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45 Cards in this Set
- Front
- Back
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fluid portion of blood, extracellular
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plasma
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increases osmotic pressure of the blood, preventing the plasma from leaking into tissue
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albumin
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globulins
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transport other substances and protect the body from infection
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What is the main component of antibodies
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globulins
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A protein molecule that can be activated to form fibrin
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fibrinogen
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What three elements to plasma contain
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albumin, globulins, fibrinogen
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What are the cellular portions of blood
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RBC and WWBC
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Where is the site of hematopoiesis?
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bone marrow - stem cells, imature undifferentiated cells are produced in bone marrow
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Give an example of how stem cells and their development...
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RBC= stem cell from bone marrow interacts with specific growth factors like erythropoiten in kidneys
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Describe RBCs
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-highest proportion of blood
-concave shape -flexible |
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What is lifespan of RBC?
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120 days
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What is the normal range of RBC?
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4.2-6.1
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What is needed for oxygen transportation?
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Iron is required for HGB to attach and transport O2
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What is erythropoetin?
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controls the production of RBC through the level of o2 tissue saturation
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what is oxygen dissassociation?
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spped and amount of O2 to tissue
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what triggers erythropoiesis?
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low O2, ypoxia, decreassed B/P
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what is a synthetic form of erythropoietin?
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epogen
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What elements are required to make RBC?
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Iron, folic acid, B12, and protein
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immune system cells that protect the body from invation...
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white blood cells
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what is another name for WBC
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leukocytes
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What function do WBC have?
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-recognize self vs. nonself
-destruction of invaders -destruction of unhealthy cells -production of antibodies |
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three process for immunity?
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inflammation, antibody mediated immunity, cell mediated immunity
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What is a left shift?
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When the body demands increased WBC, but the demand is too high and many immature band cells
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What are band cells
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baby, less mature neutrophils/granuloctyes
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What is the reticulocyte count?
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5-10
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What are Eosinophils?
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act against infestation, like parasitic larvae
-can induce inflammation |
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What is normal range of Eosinophils?
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1-4; this increases in an allergic reaction
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What do basophils do?
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cells that manifest inflammation, released on allergy
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What do Basophils contain?
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heparin, histamine, and kinins
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What inhibits blood and protein clotting?
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heparin
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histamine
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constrics small veins and respiratory muscles
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kinins
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dilate arterioles and increase capillary permeability
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what is the body's first line of defense?
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neutrophils
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What do neutrophils do?
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first to arrive on the scene of infection
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What are monocytes?
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second to arrive on the scene to continue help; accumulate in fluid (lymphs); provide immediate and long immune response
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What do lymphocytes do?
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produce substances that attack foreign material
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What do T cells do?
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attack infected cells, release lymphokines to assist with phagocytosis
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What do B cells do?
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produce antibodies;
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What are thrombocytes?
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platelets, with life span of 7-10 days; stick to injured sites form platelet plugs to stop bleeding
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What is range of platelets?
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150-400,000
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what do platelets do?
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-control bleeding
-form platelet plugs at site of injury -intitate formation of fibrin clot |
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What does intrinsic mean for a blood clot?
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-pathway is slower,
-problem is changes inside the blood -use of HEPRIN |
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What does extrinsic mean for a blood clot?
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-pathway is faster
-problem is changes in the blood vessel (outside bld) -use of Coumadin |
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What labs do you review for Heprin?
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PTT 1.5-2.5
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What labs do you review for Coumadin?
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PTINR 2-3.5
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