Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
46 Cards in this Set
- Front
- Back
|
Hodgkin's or non-Hodgkin's: Reed-Sternberg cells
|
Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: Localized, single group of nodes, extranodal rare, contiguous spread
|
Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: low grade fever, night sweats, weight loss
|
Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: mediastinal lymphadenopathy
|
Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: 50% associated with EBV
|
Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: bimodal distribution, M>F except for which subtype?
|
Hodgkin's; nodular sclerosing
|
|
|
What is typically indicates a good prognosis for Hodgkin's lymphoma?
|
Increased lymphocytes, decreased Reed-Sternberg cells
|
|
|
Hodgkin's or non-Hodgkin's: associated with HIV and immunosuppresion
|
Non-Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: associated with multiple, peripheral nodes; extranodal involvment common, noncontiguous spread
|
Non-Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: no hypergammaglobinemia
|
Non-Hodgkin's lymphoma
|
|
|
Hodgkin's or non-Hodgkin's: peak incident 20-40 yo
|
Non-Hodgkin's lymphoma
|
|
|
List the Hodgkin's lympomas
|
Nodular sclerosing, mixed cellularity, lymphocyte predominant, lymphocyte depleted
|
|
|
Which of these Hodgkin's lymphomas have excellent, intermediate, and poor prognosis: mixed cellularity, lymphocyte depleted, nodular sclerosing, lymphocyte predominant
|
Excellent: nodular sclerosing and lymphocyte predominant; Intermediate: mixed cellularity; Poor: lymphocyte depleted
|
|
|
Hodgkin's lymphoma: RS +; Lymphocytes +++; collagen banding, lacunar cells, F>M, primarily young adults
|
Nodular sclerosing
|
|
|
Hodgkin's lymphoma: RS ++++; Lymphocytes: +++; numerous RS cells
|
Mixed cellularity
|
|
|
Hodgkin's lymphoma: RS +; Lymphocytes ++++; < 35 yo males
|
Lymphocyte predominant
|
|
|
Hodgkin's lymphoma: RS high relative to lymphocytes; Lymphocytes +; older males, disseminated disease
|
Lymphocyte depleted
|
|
|
Disease: hypercalcemia, renal insufficiency, infections, anemia, primary amyloidosis, monoclonal Ig spike, Bence Jones proteins, Rouleaux formation
|
Multiple myeloma
|
|
|
Disease: M spike, hyperviscosity symptoms, but not lytic bone lesions
|
Waldenstrom's macroglobulinemia
|
|
|
What cell is the cause of mutiple myeloma?
|
Monoclonal plasma cell --> produce IgG (55%) or IgA (25%)
|
|
|
If multiple myeloma is asymptomatic, then it is called
|
Monoclonal gammopathy of undetermined significance (MGUS)
|
|
|
List the non-Hodgkin's lymphomas
|
Small lymphocytic lymphoma, follicular lymphoma (small cleaved cell), diffuse large cell lymphoma, mantle cell lymphoma, lymphoblastic lymphoma, Burkitt's lymphoma
|
|
|
Children get which non-Hodgkin's lymphomas?
|
Lymphoblastic lymphoma, burkitt's lymphoma, 20% diffuse large B cell are in children
|
|
|
Adults get which Hodgkin's lymphomas?
|
Small lymphocytic lymphoma, follicular lymphoma, 80% diffuse large B cell are in adults, mantle cell lymphoma
|
|
|
Which non-Hodgkin lymphomas involve B cells?
|
Small lymphocytic lymphoma, follicular lymphoma, diffuse large cell lymphoma (80%), mantle cell lymphoma, Burkitt's lymphoma
|
|
|
Which Hodgkin lymphomas involve T cells?
|
Diffuse large cell lymphoma (20%), lymphoblastic lymphoma (immature T cells)
|
|
|
What is the most common non-Hodgkin's lymphoma in adults?
|
Follicular lymphoma
|
|
|
Which non-Hodgkin lymphoma has a starry-sky appearance and is associated with EBV?
|
Burkitt's lymphoma
|
|
|
In Africa, Burkitt's lymphoma affects the ______________; in Western countries, Burkitt's lymphoma affects the _____________.
|
Jaw; Pelvis or abdomen
|
|
|
What is the translocation of chronic myelogenous leukemia?
|
t(9;22) Philadelphia chromosome - bcr-abl hybrid
|
|
|
What is the translocation of Burkitt's lymphoma?
|
t(8;14) c-myc activation
|
|
|
What is the translocation of follicular lymphoma?
|
t(14;18) bcl-2 activation
|
|
|
What is the translocation of M3 type of AML?
|
t(15;17) responds to all-trans retinoic acid
|
|
|
What is the translocation of Ewing's sarcoma?
|
t(11;22)
|
|
|
What is the translocation of mantle cell lymphoma?
|
t(11;14)
|
|
|
Leukemia: < 15 yo
|
Acute lymphocytic leukemia
|
|
|
Leukemia: < 5-40 yo
|
Acute myelocytic leukemia
|
|
|
Leukemia: 30-60 yo
|
Chronic myeloid leukemia
|
|
|
Leukemia: > 60 yo
|
Chronic lymphocytic leukemia
|
|
|
Leukemia: lymphoblasts, TdT+ (pre-T and pre-B cell marker), can spread to CNS and testes, most responsive to therapy
|
Acute lymphocytic leukemia
|
|
|
Leukemia: Auer rods, myeloblasts
|
Acute myelogenous leukemia
|
|
|
Leukemia: lymphadenopathy, hepatosplenomegaly, but generally few symptoms, smudge cells on blood smear, warm Ab autoimmune hemolytic annemia
|
Chronic lymphocytic leukemia
|
|
|
Leukemia: myeloid stem cell proliferation, increased neutrophils and metamyelocytes, splenomegaly, very low alkaline phosphatase
|
Chronic myeloid leukemia
|
|
|
Leukemia: elderly, filmaentous hair-like projections on cells, stains TRAP
|
Hairy cell leukemia
|
|
|
Disease: Birbeck granules (tennis rackets on EM), young adults, worse with smoking
|
Histiocytosis X
|
|
|
What is the etiology of histocytosis X?
|
Langerhans cells from monocyte lineage infiltrate the lung
|
