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10 Cards in this Set
- Front
- Back
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What is the largest risk factor for HCV?
How do we define SVR in HCV infection? How do we tx HCV? Which genotypes must be treated longer? shorter? |
Injection drugs.
the absence of HCV RNA in serum by PCR or other sensitive test at the end of treatment and 6 months later Peg-interferon + Ribavirin 1,4; 2,3 |
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What signal's the body's own Interferon systems?
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dsRNA --> sign of viral infection
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What is the advantage of pegylated interferon?
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addition of polyethylene glycol to the interferon molecule enhances its biologic activity and extends its half-life
Pegylated interferon has improved pharmacokinetics (absorption, plasma half-life) |
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What is ribavirin?
- side effects? - contraindications? |
purine nucleoside analog
- anemia, fatigue, itching, sking rash, nasal stuffiness, sinusitis, and cough - pregnancy (concern of birth defects) |
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What are the major side effects of interferon?
In which pts might epoein-a be helpful? |
Neuropsychiatric symptoms (depression)
Influenza-like symptoms Hematologic abnormalities-(bone marrow suppression) those w/ substantial cytopenia |
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Which of the following are established predictors of response to PEG IFN/Ribavirin tx?
Genotype Viral load Race Fibrosis Body weight Age Gender |
all of 'em.
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Which new class of drugs hold promise for future HCV tx?
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Protease inhibitors (PI's)
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Severe psychiatric illness
Alcohol or substance abuse Co-morbid conditions such as renal disease Clinically decompensated cirrhosis because of hepaptitis C Kidney, liver, heart or other solid-organ transplant What do these have to do with HCV tx? |
they are exclusionary factors for tx.
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HBV is a DNA virus, and HCV is a RNA virus... which has RT activity?
What is the implication of that for tx? |
Both do! Hepadnaviruses replicate their DNA genomes by means of an RNA intermediate.
Reverse transcriptase inhibitors can therefore be effective therapies for both |
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Lamivudine and Adefovir are what?
- to which does resistance occur more quickly? - are they both well tolerated? |
nucleoside/nucleotide HBV drugs
Lamivudine Yes |
