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20 Cards in this Set
- Front
- Back
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Hypoxia
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inadequate oxygenation
most common cause is coronary artery atherosclerosis |
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PaO2 and saturation in anemia
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both normal
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MetHb
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Fe3+
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CO poisoning
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normal PaO2
decreased O2 sat treat with 100% O2 |
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CO and Cyanide inhibit
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cytochrome oxidase
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mitochondrial toxins
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alcohol and salicylates
damage inner mit. membrane leading to uncoupling of Ox-phos --> hyperthermia oxidative energy release as heat instead of ATP |
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activates apoptosis
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cytochrome C
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reperfusion injury
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superoxide ion and increased cytosolic calcium lead to damage
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SER hyperplasia leads to
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increased drug metabolism
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ubiquitin
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marker for intermediate filament degradation
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dystrophic calcification
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calcification in necrotic tissue
examples: calcified atheroslcerotic plaque calcification in pancreatitis |
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basal ganglia calcification can occur in
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hypoparathyroidism
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brown atrophy
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tissue discoloration that results from lysosomal accumulation of lipofuscin
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lipofuscin is an indigestible lipid derived from
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lipid peroxidation of cell membranes
this may occur in atrophy and free radical damage of tissue |
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preservation of structural outlines seen in this type of necrosis
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coagulation
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type of necrosis seen in cerebral infarction
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liquefactive
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enzymatic fat necrosis
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acute pancreatitis
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caspases
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group of cysteine proteases that are activated in apoptosis
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BAX gene
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apoptosis gene
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BCL2
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anti-apoptosis gene
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