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34 Cards in this Set
- Front
- Back
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tear drop RBC
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tumor
DIC MAHA |
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schistocyte
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MAHA
TTP HUS |
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elliptocyte
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usually congential (mild)
sometimes iron deficiency anemia |
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target cells
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large - liver disease
small - thalassemia |
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acanthocyte
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end stage liver disease
cholesterol metabolism disorders dislipoproteinemias |
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microcytes
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fe deficiency
thalassemia |
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macrocytes
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sometimes these are oval macrocytes...
b12/folate def. liver disease (??) |
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rouleaux formation
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increased paraprotein (multiple myeloma)
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agglutination
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cryoglobulinemia or cold agglutinins
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basophilic stippling
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"young" RBCs that still contain a lot of RNA
seen in hemolytic anemias, whenever the bone marrow is revved up |
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howell-jolly bodies
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asplenia (or nonfunctional spleen)
hj bodies are persistent nuclear bodies, the spleen normally takes care of that |
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cabot rings
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mitotic spindle abnormalities
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pappenheimer bodies
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aka hemosiderin bodies
these are iron particles -sideroblastic anemia -hemolytic anemia xs iron in bone marrow |
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polychromatophilic disease
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pale, earlier RBC's
more RNA (bluer) less Hgb (less pink) ===> slate color often seen with NRBCs marrow recovery (from chemo, etc) hemolytic anemia metastatic tumor in BM |
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leukopenia
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less than 1500 leukocytes / ul
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leukocytosis
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more than 15,000 leukocytes / ul
(transient - indicates infection) |
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NRBC
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often seen with polychromatophilic RBCs
marrow recovery (from chemo, etc) hemolytic anemia metastatic tumor in BM |
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neutropenia
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less than 1000 PMNs / ul
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leukemoid reaction
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more than 30,000 leukocytes / ul
transient |
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toxic granules
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excess granules in PMN
seen: -infections -post chemotherapy seen when neutrophils are being released more quickly and contain more early enzyme packets than normal |
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dohle body
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Döhle bodies are light blue-gray inclusions in neutrophils.
They are seen in: Burns Infections Physical trauma Neoplastic diseases Wissler’s disease May-Hegglin’s anomaly Chédiak-Steinbrinck-Higashi’s syndrome |
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hypersegmented neutrophils
macrocytosis mild leukopenia |
-severe renal disease (uremia)
-b12/folate deficiency -most liver diseases (not sure why??) |
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hyposegmented and hypogranular neutrophils with early myeloid and monocytoid cells
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-myelodysplastic syndrome (preleukemic state)
-recovering marrow |
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leukocytosis
basophilia early myeloid forms |
* CML = chronic myelogenous leukemia (myeloproliferative syndrome)
- leukemoid reaction |
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butterfly nucleus
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=promyelocytes with pink granules and butterfly nucleus
ddx: -acute promyelocytic leukemia -recovering marrow |
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auer rods
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auer rods - always think myeloid leukemia
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leukocytosis with early forms (monoblasts)
near transparent nucleus and folds cytoplasmic vacuoles |
-chronic myelomonocytic leukemia
-promyelocytic leukemia (hypogranular) |
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lymphocytosis with atypical lymphocytes
plasmacytoid cells |
these are ACTIVATED lymphocytes (reactive, not neoplastic)
-viral infection (EBV, hiv, cmv, anything) -medication -ALWAYS R/O lymphoma / leukemia! |
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small imperceptible cytoplasm
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these are immature lymphoid cells (lymphoblasts)
they form clusters/aggregates -acute lymphoid leukemia (Precursor B or T cell type) |
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leukopenia
large granular lymphoid cells neutropenia anemia |
-large granular lymphoid leukemia
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clear cytoplasm
shaggy cytoplasm reticulated nucleus larger lymphoid cells |
-hairy cell leukemia
-primary splenic leukemia (WTF?) |
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lymphocytosis
smudge cells chromatin condensation |
-chronic lymphocytic leukemia
-lymphocytosis |
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high platelet count
large agranular platelets abnormal shape |
-essential thrombocythemia
-reactive thrombocytosis -myeloproliferative syndromes |
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platelet satellitism and clumping
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seen when there is endothelial cell activation - ex venopuncture
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