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18 Cards in this Set
- Front
- Back
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primary leukocytes in acute inflammation
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PMNs
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selectins
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responsible for "rolling" of PMNs
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delayed separation of umbilical cord
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selectin or CD11a:CD18 def
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can't form phagolysosomes in
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Chediak Higashi
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MPO def
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normal respiratory burst
NADPH oxidase converts molecular O2 to superoxide anion, which releases energy called respiratory burst |
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leukocytes of chronic inflammation
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macs and monocytes
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G1 phase
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synthesis of RNA, protein, organelles, and cyclin D
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G2
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synthesis of tubulin which is needed for the mitotic spindle
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S phase
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synthesis of DNA, RNA, and protein
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RB
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RB protein product arrests the cell in the G1 phase
Cdk4 phosphorylates the Rb protein causing the cell to move into S phase |
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stages of cell cycle
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G1 --> S --> G2 --> M
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p53
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arrests cell in the G1 phase by inhibiting Cdk4
this prevents phosphorylation of Rb |
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Ehler-Danlos
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defects in type I and III collagen due to lysyl oxidase def
hypermobile joints, aortic dissection, bleeding into skin, and poor wound healing |
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keloids
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excess type III collagen
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type II pneumocytes
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repair cells
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peripheral nerve resection
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schwann cell is key cell in reinnervation
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can cause increased ESR
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increased fibrinogen and anemia
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C-reactive protein
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increased in inflammatory (disrupted) atherosclerotic plaques and bacterial infections
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