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65 Cards in this Set

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Upper Respiratory Tract Infections (URIs): 7

Viral pharyngitis Bacterial pharyngitis The common cold Viral tonsillitis Bacterial tonsillitis Rhinitis Sinusitis

Respiratory Syncytial Virus (RSV)

supportive tx

Bronchiolitis. viral or bacterial?

mostly viral

Croup: most common age/gender, upper or lower airway?

young boys, upper airway

Pertussis: age at risk and prevention?

"whooping cough" kids prevent: immunizations

Cystic fibrosis

cf

Asthma

step 1-6. questions based on severity. cannot dx the level during an acute exacerbation. will get a scenario of a pt and have to tell severity and what will prescribe.

Pneumonia: atypical: who's at risk? CAP: who's at risk and tx:

atypical: young adults get this CAP: children from : virus: RSV children Bacterial - adults: 20-60% Strep pnm 10-15% H flu B lactam PLUS Macrolid (azithromycin) or Fluoroquinolone

The common cold:

viral URI sneezing, malaise, watery nasal discharge, mild sore throat, +/- fever tx: NO antibiotic. tx pain and fever

The FDA recommendations for <6yo cold/cough meds

Recommended that oral OTC cough and cold ingredients should no longer be available for children under 6 years of age

Most frequent cause of hospitalizations of infants?

bronchiolitis

Causes of Bronchiolitis

predominately viral RSV >50% of cases

pathophysiology of bronchiolitis:

Bronchiolar obstruction due to edema Accumulation of mucus and cellular debris Invasion of the smaller bronchial tubes by virus Ball valve respiratory obstruction leading to air trapping and overinflation

RSV symptoms

Pharyngitis, +/- fever, occasionally otitis media, coryza, bronchitis/bronchiolitis, pneumonia

Croup caused from and s/s

viruses laryngotracheobronchitis symptoms worse at night inspiratory stridor

Pertussis: organism and s/s

"whooping" cough organism: bordatella pertussis cough starts as a dry intermittent hack post tussive emesis is common

Pertussis tx:

erythromycin

Cystic Fibrosis

multisystem genetic disorder: GI, COPD, exocrine dysfunction, malabsorbtion of nutrients by pancreas

PNM: 3 types

Lobar Interstitial Bronchopneumonia

Lobar PNM:

involves depositions in the alveolar space that result in consolidation all or part of a lobe of the lung

Interstitial PNM:

cellular infiltrates attack the interstitium, which makes up the walls of the alveoli, the alveolar sacs and ducts, and the bronchioles (typical of acute viral infections)

Bronchopneumonia PNM:

inflammation is centered in the bronchioles and is characterized by mucopurulent exudate->patchy consolidation involves more than 1 lobe

causes of PNM:

viral or bacterial RSV, flu, adenovirus, parainfluenza

S/S PNM:

high fever, cough/wheezing/stridor, restlessness, chills, nasal flaring, grunting, retractions, tachypnea, abd pain

Viral PNM tx:

antipyretics, hydration, rest can use amoxacillin

Asthma defined as:

an immunohistopathologic response

asthma described:

This response produces shedding of airway epithelium, edema, mast cell activation, and inflammatory infiltration by eosinophils, lymphocytes, and neutrophils The result: airway inflammation, acute bronchospasm, airway edema, mucus plugs

dx asthma: 5 years or older

Spirometry: gold standard An increase in FEV1 of ≥12 percent from baseline or An increase ≥10 percent of predicted FEV1 after inhalation of a short-acting bronchodilator

Classifications of Asthma

Step 1: Intermittent Step 2: Mild persistent Step 3: Moderate Persistent Step 4: Severe Persistent

Intermittent:

Symptoms ≤ 2× per week Nighttime symptoms ≤ 2× per month No interference with normal activity FEV1/FVC normal

Mild persistent

Symptoms >2 days/ week but not daily Nighttime asthma symptoms 3-4× per month Minor limitation to activity FEV1/FVC normal

Moderate persistant

Daily symptoms Nighttime asthma symptoms >1× per week but not nightly FEV1/FVC reduced 5%

Severe persistant

Symptoms throughout the day Often 7×/week night time wakening FEV1/FVC reduced >5%

management of asthma

for tx: tx at the level they present to rapidly control symptoms and then taper down to achieve control of symptoms.

what is the most common cause of childhood hospitalization?

