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28 Cards in this Set
- Front
- Back
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What do all the Proton pump inhibitors end with?
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-razole
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Name 3 proton pump inhibitors?
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Omeprazole, Lansoprazole, Esomeprazole
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T/F PPI get into the systemic circulation to work?
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True-They are enteric coated and get absorbed in the duodenum, they travel via systemic circulation to the parietal cells where they diffuse through. They are activated by H+ ions and bind COVALENTLY to the K+/H+ pump.
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How long on a PPI until there is Acid suppression?
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24hours
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How long until ulcer are healed?
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4 weeks
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Omeprazole inhibits what P-450 Enzyme?
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CYP2C19
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Omeprazole induces P-450 Enzyme?
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CYP1A2
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Name some drug interaction of Omeprazole?
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Warfin, Diazepam, Cyclosporin A
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Increasing the pH of the stomach may affect the availability of which drugs?
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Ampicillin, Ketoconazole
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MOA of H2 blockers?
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They bind to the histamine 2 receptors on the systemic blood side of the parietal cell and competitively inhibit Histamine from binding. This decreases cAMP levels in the parietal cell thus decreasing H+
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Name some H2 antagonist?
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Cimetidine, ranitidine, Famotidine, nizatidine
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All the H2 blockers end in?
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-tidine
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What is the problem with the first H2 blocker that was made?
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One took it 4x daily and it caused antiandrogen effects such has gynecomastia, galactorrhea, and reduced sperm count
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Sucralfate
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Sulfated Polysaccharide
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Bismuth
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Colloidal Bismuth Compound
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Misoprostol
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Prostaglandin analogue: Synthetic analogue of PGE1
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Sucralfate Mechanism of Action
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In acid environment, pH<4, undergoes extensive cross-linking
Produces a viscous, sticky polymer that adheres to epithelial cells and ulcer craters Inhibits the pepsin |
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Avoid in patients with renal failure who are at risk for aluminum overload
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Sucralfate
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Formation of bezoars(ball), especially in patients with gastroparesis
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Sucralfate
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Why should you give other medication 1 hour before you give sucralfate?
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bc sucralfate will form a barrier around the stomach and/or small int. therefore other drugs can not be absorbed
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____ and ____ are the major PGs synthesized by gastric mucosa
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PGE2/PGI2
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Misoprostol Mechanism of Action
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Synthetic analogue of PGE1
Promotes secretion of mucus and bicarbonate eg. cytoprotective Degree of inhibition of gastric acid secretion is directly related to the dose |
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What is the major adverse effect of Misoprostol
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Diarrhea in 30% of patients
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What condition is misoprostol condraindicated in and why?
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Inflammatory bowel disease: exacerbation
Pregnancy: stimulates uterine contractility |
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MOA of Bismuth?
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Creates a protective coat over ulcer, increases Prostaglandin secretion, antimicrobial effect on H. Pylori, inhibits pepsin
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Black stools / Black tongue (harmless)
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Bismuth
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Avoid in patients with asprin hypersensitivity
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Bismuth
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Salicylate toxicity with high doses
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Bismuth
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