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14 Cards in this Set
- Front
- Back
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3 receptors for peptic acid disease
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muscarinic, histamine, gastrin
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Acetylcholine activates which receptor?
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muscarinic receptor
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Ex of H2-receptor antagonist
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cimetidine
-similar base to histamine |
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MoA for H2-receptor antagonists
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reversibly compete w/ histamine to inhibit binding on baso-lateral membrane of gastric parietal cells
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Proton pump inhibitors MoA
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irreversibly binds (covalent) and inhibit the H+/K+ ATPase (proton pump) within luminal membrane of gastric parietal cells
-prodrugs (activate in acid environment) |
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Major indication of PPI
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GERD
Peptic ulcer disease Zollinger-Ellison syndrome |
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MoA sucralfate
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extensive cross-linking and polymerization, produces a viscous, sticky gel
-adheres to epithelial cells and ulcer craters -inhibits pepsin-mediated hydrolysis of mucosal proteins |
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What does sucralfate need to function?
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requires acid environment to function
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analog of prostaglandin E1
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misoprostol
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MoA of misoprostol
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binds EP3 receptor of gastric parietal cells to dec cAMP
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side effects of misoprostol
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diarrhea, abdominal cramping
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MoA of antacids
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directly neutralized gastric HCl
(just change acid once it's present) |
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Maalox composition
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Al(OH)3, Mg(OH)2
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side effects of antacids
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diarrhea, constipation
"milk-alkali syndrome"-kill kidneys |
