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8 Cards in this Set
- Front
- Back
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Fungi
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-maj of time destroy cell wall; made out of ergosterol
-make hole in cell wall; silo -or inhibit production of ergosterol |
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Amphotericin B
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-key drug
Interact with ergosterol in fungal cell membrane to form pores - disrupt the membrane permeability -used for any type, but lots of side effects, IV -NO BBB crossing, therefore systemic DOC! -key SEVERE nephrotoxicity (worse drug of all drugs for kidneys) |
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Nystatin
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MOA is similar to amphotericin B
Nystatin too toxic for systemic use --Used topically in candidiasis -EVEN more nephrotoxic, used topically DOC! |
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Azoles
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Ketoconazole, Fluconazole, Itraconazole
-MOA Interfere with the synthesis of ergosterol by inhibiting 14-a-demethylase which converts lanosterol (estrogen in human) to ergosterol (cholesterol in humans)- most important fact! cytochome p450 inhibitor; drug toxicity or therapeutic failure |
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Fluconazole
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Well absorbed orally, enters CNS
Least effect on liver enzymes DOC for meningitis!!!!! |
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Griseofulvin
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Binds to microtubules comprising the spindles and inhibits mitosis
Incorporates into affected keratin : fungistatic Spectrum: dermatophytes only (sub cutaneous use!) Dermatophyte infection of skin, nail, hair, feet despite given orally, RING WORMS! aswell -CONTRAINDICATED IN PREGO! |
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Flucytosine
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-prodrug, converted to 5-flucytosine
-Inhibition of DNA synthesis -adverse; Bone marrow suppression |
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Terbinafine
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DOC of pityriasis versicolor
“christmas tree rash” Lower back or on chest Feels like it goes and comes away (but have it all the time), little white discoloration, with tan see it better |
