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3 Cards in this Set
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Plasmablastic lymphoma
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Uncommon. Highest in HIV-infected individuals, m>f. Also other immunodeficiency states.
EBV-infected in majority. Presents oral cavity>mucosal sites (orbit, sinonasal), skin, bone ,soft tissue, GI tract. Nodal involvement uncommon. Transformation of MM to PBL occurs (prior history of MM). Looks immunoblastic (oral, head/neck) to plasmacytic (more in other sites, LNs) CD138, 38+, CD45, 20, pax5-. CD79a+ in 50-85%. If CD56+ think underlying plasma cell myeloma. Ki67 usually >95%. EBER+ in 60-75%. HHV8 negative. Prognosis bad, most die <1yr. HIV management? |
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Plasma cell myeloma
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Extraosseous plasmacytoma
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