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7 Cards in this Set
- Front
- Back
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Aggro factors
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1. gastric acid
2. pepsin 3. h. pylori |
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Cytoprot agents
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1. bicarb
2. mucus 3. PGs |
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His-2 blockers
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1. Cimetidine
2. Ranitidine 3. Famotidine 4. Nizatidine 5. Zolentidine |
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Cimetidine v. other H2 blockers
Diffs: |
Diffs:
1. ZE syndrome tx 2. imidazole ring 3. > SE |
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All H2 blockers
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Sims:
1. 50% bioavail except Nizitidine (90%) 2. no fx on vasc/sm mm 3. decrease basal/noct acid secretn 4. dose-dep manner 5. dep on renal fnctn (normal creatine lvls may mask poor renal Cl in old ppl) |
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Structure of H2 blockers
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1. Cimitidine = imidazole
2. Ranitidine = furan 3. Nizitidine + Famotidine = Thiol |
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Zolentidine: what's so special about it?
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hi lipophil so can cross BBB to blk h2r on CNS
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