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30 Cards in this Set

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4 H2 blockers
cimetidine, ranitidine, famotidine, nizatidine
MOA of H2 blockers
reversibly block H2 receptors which causes decreased H+ secretion by gastric parietal cells
cimetidine toxicities
P450 inhibitor; antiandrogenic; crosses BBB (confusion, HAs, dizziness) and placenta
None
2 proton pump inhibitors
omeprazole, lansoprazole
MOA of PPIs
irreversibly bind H+/K+ ATPase in gastric parietal cells
MOA of bismuth, sucralfate
bind to ulcer base and provide physical protection, allow bicarb secretion to reestablish pH gradient in mucous layer
triple tx of H. pylori?
metronidazole + bismuth + amoxicilin/tetracycline
MOA of misoprostol
PGE1 analog, that increases production and secretion of gastric mucous barrier and decreases acid production
toxicity/contraindications for misoprostol
(PGE1 analog) diarrhea, not for women of childbearing potential
which 2 muscarinic antagonists used for treatment of peptic ulcer?
pirenzepine, propantheline
toxicities of pirenzepine and propantheline?
tachycardia, dry mouth, difficulty focusing eyes
overuse of aluminum hydroxide can cause what problems?
(antacid) constipation, hypophosphatemia, proximal mm weakness, osteodystrophy, seizures
overuse of magnesium hydroxide can cause what problems?
(antacid) diarrhea, hyporeflexia, hypotension, cardiac arrest
overuse of calcium carbonate can cause what problems?
(antacid)hypercalcemia, rebound acid increase
MOA of infliximab
monoclonal TNF-alpha ab
clinical use of infliximab
Crohn's dz, rheumatoid arthritis
infliximab toxicity
respiratory infection, fever, hypotension
MOA sulfasalazine
combo antibacterial (sulfapyridine) and anti-inflammatory (mesalamine); activated by colonic bacteria
clinical use of sulfasalazine
UC, Crohn's disease
toxicity of sulfasalazine (5)
malaise, nausea, sulfonamide toxicity, reversible oligospermia
MOA of ondansetron
5-HT3 antagonist (powerful central acting anti emetic)
clinical use of ondansetron
antiemetic; to control vomiting post-op and in pts undergoing chemotherapy
toxicity of ondansetron
headache, constipation
MOA of cisapride
acts thru serotoni R to increase Ach release at myenteric plexus; increases esophageal tone; increases gastric and duodenal contracitlity and improves transit time (prokinetic)
Clinical use of cisapride
prokinetic (on GIT) but no longer used because of serious interactions with erythromycin, ketoconazole, nefazodone, fluconazole (-->torsades de pointes!)
MOA of metoclopramide
D2 R antagonist; increases resting tone, contractility, LES tone, motility but does not increase transit time thru colon. (pro-kinetic)
clinical use of metoclopramide
diabetic and post-surgery gastroparesis
toxicity of metoclopramide
(D2 R antag). Increased Parkinsonian effects; restlessness, drowsiness, fatigue, depression, nausea, constipation.
drug interactions of metoclopramide
digoxin and diabetic agents
contraindications for metoclopramide?
(D2 R antag) pts with small bowel obstruction