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34 Cards in this Set

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tear drop RBC
tumor
DIC
MAHA
schistocyte
MAHA
TTP
HUS
elliptocyte
usually congential (mild)
sometimes iron deficiency anemia
target cells
large - liver disease
small - thalassemia
acanthocyte
end stage liver disease
cholesterol metabolism disorders
dislipoproteinemias
microcytes
fe deficiency
thalassemia
macrocytes
sometimes these are oval macrocytes...

b12/folate def.
liver disease (??)
rouleaux formation
increased paraprotein (multiple myeloma)
agglutination
cryoglobulinemia or cold agglutinins
basophilic stippling
"young" RBCs that still contain a lot of RNA

seen in hemolytic anemias, whenever the bone marrow is revved up
howell-jolly bodies
asplenia (or nonfunctional spleen)

hj bodies are persistent nuclear bodies, the spleen normally takes care of that
cabot rings
mitotic spindle abnormalities
pappenheimer bodies
aka hemosiderin bodies

these are iron particles

-sideroblastic anemia
-hemolytic anemia

xs iron in bone marrow
polychromatophilic disease
pale, earlier RBC's
more RNA (bluer)
less Hgb (less pink)
===> slate color

often seen with NRBCs

marrow recovery (from chemo, etc)
hemolytic anemia
metastatic tumor in BM
leukopenia
less than 1500 leukocytes / ul
leukocytosis
more than 15,000 leukocytes / ul

(transient - indicates infection)
NRBC
often seen with polychromatophilic RBCs

marrow recovery (from chemo, etc)
hemolytic anemia
metastatic tumor in BM
neutropenia
less than 1000 PMNs / ul
leukemoid reaction
more than 30,000 leukocytes / ul

transient
toxic granules
excess granules in PMN
seen:
-infections
-post chemotherapy

seen when neutrophils are being released more quickly and contain more early enzyme packets than normal
dohle body
Döhle bodies are light blue-gray inclusions in neutrophils.

They are seen in:

Burns
Infections
Physical trauma
Neoplastic diseases
Wissler’s disease
May-Hegglin’s anomaly
Chédiak-Steinbrinck-Higashi’s syndrome
hypersegmented neutrophils
macrocytosis
mild leukopenia
-severe renal disease (uremia)
-b12/folate deficiency
-most liver diseases

(not sure why??)
hyposegmented and hypogranular neutrophils with early myeloid and monocytoid cells
-myelodysplastic syndrome (preleukemic state)
-recovering marrow
leukocytosis
basophilia
early myeloid forms
* CML = chronic myelogenous leukemia (myeloproliferative syndrome)
- leukemoid reaction
butterfly nucleus
=promyelocytes with pink granules and butterfly nucleus

ddx:
-acute promyelocytic leukemia
-recovering marrow
auer rods
auer rods - always think myeloid leukemia
leukocytosis with early forms (monoblasts)
near transparent nucleus and folds
cytoplasmic vacuoles
-chronic myelomonocytic leukemia
-promyelocytic leukemia (hypogranular)
lymphocytosis with atypical lymphocytes
plasmacytoid cells
these are ACTIVATED lymphocytes (reactive, not neoplastic)

-viral infection (EBV, hiv, cmv, anything)
-medication
-ALWAYS R/O lymphoma / leukemia!
small imperceptible cytoplasm
these are immature lymphoid cells (lymphoblasts)
they form clusters/aggregates

-acute lymphoid leukemia (Precursor B or T cell type)
leukopenia
large granular lymphoid cells
neutropenia
anemia
-large granular lymphoid leukemia
clear cytoplasm
shaggy cytoplasm
reticulated nucleus
larger lymphoid cells
-hairy cell leukemia
-primary splenic leukemia (WTF?)
lymphocytosis
smudge cells
chromatin condensation
-chronic lymphocytic leukemia
-lymphocytosis
high platelet count
large agranular platelets
abnormal shape
-essential thrombocythemia
-reactive thrombocytosis
-myeloproliferative syndromes
platelet satellitism and clumping
seen when there is endothelial cell activation - ex venopuncture