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24 Cards in this Set
- Front
- Back
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MOA for H2 antagonists
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block H2 receptors on the basolateral membrane of parietal cells, inhibits cAMP which leads to decreased stimulation of HK atpase
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What drugs lead to an increased risk for pneumonia
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PPIs, omeprazole
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What are the side effects of cimetidine?
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p450 inhibition and antiandrogen effects
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MOA of misoprotosol
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stimulates EP receptor on epithelial cell---increase mucus
stimulate EP3 on parietal to decrease acid via blocking adenyl cyclase via Gi |
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Big side effect of misoprostol?
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diarrhea, high incidence
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TX for eradicating H pylori?
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Amoxicillin or metronidazole
clarithromycin PPI |
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Antiulcer agent contraindicated in pregnancy?
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misoprostol
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What would you use for zollinger ellison syndrome
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omeprazole
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What would you use to counteract vinblastine or metheotrexate?
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dexamethasone
alt-prochloroperazine |
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If someone was one cyclophosphamide, what else would you give them?
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dexamethasone and palonosetron
alt- NK antag (aprepitant) |
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To combat NV with someone taking cisplatin, you'd use?
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dexamethasone, a setron, aprepitant
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Your chemo patient has NV despite optimal tx, whats the last try?
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high dose metoclopramide instead of setron
or D2 antag or cannabinoids |
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what antiulcer agent is contraindicated in pregnancy?
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misoprostol
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what antiulcer agent can cause constipation?
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sucralfate
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MOA of scopolamine?
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M blocker
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MOA of Dimenhydrinate and Promethazine?
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H1 receptor antagonists...vestibular apparatus cant communicate with vomit center
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Phenothiazine (prochloperazine) MOA?
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D2 blocker in CTZ to prevent NV and blocks D2 in gut to prevent dysmotility
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whats the 5-ASA drug
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mesasalamine
or sulfasalzine |
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Can sulfasalazine tx severe UC or CD?
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NOPE
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what can cause folic acid defiency in IBD drugs?
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sulfasalazine...the sulfapyridine part
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You want to tx mild CD or UC, whats your tx plan
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use 5-ASA...alternative is ABX for CD or corticosteroids
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After txing mild CD or UC, what the tx plan for maintaining the remission
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5-ASA...alternative is MTX, 6MP AZA, inflixamab
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you want to tx severe CD or UC, whats the tx plan
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steroids (budesinone)...alternative is MTX or cyclosporine, or infliximab
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you want to maintain remission after treating severe CD or UC, whats the tx plan
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only options
MTX, 6MP AZA, or infliximab |
