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42 Cards in this Set
- Front
- Back
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Cyclosporine
Mechanism |
Calcineurin inhibitor
Binds cyclophilin Blocks T cell activation by preventing IL-2 transcription |
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Cyclosporine
Use |
Transplant rejection prophylaxis
Psoriasis Rheumatoid arthritis |
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Cyclosporine
Toxicity |
NEPHROTOXICITY
HTN Hyperlipidemia Hyperglycemia Tremor Hirsutism Gingival hyperplasia |
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Tacrolimus and Pimecrolimus
Mechanism |
Calcineurin inhiitor
Binds FK506 binding protein (FKBP) Blocks T cell activation by preventing IL-2 transcription |
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Tacrolimus and Pimecrolimus
Use |
Transplant rejection prophylaxis
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Tacrolimus and Pimecrolimus
Toxicity |
NEPHROTOXICITY and same as cyclosporine.
Increase risk of diabetes and neurotoxicity No gingival hyperplasia or hrsutism |
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Sirolimus (Rapamycin)
Mechanism |
mTOR inhibitor
Binds FKBP Blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction |
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Sirolimus (Rapamycin)
Use |
Kidney transplant rejection prophylaxis
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Sirolimus (Rapamycin)
Toxicity |
Anemia
Thrombocytopenia Leukopenia Insulin resistance Hyperlipidemia NON-NEPHROTOXICITY Extra facts: Synergistic with cyclosporine |
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Basiliximab
Mechanism |
Monoclonal antibody
Block IL-2R |
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Basiliximab
Use |
Kidney transplant rejection prophylaxis
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Basiliximab
Toxicity |
Edema
HTN Tremor |
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Azathioprine
Mechanism |
Antimetabolite precursor of 6-mercaptopurine (6-MP)
Inhibits lymphocyte proliferation by blocking nucleotide synthesis |
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Azathioprine
Use |
Transplant rejection prophylaxis
Rheumatoid arthritis Crohn disease Glomerulonephritis Lupus nephritis |
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Azathioprine
Toxicity |
Leukopenia
Anemia Thrombocytopenia 6-MP degraded by xanthine oxidase -> Toxicity increase by allopurinol |
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Glucocorticoids
Mechanism |
Inhibits NF-KappaB
Suppress both B and T cell function by decreasing transcription of many cytokines |
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Glucocorticoids
Use |
Transplant rejection prophylaxis (immune suppression)
inflmmation and more |
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Glucocorticoids
Toxicity |
Hyperglycemia
Osteoporosis Central Obesity Muscle breakdown Psychosis Acne HTN Cataracts Peptic ulcers (Iatrogenic Cushing syndrome) |
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Daclizumab
Mechanism |
Binds to CD25 in activated T cells blocking IL-2 signal
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Mycophenolate
Mechanism |
Inhibits IMP-dehydrogenase
- Prevents synthesis of guanine - Prevents rapid proliferation of B and T cells |
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Mycophenolate
Use Toxicity |
Use in transplant pts
Off-label for lupus nephritis Increase risk in lymphoma |
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Muromonab
Mechanism |
Binds to CD3 in T cells -> Transplants
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What is the use of Epoetin alfa (erythropoietin)
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Anemias, especially in renal failure
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What is the use of thrombopoietin
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Thrombocytopenia
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What is the use of Oprelvekin (Inerleukin-11)
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Thrombocytopenia
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What is the use of Filgrstim (Granulocyte colony-stimulating factor)
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IL-3
Recovery of bone marrow |
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What is the use of Sargramostim (Granulocyte-mmacrophage colony-stimulating factor)
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IL-3
Recovery of bone marrow |
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What is the use of Aldesleukin (IL-2)
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Renal cell carcinoma
Metastatic Melanoma |
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What is the use of IFN-alpha
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Chronic hepatitis B and C
Kaposi sarcoma Hairy cell leukemia Condyloma acuminatum Renal cell carcinoma Malignant melanoma |
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What is the use of IFN-Beta
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Multiple sclerosis
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What is the use of IFN-gamma
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Chronic granulomatous disease
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Alemtuzumab
Target Clinical Use |
CD52
CLL |
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Bevacizumab
Target Clinical Use |
VEGF
Colorectal cancer Renal cell carcinoma |
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Cetuximab
Target Clinical Use |
EGFR
Stage IV colorectal cancer Head and neck cancer |
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Rituximab
Target Clinical Use |
CD20
B-Cell non-Hodgkin lymphoma Rheumatoid arthritis (with MTX) ITP |
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Trastuzumab
Target Clinical Use |
HER2/neu
Breast cancer Gastric cancer |
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Infliximab, adalimumab
Target Clinical Use |
TNF-alpha
IBD Rheumatoid arthritis Ankylosing spondylitis Psoriasis |
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Natalizumab
Target Clinical Use |
Glycoprotein IIb/IIIa
Anti-platelet agent for prevention of ischemic complications in pts undergoing percutaneous coronary intervention |
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Denosumab
Target Clinical Use |
RANKL
Osteoporosis: Inhibits osteoclast maturation (mimics osteoprotegrin) |
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Digoxin immune Fab
Target Clinical Use |
Digoxin
Antidote for digoxin toxicity |
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Omalizumab
Target Clinical Use |
IgE
Allergic asthma: Prevents IgE binding to FcεRI |
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Palivizumab
Target Clinical Use |
RSV F protein
RSV prophylaxis for high-risk infants |
