Goljan Hepatobiliary And Pancreatic Disorders

Front 1

urobilin

Back 1

color of stool and urine

Front 2

most common cause of jaundice

Back 2

hepatitis

Front 3

second most common cause of jaundice

Back 3

Gilbert's

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HepA

Back 4

most common cause of hepatitis and jaundice

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HBsAg > 6 months

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defines chronic HBV

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only marker present in window phase

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anti-HBc-IgM

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Anti-HbS

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protective Ab
immunization or recovery from past infection

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extravascular hemolysis: urine UBG and urine bilirubin

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UBG +++
urine bilirubin 0

Front 9

cholestatis: urine UBG and urine bilirubin

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UBG 0
urine bilirubin ++

Front 10

viral hepatitis: urine UBG and urine bilirubin

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UBG ++
urine bilirubin ++

Front 11

AI hepatitis

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positive serum ANA and anti-smooth muscle antibodies

Front 12

neonatal hepatitis

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multifactorial
biopsy shows multinucleated giant cells

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Reyes syndrome

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enceophalopathy
fatty change in liver

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fulminant hepatic failure

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decreased transaminases
increased PT and ammonia

Front 15

hepatic artery infarction

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uncommon

Front 16

portal vein thrombosis

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ascites
portal HTN
no hepatomegaly

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intrahepatic obstruction to blood flow

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cirrhosis is most common cause

Front 18

centrilobular necrosis

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combined LHF and RHF
"nutmeg" liver

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most common cause of hepatic vein thrombosis

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polycythemia vera

Front 20

alcoholic hepatitis

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acetaldehyde damages hepatocytes

Front 21

extrahepatic cholestasis

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most often due to a stone in the common bile duct

Front 22

primary sclerosing cholangitis

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strong ass. with UC
obliterative fibrosis of intrahepatic and extrahepatic bile ducts
jaundice, cirrhosis, and increased incidence of cholangiocarcinoma

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regenerative nodules

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produce intrasinusoidal HTN

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portal vein formed by

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splenic and superior mesenteric

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hyperestrinism in males

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gynecomastia, spider angiomas

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primary biliary cirrhosis

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AI granulomatous destruction of bile ducts in triads
anti-mitochondrial Abs and IgM

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hemosiderosis

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acquired Iron overload disease

Front 28

cause of hemosiderosis

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multiple blood transfusions (sicke cell and thalassemia pts)
alcohol abuse
well water (iron pipes)

Front 29

cirrhosis BUN and ammonia

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decreased BUN
increased serum ammonia

Front 30

hypocalcemia in cirrhosis

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decreased serum albumin decreases total serum calcium
decreased vitamin D as liver needed to make 25-OH-vit D

Front 31

liver cell adenoma

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anabolics
oral contraceptives
intraperitoneal hemorrhage

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liver mets

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most common cancer of liver
lung is most common primary site

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increased serum AFP

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hepatocellular carcinoma

Front 34

cholesterol gallstones

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increased cholesterol in bile
decreased bile salts and lecithin

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black pigment gallstone

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sign of extravascular hemolysis
calcium bilirubinate

Front 36

brown pigment stones

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sign of common bile duct infection

Front 37

pain radiation in cholecystitis

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right scapula

Front 38

most common cause of acute pancreatitis

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alcohol abuse

Front 39

seat belt trauma

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most common cause of pancreatitis in children

Front 40

serum lipase

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more specific for amylase in pancreatitis

Front 41

persistent increase in serum amylase

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consider pancreatic pseudocyst