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27 Cards in this Set
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What is the dif b/w hirsutism and virilization?
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hirustism: male-pattern hair growth in female
viril: male-pattern BALDing, inc musc mass, deepen voice, clitoromegaly, male body habitus |
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what hormone cz hirustism, viril?
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inc androgens
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Name some cz of inc androgens
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PCOS
congenital adrenal hyperplasia adrenal neoplasm meds Cushing syndrome Sertoli-Leydig cell ovarian tumors luteoma of preg |
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Defin PCOS: polycystic ovarian syndrome
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oligomenorrhea w/ signs and symptoms of inc circulating androgens
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T or F
PCOS is char by 1. chronic anovulation 2. b/l polycystic ovaries 3. infertility |
T
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PCOS affects what age
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15-30
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PCOS affects what body habitus?
a. obese and hirsute b. skinny and hairless |
obese and hirsute
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what is the cz of PCOS
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unknown
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what causes the symptoms
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excess LH, androgen overprod
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what endocrine dz is assoc?
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dm, insulin resistance
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what ca risk is inc, due to unopposed estrogen?
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endometrial ca
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most common complaints of PCOS*
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1. hirsutism
2. amenorrhea 3. infertility |
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what other char may be found with pt
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OBESITY
virilization acne dm htn acanthosis nigricans |
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desc ovaries that may be found on bimanual exam
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enlarged cystic ovaries
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what is the LH/FSH ratio
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>3
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what other hormones are inc
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serum androstenedione, DHEA
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what does u/s show of ovaries
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enlarged w/ many subcapsular cysts
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what is used to tx the hirsutism, amenorrhea, acne?
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OCP
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what TLC helps with insulin resistance
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wgt reduct
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what 2 used to tx infertility
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clomiphene citrate
metformin |
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acanthosis nigricans is diffuse hyperpigmentation assoc with what dz?
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hereditary
endocrine d/o obesity malig drugs (5FU, amiodarone, bleomycin, chlorpromazine, chloroquine, daunorubicin, gold, minocycline) |
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acanthosis nigricans appear as dirty-appear, velvety plaques found predom where?
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axilla, neck
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congenital adrenal hyperplasia commonly results in defic of cortisol, most commonly assoc w/ which enz?
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auto-recess defect in 21-hyroxylase
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121
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sev 21-hydroxylase defic results in mineralocorticoid defic (aldosterone), leading to salt wasting--req minerlocorticoid replacement --example.
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fludricortisone
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Desc genitalia in F and M of CAH.
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F: ambiguous genitilia
M: macrogenitosomia |
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T or F
virilization occurs later in life |
T
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medical tx for CAH
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admin cortisol to reduce ACTH and adrenal androgens
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