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14 Cards in this Set
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- 3rd side (hint)
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Cimetidine
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Reversible H2 Blocker.
AE: P450 Inhibitor. Anti-androgenic. Cross BBB (confusion, etc). Decrease Creatinine excretion. |
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Omeprazole
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Irreversibly inhibts ACTIVE pumps.
P450 clearance and INHIBITION. Prodrugs must be pronated in cells. |
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Bismuth. Sucralafate.
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Bind to ucler base, providing physical protrection. Allow HCO3 secretion to reestablish pH gradient in mucous.
Also anti-Diarrhea. Part of H. pylori triple therapy. |
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Misoprostol
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Prostaglandin analog.
SE: Diarrhea. Contraindicated in childbearing women. |
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Pirenzepine, Propantheline.
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Muscarinic antagonists (M1 on ECL cells and M3 on parietal cells).
SE: Tachycardia, dry mouth, cycloplegia. |
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Loperimide
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Opioid anti-diarrheal.
Excluded from CNS by mdr transporter. SE: cIx in children. |
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Sulfasalazine
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Sulfapyridine (antibacterial) + Mesalanine (anti-inflammatory). Activated by colonic bacteria.
SE: Malaise, nausea, sulfonamide toxicity, oligospermia (reversible). |
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Ondansetron
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Antiemeic. 5HT3 antagonist.
SE: Headache, Constiplation. |
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Antacids in general
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Can effect absorption, bioavailablity, urinary excretion of other drugs by changing gastric pH or delaying gastric emptying.
Cause systemic alkalosis, hypokalemia. |
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Aluminum Hydroxide
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Antacid.
SE: Constipation, hypophospahtemia, proximal muscle weakness, osteodystrophy, seizures |
MINIMUM feces.
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Magnesium Hydroxide
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Antacid.
SE: Diarrhea (osmotic), hyporeflexia, hypotension, cardiac arrest. |
Mg=Must Go to the bathroom
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Calcium Carbonate
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Antacid.
SE: Hypercalcemia, REBOUND ACID INCREASE. Also, can chelate and decrease effectiveness of other drugs (Tetracyclines). |
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Cisapride
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Prokinetic Agent.
5HT receptors to increase ACh release at the myenteric plexus. Increase esophageal tone; increase gastric/duodenal contractitlity. SE: NO LONGER USED. TORSADES DES POINTES when given with erythromycin, ketoconazole, flucanazole, nefazodone. |
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Metoclopramide
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D2 receptor antagonist. Increases resting tone, contractility, LES tones, motility. DOES NOT influence colon transport time.
Used for gastroparesis (DM and post surgery). SE: Increases Parkinsonian effects. Interacts with digoxin and DM agents. cIx if small bowel obstructed. |
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