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5 Cards in this Set
- Front
- Back
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Digoxin effects |
Mechanical- 1.dec pre and afterload 2. Renal perfusion 3. Dec tone 4. Dec work load Electrical- 1. Inc PR dec QT and Dec ST invert T 2. Inc automaticity all 3. Dec AV conduction 4. IncAV refractory |
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Digoxin clinical |
Heart- 1. CHD 2. Atrial flutter and fibrillation 3. Atrial nodal arrythmia Git- anorexia, nausea, vomit Cns-depression, convulsion, irritation, disorientation(old) Eyes- color perception Visual disturbance Gynaecomastia |
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Digitalis electrolyte changes |
These condition are toxic Hypokalemia- compete at binding to Na K atpase Hypomagnesemia vomiting Hypercalcemia- more cal inside available
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Digoxin interractions |
1.Quinidine- displace binding site 2.Cholestyramine- dec BA 3.Clarithromycin- inc BA 4. NSAID- like quinidine 5.Hyperthyroidism - inc metabolism 6. Ca blockers 7. Sympathomimetics' inc arrythmia
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Digoxin treat toxicity |
1. Acute- hyperkalemia If already k sparing given, then not. 2. Lidocaine then given or phenytoin 3. If not treated- fab anibodies from sheep |
