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57 Cards in this Set
- Front
- Back
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causes of xanthogranulomatous pyelonephritis
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- stone obstruction
- uti: e coli and proteus |
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what
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metanephric adenoma (adults, counterpart to Wilms in kids), benign
near solid looking, orderly array of tubules, can see psammoma bodies |
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what
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oncocytoma - on micro can have tubules within a paucicellular stroma
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nonsporadic causes of clear cell RCC
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VHL disease, APKD, acquired cystic kidney disease (long-term hemodialysis)
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putative cell of origin clear cell RCC
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Proximal convoluted tubules
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stain chromophobe rcc
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hale's colloidal iron
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cf gross of chromophobe rcc to oncocytoma
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same exc oncocytoma with central scar
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em chromophobe
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microvescles some of which are mt
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rcc with better prognosis than conventional
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pap rcc, chromophobe rcc
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rcc with worse prognosis
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sarcomatoid
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see medullary ca of kidney think
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sickle cell, young black males, poor prognosis
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clues to medullary ca microscopically
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- high grade nuclei
- centered on medulla |
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what
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collecting duct ca
Cytoplasmic and intraluminal mucin Hobnail cells centered on medulla partially cystic, can have variable growth patterns desmoplasia |
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what tumor
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JGA
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hypokalemia
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JGA tumor, benign, hyperreninism
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what, ihc, em
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angiomyolipoma
mature fat, thickwalled vessels, smooth muscle HMB45, actin EM: premelanosomes |
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pecoma family
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Angiomyolipoma
• Lymphangioleiomyomatosis • Clear cell sugar tumor of lung • Clear cell myomelanocytic tumor of the falciform ligament* all assoc with TS except last one |
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a michaelis gutman body is...
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lysosomes containing bacterial degradation products
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alt name for mesonephric adenoma
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nephrogenic adenoma - not true neoplasm - reaction to injury
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alt name for nephrogenic adenoma
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mesonephric adenoma - not true neoplasm -reaction to injury
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mass on posterior wall/dome of bladder, young woman
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think endocervicosis
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what
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BK virus, SV40 family, DNA viruses
decoy cells (shown) and comet cells (short cytoplasmic tails) |
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fish probes for urovysion
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chromosomes 3, 7, 17, and the 9p21 locus
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adenoca of bladder association
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exstrophy, urachal remnants
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what
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schistosomiasis, scca bladder
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hypercalcemia and SIADH
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small cell undifferentiated ca of bladder
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when see basal cell hyperplasia
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post radiation or hormone deprivation
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stains/ihc for mucinous metaplasia
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PSA and PAP –ve
PAS, mucicarmine and Alcian blue + |
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what is atypical adenomatous hyperplasia
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no prominent nuclei, patchy basal layer otherwise can mimic ca
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Xanthoma of prostate
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CD68+ cell aggregates
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criteria for ASAP
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3 or more glands to call ca
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what, where, stains
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prostatic large duct ca, (aka endometrioid ca), resembles endometrium; mass veromontanum
PSA, PAP staining |
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know this one, male GU - where, what, association
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epidydimis, papillary cystadenoma, VHL!!!!!!
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clinical setting for malignant mesothelioma in GU region
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recurrent hydroceles,
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strange/seemingly unique staining for malignant meso of GU tract
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Alcian blue +, hyaluronidase sensitive
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histo fx of GU-based malignant meso
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epithelioid, biphasic
usually noninvasive/exophytic |
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most common sarcoma of childhood? of adults?
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- embryonal RMS for kids
- liposarcoma for adults |
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5 paratesticular tumors to think about
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-papillary cystadenoma of testis
- adenomatoid tumor - embryonal RMS - liposarcoma - malig mesothelioma |
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what
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pick adenoma, a/w crptorchidism, no spermatogonia
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ihc unique to seminoma of all the GCTs
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cd117
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clinical behavior of spermatocytic seminoma, specific fx to highlight in micro
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-indolent (unless sarcomatoid component)
- polymorphic cells (varying sizes) - spireme (filamentous) nuclei |
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gross of embryonal ca
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often necrotic
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embryonal ca - ihc unique of the GCTs
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CD30
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embryonal ca ihc
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CD30, keratin, OCT3/4 and PLAP
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alt name for yolk sac tumor
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endodermal sinus tumor
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key ihc for yolk sac tumor and two others and histochemical stain (1)
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AFP
keratin, PLAP PAS+ hyaline globules |
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ihc for chorioca
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hcg and keratin
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teratoma in boys
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Immature form: primitive mesenchyme (neurotubules)
b9 course even with immature elements |
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what sertoli cell tumor type is a/w endocrinopathies
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large cell calcifying Sertoli cell tumor
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when are sertoli cell tumors seen bilaterally
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peutz-jeghers
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key ihc for sertoli cell
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inhibin
also keratin |
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what are Charcot-Bottcher filaments
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Spindle-shaped crystalloids seen in sertoli cells by EM
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two syndromes a/w large cell calcifying sertoli cell tumor
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Carneys
Peutz Jegher's |
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some endocrine-related findings in carney's as well as skin fx
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also recall LAMB/NAME
in endocrine, thought to be a ACTH-independent adrenal process Acromegaly Pituitary gigantism Hypercortisolemia Sexual precocity Spotty mucocutaneous hyperpigmentation |
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what
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leydig cell tumor
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what
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leydig cell tumor - reinke's crystals
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ihc for leydig cell tumor
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Inhibin +, keratin +/-
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