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52 Cards in this Set
- Front
- Back
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Which Hepatitis Virus is DNA?
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B-Double stranded DNA
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Which hepatitis virus contain and Envelope?
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B,C,D
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How many genotypes does Hepatitis C have and which is the least responsive to therapy?
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6 genotypes
1 & 4 are the least responsive to therapy |
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What other Hepatitis must be present for D to invade?
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B
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In the US, where is Hep A most prevalent?
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West coast
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What Hep do you see in daycare centers?
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A
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What is the first indicator of Hep A infection?
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ALT increased and Hep A found in fecal matter
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What is the Hep A vaccine called?
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HAVRIX and VAQTA
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What in the Twinrix vaccination?
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Combines Hep A and B
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What is the classification of Hep B virus?
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Hepadenaviridae
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The most common KNOWN risk factor for contracting Hep B is?
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IV drug users and Homosexuality
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What is fulminant?
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When a person has hepatitis that has progressed into encephalopathy and liver failure
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Which Hep are you at risk for Hepatocellular Carcinoma?
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B,C
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HBsAG
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Acute/chronic
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Anti-HBc IgM
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Acute
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HBeAg
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High Infectivity
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Anti-HBe
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Low infectivity
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Anti HBs
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Immunity
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Anti-HBc IgC and HgsAg
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Chronic Infection
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Anti HBc IgC and anti-HBs
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resolved
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HBe and HBV DNA
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Chronic infection
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What are the 3 criteria to classify Hep as chronic?
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HBsAG for longer than 6 months
ALT high HBV DNA positive >10^5 |
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HBsAg > 6mnths
HBeAg - HBeAB + HBV DNA < 10^5 |
Inactive carrier state
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HBsAg -
HBsAB + HBcAB + |
complete Recovery
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When is treatment indicated in Hepatitis B infection?
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HBsAg> 6mnths
HBV DNA > 10^5 copies ALT greater than 2x normal |
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What are the treatments for Hepatitis?
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Interferon,
Nucleotide analogues La.miv.u.dine A.def.o.vir (a.dif.o.ver) Entecavir Famciclovir |
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What do you give HBeAg + patients?
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Alpha interferon
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What is interferon therapy contraindicated?
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In decompensated cirrhosis bc of risk of sepsis
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Which Hep therapy shows resistance?
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lamivudine
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Which Hep therapy's can be taken orally?
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lamivudine and adefovir
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What is a disadvantage of Interferon treatment?
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Lot's of side effects
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Does Adefovir show any resistance?
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NO
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In the united states which population is the most infected with Hep C
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African American
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The high risk population for Hep C is?
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IV drug users and
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HCV Ab test?
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Indicates past or present infection
Poor Positive predictor value inexpensive |
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What test confirms a Hep C infection?
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Qualitative HCV RNA (PCR)
Proves an active infection |
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What is the Gold standard for diagnosing Hep C?
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Quantitative HCV RNA
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What genotype of Hep C do most people in the U.S.
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Type 1- difficult to treat
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EVR
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Early Virological Response
-Drop in HCV RNA by atleast 2 log of 10 with 12 weeks of therapy |
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ETR
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End of Treatment Response
-HCV RNA is < 50IU/ml at the end of treatment |
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SVR
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Sustained Virological Response
-HCV RNA is < 50IU/ml after 6 mnths of treatment |
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What is relapse?
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means the during treatment HCV DNA and ALT levels dropped but soon after you stop treatment levels rise back up to pretreatment values
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Non-responder to treatment?
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ALT decrease a little but not significant and the HCV DNA decrease at first but then go back up even though their on treatment
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What is the treatment for Hep C?
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Interferon and ribavirin RIb.A.vair.in
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What is one of the major side effects of ribavirin?
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Hemolytic Anemia
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What are the Hematological disorders associated with Hep C?
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Non-hodgkin's Lymphoma
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What are the renal disorder associated with Hep C?
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membranous nephropathy
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What are the Dermatological disorders associated with Hep C?
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Porphyria Cutanea Tarda
Lichen Planus |
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What are the Autoimmune disorders associated with Hep C?
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Idiopathic thrombocytopenia purpura
Diabetes mellitus |
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Cryoglobulinemia
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is the presence of high amount of heavy globulins (e.g. IgM) in the bloodstream which thicken or gel on exposure to cold. Such proteins are called cryoglobulins.
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Which type of cryoglobulinemia have Hep C 100% of the time?
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II
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What Hep has a 20% mortality rate among women in their 3rd trimester?
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Hep E
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