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25 Cards in this Set
- Front
- Back
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mechanism of heparin-like molecules?
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enhance antithrombin III activity and neutralize activated serine protease coagulation factors (XII, XI, IX, X)
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prostaglandin function?
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synthesized by intact endothelial cells; vasodilator; inhibits platelet aggregation
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proteins C and S function?
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vitamin K-dependent; inactivate factors V, VIII; enhance fibrinolysis
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tissue plasminogen activator?
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synthesized by endothelial cells; activates plasminogen to release plamin that degrades coagulation factors and lyses fibrin clots
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aspirin mechanism?
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irreversibly inhibits platelet cyclooxygenase
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TXA2 functions?
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vasoconstrictor, enhances platelet aggregation
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Weibel-Palade bodies in endothelial cells?
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where vWF is synthesized
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vWF complexes with?
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factor VIII preventing degradation
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platelet receptors?
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GpIb: for vWF
GpIIb-IIIa: for fibrinogen |
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petechiae pathogenesis?
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platelet dysfunction causes leakage of rbcs
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extrinsic system?
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factor VII --> VIIa --> activate X in final common pathway
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intrinsic system?
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factors XII, XI, IX, VIII
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final common pathway?
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factors X, V, prothrombin (II), fibrinogen (I)
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vitamin K dependent factors?
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II, VII, IX, X, protein C, protein S
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coagulation factors consumed in formation of fibrin clot?
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fibrinogen (I), factor V, factor VIII, prothrombin (II)
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at what level of thrombocytopenia does increased bleeding time occur?
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<90,000
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how does renal failure cause prolonged bleeding time?
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inhibition of platelet phospholipid by toxic products that is reversed with dialysis and desmopressin acetate
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what does bleeding time evaluate?
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platelet function up to formation of the temporary platelet plug
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tests for vWF?
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ristocetin: evaluate vWF function (abnormal in vWD, bernard-soulier disease);
vWF antigen assay: measures quantity of vWF |
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prothrombin time?
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extrinsic system (VII, X, V, II, I)
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INR?
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international normalized ratio for PT; for use in warfarin therapy
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uses of PT?
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follow warfarin therapy, evaluate liver synthetic function, VII deficiency
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PTT?
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intrinsic system (XII, XI, IX, VIII, X, V, II, I)
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uses of PTT?
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follow heparin therapy, detect deficiencies
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causes of DIC?
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sepsis, disseminated malignancy, crush injuries, rattlesnake envenomation, amniotic fluid embolism, abruptio placentae
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