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40 Cards in this Set

  • Front
  • Back
What is the classification of Streptococcus?
-Gram positive
-arrange in chains
-Lancefield (group A)
Explain Strep vs. Staph

-both are catalase
Why is S.Pyogenes so sucessful as a pathogen
because of it's ability to colonize, multiply, and spread, while evading phagocytosis and confusing the immune system.
What components make up S.Pyogenes?
-group A carbohydrates
-M protein
What is the role of protein G
and C5 peptidase?
it binds to the wrong end of an antibody.
-C5 pep: inhibits C5 used for inflammation
What are 2 adherence factors of Strep
-lipoteichoic acid (makes them sticky and interact with fibronectin.)
-Protein F (also binds to fibronectin)
What is the importance of Streptokinase?
-it dissolves blood clots
-this aids the bacteria to enter the host by dissolving clots created by the body to block entrance
What toxins are produce by strep.
Pyrogenic exotoxins
(fever producing)
How does "Streptolysin O" aid in the spread of Strep bacteria?
It forms pores in leukocytes,tissue and platelets.
What is Streptococcal pharyngitis?
-group A
-and it is supperative(pus)
Why isn't there a vaccine for Streptococcal Pharyngitis?
Because there are 100's of M-proteins and that means you would have to get all of them approved by the FDA (unlikely)
What are two nonsupperative Strep. diseases?
-Acute Rheumatic fever
-Acute glomerulonephritis
How do you get Rheumatic fever?
Your body builds an immune to M-proteins and since these proteins are in the heart then you can send Ab to your heart thus activating the completment system(inflammation and heart disease)
Why is a Rheumatic Fever recurrent in previously infected individuals.
because the next time Ab will react even faster thus the complement system on the heart is faster. (life-long prophalaxsis is needed)
What are the symtoms of Rheumatic Fever?
Inflammation of various tissues including joints, heart, skin, and brain.
What is the incubation period for rheumatic heart disease?
1-4 weeks after a Strep throat infection
How does Endocarditis occur in the heart?
By the formation of clots in the heart thus giving bacteria a place to grow.
what is the best step in the prevention of Rheumatic Heart Disease?
Getting rid of the strep before your body starts an immune response.(which then complement immunity attacks the heart)
What test are used to test for Strep?
-Latex bead agglutination
How does an individual aquire Acute Glomerulonephritis
By the activation of the complement system by bacterial components deposited on in the kidney
(second attacks are rare)
What is Scarlet Fever?
-Streptococcal pharyngitis with a rash.
-Erythrogenic Toxin (reddening of tongue)
what kind of infection is Impetigo?
Either a Staph.Aureus or a S.Pyogenes infection of the skin.(usually around the mouth)
Why is Flesh-eating bateria so deadly and has little pus?
Because it spreads so fast that there is little time for recruitment of luekocyctes and Ab's to the site.
What is the estimated life expectancy of someone affected with a flesh-eating bacteria?
24-48 hours
What are the symptoms of Necrotizing Fascitis?
-flu-like symptoms
-pain (excruciating)
What is the treatment of Necrotizing Fascitis?
Getting the infected tissue out of the body then treating with antibiotics.
Discribe a Group B Strep and where is it found?
-Stretococcus Agalactiae
-this colonize the lower GI and GU tracts
Why is S.Agalactiae so critcal in pregnant women?
because it causes Neonatal sepsis and meningitis. Women screened in trimester.
What is the difference in alpha and beta-Hemolysis?
Alpha: incomplete hemolysis

beta: complete hemolysis
What is the form of S.Pneumoniae and how many varations are there of this form?
-84 different versions of capsulated form
How does S.Pneumonia occur in the body?
When the normal colonization in the nose and throat spread to places they shouldn't.(due to increase in mucos secreations-cold)
What is pneumococcol pneumonia?
Community acquired pneumonia.
What must bacteria overcome to multiply in the lungs?
The alveolar macrophages
How does Pneumococcal Pneumonia get into the lungs?
-alcohol(changes mucus)
-old age(can't cough as much)
Then they grow rapidly in the edema fluid
What other disease can occur from the traveling of bactria in the blood stream?
-septic arthritis
-sinusitis and otitis media
What is pathogenesis?
disease cause by multiplication of bacteria in tissue.
How do you test Pneumonia patients for bacteria?
Sputum sample (need exudate)
Typically what streps are found in the mouth?
Viridans Strep
(greening strep)
-subacute bacterial endocarditis
Name Group A Strep.
What strep is non groupable?