High Yield Gyn

Front 1

three causes of PID

Back 1

Neisseria gonorrhoeae
• Chlamydia
• Actinomyces

Front 2

what

Back 2

trich, Frothy discharge
• Fishy odor

Front 3

histo of LSC

Back 3

Squamous hyperplasia associated with inflammation

Front 4

what is BOWENOID PAPULOSIS

Back 4

Multiple small erythematous/white macules/papules
– Both sexes, young
– F: VIN III
– HPV 16, often regress

Front 5

histochemical stains for extramammary paget's

Back 5

Mucin, PAS +

Front 6

what, histo fx, ihc

Back 6

angiomyofibroblastoma:
histo: Well circumscribed
• Alternating hyper and hypocellular zones
• Thin-walled vessels
• Stromal cells, wavy collagen strands
ihc: Vimentin, desmin, CD 34, ER, PR+

Front 7

what, ihc

Back 7

aggressive angiomyxoma: all hypocellular, rbc extravascation, infiltrative border, thin and thick-walled blood vessels
SMA, HHF 35, ER / PR +

Front 8

what

Back 8

mesonephric remnants: mesonephric remnants; stroma is "just around these" CD10+

Front 9

what

Back 9

botryoid rhabdo: note cellular condensation with cambium - less aggressive than other embryonal rhabdo

Front 10

HPV 6, 11 viral protein

Back 10

Koilocytosis related to viral E4

Front 11

viral proteins of HPV16, 18

Back 11

Only early E6, E7 genes expressed
• Integration of viral DNA
• E6 binds P53
• HPV E7 interacts with Rb protein

Front 12

ihc to distinguish endocervical from endometrial ca

Back 12

endocervical adenoca: p16, cea
endometrial: vimentin, CK+, bcl2

random: if mits towards lumen, endocervical (mits usually more basal in endometrium)

Front 13

what is glassy cell carcinoma

Back 13

adenosquamous ca (very aggresive, eos in background)
barrel shaped cx

Front 14

what

Back 14

chlamydia

Front 15

infectious cause of acute endometritis

Back 15

Group A streptococci

Front 16

review dating?

Back 16

dating endometrium
exodus: day 6-10 of endometrium (seen in pap)

Front 17

what is Stein Leventhal syndrome

Back 17

PCOS

Front 18

cytology background endometrial ca

Back 18

watery diathesis?

Front 19

what, uterus

Back 19

apa - note smooth muscle in polyp, usu > 2cm, often squamous morules

Front 20

what

Back 20

adenomatoid tumor

Front 21

endometrial ca with poor prognoses

Back 21

- serous papillary
- clear cell
- scca

Front 22

significance of p53 in endometrial ca

Back 22

associated with more aggressive subtypes

Front 23

ihc for endometrial stroma sarcoma

Back 23

• Beta catenin overexpression
• CD 10 +
• ER / PR +, if low grade ESS
Vimentin +
• Actin – focally +
• Desmin –

Front 24

expected mit count for uterine leiomyosarcoma

Back 24

>10/10hpf

Front 25

tumor arising from endometriosis

Back 25

clear cell
endometrial

hope i have this right

Front 26

what

Back 26

serous tumor; 30-50% bilateral

Front 27

for borderline tumors of ovary, how much invasion is allowed (so not to call invasive)

Back 27

microscopic focus ,3 mm/10mm2 allowed

Front 28

implants from borderline tumors

Back 28

noninvasive: - superficial, stuck on surface
can be desmoplastic but still appear stuck on
invasive: deep, retraction seen

Front 29

name two types of mucinous ovarian tumors and describe clinical implications

Back 29

intestinal type: most are this, if malignant, worse prognosis
mullerian type: more often bl, more often a/w em-osis

Front 30

ck 7 and ck 20 stains for serous and mucinous tumors of peritoneum

Back 30

serous 7+20-
mucin7+20+

Front 31

origin of peritoneal mucinous, serous

Back 31

check this!!!

Front 32

criteria for delineating btwn endometrial ca vs. mixed

Back 32

if >10% of something else, call mixed

Front 33

what, histology

Back 33

clear cell carcinoma: hobnail nuclei, bulge into lumen, Pleomorphic macronucleoli

Front 34

what, ovary

Back 34

granulosa cell tumor

Front 35

ihc for granulosa cell tumor

Back 35

Inhibin
• Calretinin
• Vimentin
• WT1
• CD 99
• S100
• CD56
• SF1 (steroidogenic factor)

Front 36

cytogenetics on granulosa cell tumor

Back 36

FOXL2 gene abnormality on xsome 3

Front 37

what

Back 37

juvenile granulosa cell tumor
very mit active, excellent prognosis
ddx: germ cell, hypercalcemia small cell
histo:
Irregular macrofollicles
• Mitoses common
• Larger, rounded nuclei
• No nuclear grooves
• Abundant leutinized cytoplasm
• Pleomorphism, atypia

Front 38

what, syndrome

Back 38

fibroma, meigs
if fibroma/thecoma: produce estrogen
thecoma component will be oil red O +

Front 39

what

Back 39

sertoli -leydig

Front 40

what

Back 40

sertoli cell tumor

Front 41

what

Back 41

leydig cell tumor, look for reinke's

Front 42

Most common ovarian cancers in
children

Back 42

Germ cell tumors

Front 43

what

Back 43

dysgerminoma

Front 44

what

Back 44

dysgerminoma

Front 45

ihc for dysgerminoma

Back 45

PLAP
– CD117 (membrane staining)
– D2-40
– OCT4
– SALL4
– NANOG
– CK (minimal)
– EMA -

Front 46

what, histo and ihc

Back 46

yolk sac tumor
histo: Lace-like reticular network, Schiller Duvall body
ihc: AFP, Glypican 3, SALL4, CK +

Front 47

what, ihc

Back 47

embryonal ca
Epithelial, glandular
features
• Keratin +, CD 30 +, OCT ¾ +
NANOG, SALL4, SOX2 +

Front 48

what

Back 48

polyembryoma

Front 49

what

Back 49

gliiomatosis peritonei - doesn't come from germ cell itself

Front 50

what

Back 50

immature teratoma

Front 51

what

Back 51

gonadoblastoma

Front 52

what

Back 52

gynadndroblastoma (sertoli and granulosa)

Front 53

carcinosarcoma in ovary vs. endometrium -most common heterolgous component

Back 53

ovary - cartilage
endometrium - rhabdo

Front 54

common tumors to ovary

Back 54

Colon
• Breast
• Stomach
• Pancreas
• Leukemia
• Lymphoma

Front 55

which has better prognosis de novo chorio or postpartum

Back 55

postpartum
(ovarian chorioca has worst prognosis)