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49 Cards in this Set

  • Front
  • Back
Myeloid stem cells give rise to?
Myeloblasts(precursor of neurophils, eosinophils,basophils)
Monoblasts(monocytes)
Megakaryoblast (platelet)
What is polycythemia?
increased # RBCs
(seen in thalasemmias)
How does the erythyrocyte get energy?
Glucose(90% anaeroically degraded to lactate; 10% by HMP shunt)
What 4 things do basophils contain?
1. heparin
2. histamine
3.other vasoactive amines
4. leukotrienes (LTD-4)
5 causes of eosinophilia:
1. Neoplastic
2. Anemia
3. Allergy
4. Collagen vascular disease
5. Parasites
NAACP
2 markers on B cells.
CD19
CD20
T cell markers.
CD3 + either CD4 or CD8.
MHC1 = CD8,
MHC2 = CD4
What does Factor V Leiden cause?
Resistance to activated protein C (Can't inhibit coagulation).
Spherocytes
Hereditary spherocytosis
Autoimmune hemolysis
Helmet cell, schistocyte
DIC
Traumatic hemolysis
Teardrop cell
Myeloid metapasia with myelofibrosis
Acanthocyte
Spiny appearnce in abetalipoproteinemia
Target cells.
HALT
HbC disease
Asplenia
Liver Disease
Thalassemia
Poikilocytes
Nonuniform shapes.
Seen in:
TTP/HUS
Microvascular damage
DIC
Burr cell
TTP
HUS
Psammoma body
Laminated, concentric, calcific spherules seen ins
Papillary adenocarcinoma of thyroid
Serous ovary
Meningioma
Mesothelioma
Order of hematopoiesis
1. Yolk sac (3 weeks)
2. Liver (1 mon-7 mon)
3. Spleen/lymphatic (2-4 mon)
4. Bone marrow (>4 mon)
Microcytic anemia
Iron def.
Thalassemias
Lead poisoning
Sideroblastic anemia
What is a sign of RBC hemolysis?
Decreased haptoglobin and
increased serum LDH.
Crew cut appearnce of skull on x-ray?
Sickle cell
beta-thalassemia
Way to expand marrow d/t decreased RBC lifespan.
Signs of hemolytic anemia
1. increased bilirubin
2. jaundice
3. pigment gallstones
4. increased retic ct
Warm agglutinin is Ig_
cold agglutins is Ig_
Warm - IgG
Cold - IgM
Hereditary spherocytosis
extravascular hemolysis d/t spectrin/ankyrin defect.
Paroxysmal nocturnal hemoglobinuria
Intravascular hemolysis due to membrane defect. Increased RBC sensitivity to complement.
Increased urine hemosiderin.
7 causes of DIC
1. Sepsis
2. Trauma
3. Obstetric
4. Acute Pancreatitis
5. Malignancy
6. Nephroic syndrome
6. Transfusion
(STOP Making New Thrombii)
Bernard-Soulier disease
Decreased GP Ib. defect in platelet adhesion
Glanzmann's thrombasthenia
defect in platelet aggregation (decreased GP IIb-IIIa)
Hodgkins' Lymphoma
RS cells (CD30+, CD15+)
Contiguous spread
Mediastinal lyhmphadenopathy
50% assoc c EBV
More common in men except for nodular sclerosing type.
Non-Hodgkin's lymphoma
Assoc with HIV and Immunosuppresion
Noncontiguous spread
Fewer constiuttions s/s.
Peak incidence 20-40
Multiple myeloma
Monoclonal plasma cell
Fried egg appearnce
IgG
Punched-out lytic bone lesions
Bence Jones (light chains in urine)
Rouleau formation
Follicular lymphoma (non-hodgkins) chromosome
t(14:18)
blc-2 expression
Mantle cell lymphoma (NH) chromosome
t(11:14)
Cd5+ = poor prognosis
Burkitt's lymphoma(NH)
t(8,14)
c-myc
Starry-sky appearance
t(9,22)
Philadelphia
CML
bcr-abl hybrid
t(14;18)
Follicular lymphoma (NH)
bcl-2 activation
t(15;17)
M3 type of AML
Acute promyelocytic leukemia
Responds to all-trans-retinoic acid
t(11;22)
Ewing's sarcome
t(11:14)
Mantle cell lymphoma
Auer rods
AML
Smudge cells
CLL
TRAP stain
Hairy cell leukemia (B cell)
L1
ALL - null
L2
T-cells
L3
B cells
M2 and M3
Neurophils and basophils
M4 and M5
Monocytes
M6
erythyrocytes
M7
platelets
Histiocytosis X
Langerhans cells infiltrate lung.
Young adults.
Worse with smoking