asthma

Pharmacological tx for asthma, quick-relief meds:

short acting beta 2 agonist (SABA): albuterol, levalbuterol Inhaled anticholinergics: atrovent systemic corticosteroids: mythylprednisone/prednisone

Pharmacological Therapy: Long-Term Control Medications

corticosterids inhaled: flovent long acting inhaled beta 2 agonist: LABA

do not use ___ in acute exacerbations

long acting B2 antagonists

IH vs IV

Of note, studies suggest that if patients do not respond to inhaled they won't respond to parenteral Epinephrine 1:1000 (1mg.ml) – 0.3-0.5 q 20 min SQ × 3 doses Terbutaline (1mg/ml) – 0.25mg q 20 min SQ × 3 doses

Role of anticholinergics

Meta-analysis reviewed 10 studies- modest improvement in PFT’s noted and significant decrease in hospitalization rates noted

recommendations for systemic corticosteroids:

Recommended for most patients. Early treatment with corticosteroids dramatically reduces need for hospitalization and probably reduces the likelihood of death from acute asthma. Recommended if not responding to β2 agonists

Magnesium

Intravenous has bronchodilator activity in acute asthma Magnesium 2 GMs over 20 minutes Safe Contraindicated in renal insufficiency

Not recommended for asthma tx:

mucolytics, abx,

predictor of hospitalization:

FEV1 and s/s scores 1 hour after initial tx improve ability to predict need for hospitalization

Community Acquired PNM

Associated with at least 2 symptoms of acute infection Fever or Hypothermia Diaphoresis Shaking chills Cough with or without sputum production, or change in the color of sputum in a patient with chronic cough, pleuritic chest pain or dyspnea

Who's at risk for CAP?

<2 yo and >65 yo bc decreased immunity

CAP : s/s

decreased appetite, cough, fever, dypsnea, elderly who are around young children

CAP caused by what organisms: adults children

20-60% Strep pnm 10-15% H flu leading cause in children: RSV

Strep pnm usually causes what type of pnm?

lobular

s/s pnm in elderly:

mental status changes or increased resp rate

if have CAP and pregnant, tx with:

B lactam PLUS Macrolid Do not use fluoroquinolones in pregnancy if preg don't use fluoro or you may hurt the baby

CAP and not pregnant, tx:

B lactam PLUS Macrolid (azithromycin) or Fluoroquinolone

CURB-65: 1 point for everything they have: if confusion, 1 point. admission consideration criteria

Confusion (new disorientation to person, time and place) Elevation of Blood Urea Nitrogen (BUN) Level above 7mmol/L(urea) or 20mg% BUN Respiratory rate over 30 breaths/min Low BP ( Age >65 years 1 point for each criteria-consider admission for score >2

Atypical Pneumonia pathogen

Atypical Pathogen: not a bacteria. not a cocci or bacillus. They are obligate intracellular organisms that need to live inside our cells.

Atypical Pneumonia s/s

No evidence of lung consolidation on physical examination or radiographic examination. Radiographic findings are patchy infiltrate if anything. known as walking mans pneumonia More diffuse illness. low grade fever, cough, upper resp symptoms.

atypical pnm types:

Mycoplasma Pneumoniae Chlamydophila Pneumoniae Legionella pnm

Legionella Pneumphila

pnm with hyponatremia, bradycardia

What is the definition of Hospital Acquired Pneumonia (HAP)?

occurs 48 hours or more after admission. There was no evidence of incubating pneumonia at the time of admission.

What causative pathogens do you need to consider for a patient with HAP?

Aerobic gram-negative bacilli P. aeurginosa, E. coli, Klebsiella pneumoniae, Acinetobacter spp. Gram positive cocci Staphylococcus aures, MRSA (MRSA can be hospital acquired or community acquired.. which are different resistance) Oral bacteria Streptococcus virdins

Early and Late Onset of HAP or VAP prognosis

Early onset of HAP or VAP (Ventilator Acquired PNA) Occurs in first 4 days of hospitalization Late onset HAP or VAP Poor prognosis Higher mortality rate

HAP tx for early onset and no known risk factors for MDRP

Ceftriaxone Levofloxacin ampicillin Ertapenem

Late onset or risk for MDRP: Pathogen and tx

acinetobacter tx: cefepime, meropenem, zosyn

Peak incidence of bronchiolitis

6 months

PMN incidence increases w age?

true

tx for CAP?

Azythromycin