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12 Cards in this Set
- Front
- Back
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What is the chief clinical sign of alcoholic liver dz?
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rapid onset of jaundice; may be accompanied by fever, ascites, and encephalopathy.
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Is Cholestasis a more common finding in alcoholic hepatitis or nonalcoholic steatohepatitis (NASH)?
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alcoholic hepatitis
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Labs:
Serum AST 2x ULN AST:ALT ratio > 2 Total serum bili >5mg/dL elevated INR neutrophilia What might these findings suggest in a pt with an appropriate history? |
Alcoholic hepatitis
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Clumps of ropey eosinophilic material w/i hepatocyte cytoplasm are called...
Are they specific to alcoholic liver dz? |
Mallory's hylain/bodies
No. |
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Which of the following raise the risk of Metabolic syndrome, which in turn is a major risk factor for NAFLD?
Central Obesity Elevated Serum insulin Dyslipidemia HTN |
All
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AST:ALT ratio >2 suggests what? <1?
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ALD; NAFLD
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Can AST & ALT be normal in ALD? NAFLD?
Is NASH/NAFLD dx'ed in a particular way? Are AlkPhos lvls elevated in NAFLD pts? If so, how much typically? |
Yes, they can be, but they can also be elevated up to 10-fold.
yes, by exculsion. Yes, usually <2-3 times normal. |
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What is the gold standard for Dx of NAFLD/NASH?
Can noninvasive imaging studies distinguish between benign steatosis and steatohepatitis? |
Liver biopsy.
No. |
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A diffusely scarred liver is said to be....
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cirrhotic.
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What are the 4 CAGE questions?
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Have you ever felt the need to cut down on your drinking/drug use?
Have you ever been Annoyed at criticism of your drinking/drug use? Have you ever felt guilty about something you've done when you've been drinking/high? Have you ever had a morning eye-opener - taken something to get going or to treat withdrawal sx? |
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What should be first on our minds in liver dz?
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Drugs/Alcohol.
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Elevated MCV
Increased Iron & amylase Elevated liver enzymes ^TriG What do these suggest? |
Lab "hints" for alcohol abuse
"MILT" |
