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7 Cards in this Set
- Front
- Back
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Theories of action |
Lipid theory - relationship between lipid solubility and anaesthetic potency (higher the lipid solubility the greater the potency) Water theory - anaesthetic molecules produce an iceberg which disrupts the function of the cells Protein theory - ligand binding to gated ion channels causing the anaesthetic effect |
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Stages of anesthetic |
Analgesia Excitement Surgical anesthesia Medullary depression |
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Two groups of GA |
Inhalation (volatile and gaseous) Intravenous |
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Minimum alveolar concentration |
Minimum alveolar concentration that is able to lead to 50 percent of people to become immobile when exposed to a noxious stimulus Comparative tool |
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Volatile drugs |
Halothane - not analgesic, inadequate muscle relaxation, inhibits SNS response to pain, bronchi dilation, hypotension due to depression of myocardium and vasomotor centres - can lead to malignant hyperthermia Enflurane - less potent than Halothane - muscle relaxation, however post operative seizures Isoflurane - least potent - increased coronary heart attack - can cause malignant hyperthermia |
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Gaseous drugs |
Nitrous oxide - low potency - rapid onset - minimal effects on respiratory drive - euphoria |
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Intravenous drugs |
Thiopentone - high lipid solubility - member of the barbiturate family - the action of this drug is terminated as they are distributed into fat depots - poor analgesic - Propofol - rapid onset and rapidly metabolised - |
