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5 Cards in this Set
- Front
- Back
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Linkage (define phase)
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Linked markers are inherited as a set
Markers on same chromosome are "in phase" If a marker is linked to a trait, all affected individuals will have marker |
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LOD score
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Log of Odds score
>= 3 : 2 loci are close < -2.0 : excludes evidence of linkage |
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Recombination frequency
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# offspring w/ loci out of phase(recombinant offspring)/total # offspring
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Linkage disequilibrium
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Linked characteristics are in LD
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Red flags for hereditary cancer (6)
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Early onset (<50)
Multiple or bilateral tumors Rare or unusual tumors Certain combinations of cancers AD pattern of inheritance Lack of known contributing factors |
