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12 Cards in this Set
- Front
- Back
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Common stem cells express which surface protein?
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CD34
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CD34+ cells differentiate into what?
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myeloid and lymphoid blasts
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Mutations in stem cells lead to what?
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myeloproliferative disease
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Mutations in blast cells lead to what?
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acute leukemias
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Myeloblasts differentiate into the progenitors of...?
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1) RBC
2) megakaryocyte 3) mast cell 4) monocyte 5) granulocyte (neu, eos, bas) |
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Lymphoid blasts mature into what?
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1) T-cells
2) B-cells 3) NK cells |
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How long do Platelets circulate?
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7 days
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You have increased risk of infection if neutrophil count drops below _____.
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< 1000/mL
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What is myelodysplasia?
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1) Pre-leukemic
2) Increased # abnormal myeloid blasts in marrow (if see blasts in peripheral blood then suggest acute leukemia) |
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What is the difference between "lymphocyte leukemia" and "lymphoma?"
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Lymphocytic leukemia = cells in blood
Lymphoma = cell are parenchymal |
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How long after chemo/radiation therapy can you anticipate acute leukemia?
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5-10 years later
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Cellularity of bone marrow = _____ - _____
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100 - patient's age
*minimum 20% cellularity |
