ATTACK. PICTURE

Front 36

EPENDYMAL CELLS.

Back 36

EPITHELIAL CELLS WITH CILLIA ON SURFACE. MOVE CSF.

Front 37

ALIGODENDROCYTES

Back 37

CNS CELLS THAT CREATE MYLEN SHEATH AROUND AXONS IN CNS.

Front 38

SCHWANN CELLS

Back 38

MYLIN SHEATH IN PNS.

Front 39

SATELITE CELLS.

Back 39

Front 40

NERVES OF PNS

Back 40

ALL CELLS HAVE SCHWANN CELLS BUT NOT ALL ARE MYLINATED. PICTURE. WITHIN A GIVEN NERVE CAN HAVE BOTH TYPES.

Front 41

ORGANIZATION OF PERIPHERAL NERVES

Back 41

Front 42

LONGITUDINAL SECTION OF SLIDE.

Back 42

LAST SLIDE. SCHWANN CELLS VS FIBROBLASTS.

Front 43

SACROLEMMA

Back 43

CELL MEMBRANE OF MUSCLE CELLS. RUNS THE FULL LENGTH OF THE CELL. RECEIVES AND CONDUCTS STIMULI. SURROUNDED BY BASAL LAMINA AND ASSOCIATED WITH SATELLITE CELLS.

Front 44

TRANSVERSE TUBULES

Back 44

FINGER LIKE PROJECTIONS OF THE SARCOLEMMA INTO THE CYTOPLASM.

Front 45

SARCOPLASMIC RETICULUM

Back 45

MEMBRANEOUS SAC FUNCTIONING AS CALCIUM STORAGE SITES.

Front 46

TRANSVERSE TUBULES (T-TUBULES)

Back 46

FINGER LIKE PROJECTION (DEEP INVAGINATIONS) OF SACROLEMMA INTO CYTOPLASM. ONLY FOUND IN SKELETAL AND CARDIAC MUSCLE. ALLOW DEPOLARIZATION TO QUICKLY PENETRATE THE INSIDE OF THE CELL.

Front 47

A BAND

Back 47

(anisotropic in
polarized light) – thick and
thin filaments

Front 48

H-BAND

Back 48

thick filaments only

Front 49

TITIN

Back 49

ELASTIC PROTEIN THAT POSITIONS THE THICK FILAMENT IN THE SARCOMERE

Front 50

NEBULIN

Back 50

ANCHORS THE THING FILAMENT TO THE Z-DISC.

Front 51

TnT

Back 51

Tropomyosin-binding subunit which regulates the interaction of troponin complex with thin filaments.

Front 52

TnI

Back 52

Inhibits ATP-ase activity of acto-myosin.

Front 53

TnC

Back 53

Ca2+ - binding subunit, playing the main role in Ca2+ dependent regulation of muscle contraction

Front 54

MICROGRAPH OF CONTRACTED MUSCLE

Back 54

Front 55

ROLL OF CALCIUM IN MUSCLE CONTRACTION

Back 55

Front 56

NEURON CELL BODY

Back 56

...

Front 57

NEURON DENDRITES

Back 57

...

Front 58

NEURON AXON

Back 58

....

Front 59

NERVE CELLS OF PNS

Back 59

...

Front 60

MICROGRAPH OF NERVE CELLS IN PNS

Back 60

....

Front 61

CROSS SECTION OF PNS NERVE

Back 61