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7 Cards in this Set
- Front
- Back
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Polycythemia vera critaria |
Major critaria Clinical - Hb M >16.5 F>16 Hct Hbx3 M> 49 F>48 Morphological - Bone marrow - hypercellularity with trilineage growth - panmyelosis Genetic critaria - mutation JAK2V617F JAK2 exon 12 Minor critaria Erythropoietin normal or less if increased secondary polycythemia not genetic |
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Clinical feature of polycythemia vera |
RBC - Red plethoric face HTN Dizziness WBC - Aquagenic pruritus - itching after hot water bath. Lots of mast cells Platelet - Erythromelalgia |
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Polycythemia vera mutation |
JAK2V617F |
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Small sized platelet is seen in which disease |
Wiscott Aldrich syndrome Repeated episodes of bleeding |
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Large sized platelets are associated with which ds |
Bernard Soulier syndrome ITP |
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Rosai Dorfman disease Sinus histiocytosis with massive lymphadenopathy Emperipolesis Bilateral massive cervical lymph nodes Gradually increasing in size Multiples nodules in arms |
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Emperipolesis is seen in |
Cell within cell appearance Cells are engulfed but not killed MARC MDS Autoimmune hepatitis Rosai Dorfman ds CLL |
