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11 Cards in this Set
- Front
- Back
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Cytokines that stimulate the activation of integrins on PMNs?
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C5a
LTB4 |
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Cytokines that stimulate the activation of ICAM/VCAM on endothelial cells?
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IL-1
TNF |
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Cytokines that are chemotactic for PMNs?
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C5a
LTB4 IL-8 |
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Stimulates angiogenesis
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VEGF
BFGF |
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Functions of Epidermal Growth Factor (EGF)?
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Keratinocyte migration
Stimulates granulation tissue formation |
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Functions of PDGF?
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Proliferation of smooth muscle, fibroblasts, and endothelial cells
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Functions of TGF-beta?
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Chemotactic for macrophages, lymphocytes, fibroblasts
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Cell adhesion glycoprotein in ECM that is a chemotatic factor for fibroblasts and required for granulation tissue formation?
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Fibronectin
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Function of IGF-1 in tissue repair?
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Stimulates the synthesis of collagen
Promotes keratinocyte migration |
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Function of IL-1 in tissue repair?
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1. Chemotactic for PMNs
2. Stimulates synthesis of metalloproteinases 3. Stimulates synthesis and release of acute phase reactants from liver |
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Restoration of damaged tissue to normal requires preservation of the basement membrane. What is the key BM adhesion protein that interacts w/ components in the ECM (collagen, cell surface receptors)?
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Laminin
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