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28 Cards in this Set
- Front
- Back
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what is dysentery?
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this dirrhea due to inflam of the large bowel that is usually accompanied by mucous, blood, and abdominal pain
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what kind of diarrhea does shigella prod?
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mucusy, bloody, pus
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what are the two organisms that give you inflam diarrhea?
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shigella and salmonella
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What is the infectious portion of shigella that invades cells and causes apop?
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shiga toxin
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what is the steps to death for the shiga toxin
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1. shigella binds to G3b and injects shiga toxin
2. to golgi--> to ER 3. into the cytosol where it cleaves a single adenosine subunit of the 28s of the 60s ribosome 4. misfolded proteins occur and this signals the cell for apoptosis. |
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How is shigella easily transmitted?
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it has the ability to infect with small number of organisms because it can resist the stomach acid
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what species of shigella is the worst and most common?
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S. dysenteriae
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what is the cell shigella uses as an entery?
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M-cell
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What IL recruite PMN to battle shigella and where do they come from?
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IL-18 and IL-1b from macrophages and IL-8 from infected enterocytes
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what features make m-cells more accesible to shigella?
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theur reduced glycocalyx and rudimentary brush border
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describe shigella
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gram - bacillus that is non-motile and facultative anaerobe
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if you get a methylene blue stain positive fecal material what organisms could it be?
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shigella or salmonella
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what is the route of spread for salmonella?
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fecal oral
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what part of the GI does salmonella infect?
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ileum
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what are the 2 syndromes of salmonella?
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gastroenteritis and typhoid fever
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what part of the GI does salmonella infect?
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ileum
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what are the 2 clinical features of salmonella?
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gastroenteritis and typhoid fever
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what part of salmonella allows it to evade phagocytosis?
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Virulence capsule (Vi)
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what are the 2 strain of salmonella that can cause typhoid fever?
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typhi and paratyphi
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what allows for some people to be life long carriers of salmonella?
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it invades and resides in the gall bladder
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can salmonella be deteced in urine and feces?
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yes
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what is the pathogenesis behind salmonella?
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1. binds to enterocyte and via type 3 secretion it injects proteins into the cell
2. the cell cytoskeleton becomes weak and salmonella can get in 3. resides in cavoules and reproduces 4. escapes and kills the cell 5. gets in macrophages and goes to mesenteric lymph nodes and spreads from there. |
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what TLR ligands does salmonella contain?
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flagellin that activates TLR 5 and LPS that activates TLR4.
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The activation of TLR causes an increase in what?
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NF-kB
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what species of salmonella survive in macrophages?
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typhi and paratyphi
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Describe salmonella
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gram - bacillus that is motile and facultative anaerobe
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what is the treatment for gastroenteritis casued by salmonella?
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supportive
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what is the tx for typhoid fever caused by salmonella?
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ABX
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