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27 Cards in this Set

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What is the dif b/w hirsutism and virilization?
hirustism: male-pattern hair growth in female
viril: male-pattern BALDing, inc musc mass, deepen voice, clitoromegaly, male body habitus
what hormone cz hirustism, viril?
inc androgens
Name some cz of inc androgens
PCOS
congenital adrenal hyperplasia
adrenal neoplasm
meds
Cushing syndrome
Sertoli-Leydig cell ovarian tumors
luteoma of preg
Defin PCOS: polycystic ovarian syndrome
oligomenorrhea w/ signs and symptoms of inc circulating androgens
T or F
PCOS is char by
1. chronic anovulation
2. b/l polycystic ovaries
3. infertility
T
PCOS affects what age
15-30
PCOS affects what body habitus?
a. obese and hirsute
b. skinny and hairless
obese and hirsute
what is the cz of PCOS
unknown
what causes the symptoms
excess LH, androgen overprod
what endocrine dz is assoc?
dm, insulin resistance
what ca risk is inc, due to unopposed estrogen?
endometrial ca
most common complaints of PCOS*
1. hirsutism
2. amenorrhea
3. infertility
what other char may be found with pt
OBESITY
virilization
acne
dm
htn
acanthosis nigricans
desc ovaries that may be found on bimanual exam
enlarged cystic ovaries
what is the LH/FSH ratio
>3
what other hormones are inc
serum androstenedione, DHEA
what does u/s show of ovaries
enlarged w/ many subcapsular cysts
what is used to tx the hirsutism, amenorrhea, acne?
OCP
what TLC helps with insulin resistance
wgt reduct
what 2 used to tx infertility
clomiphene citrate
metformin
acanthosis nigricans is diffuse hyperpigmentation assoc with what dz?
hereditary
endocrine d/o
obesity
malig
drugs (5FU, amiodarone, bleomycin, chlorpromazine, chloroquine, daunorubicin, gold, minocycline)
acanthosis nigricans appear as dirty-appear, velvety plaques found predom where?
axilla, neck
congenital adrenal hyperplasia commonly results in defic of cortisol, most commonly assoc w/ which enz?
auto-recess defect in 21-hyroxylase
121
sev 21-hydroxylase defic results in mineralocorticoid defic (aldosterone), leading to salt wasting--req minerlocorticoid replacement --example.
fludricortisone
Desc genitalia in F and M of CAH.
F: ambiguous genitilia
M: macrogenitosomia
T or F
virilization occurs later in life
T
medical tx for CAH
admin cortisol to reduce ACTH and adrenal androgens