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113 Cards in this Set
- Front
- Back
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Cytokine Rx: RCC, Metastatic Melanoma
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Aldesleukin (IL2)
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Cytokine Rx: Anemias (esp in renal failure)
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Erythropoietin (epoietin)
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Cytokine Rx: Recovery of bone Marrow
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Filgastrim (Granulocyte Colony Stimulating Factor)
Sargramostim (granulocyte-macrophage colony stimulating factor) |
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Cytokine Rx: Hep B/C, Kaposi, Leukemia, Malignant Malanoma
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a-interferon
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Cytokine Rx: Multiple Sclerosis
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b-interferon
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Cytokine Rx: Chronic granulomatous disease
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y-interferon
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Cytokine Rx: Thrombocytopenia
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oprelvekin (IL11)
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Cytokine Rx: Thrombocytopenia
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Thrombopoietin
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-afil
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erectile dysfunction
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-ane
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inhalation general anesthetis
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-azepam
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benzo
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-azine
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phenothiazine (neuroleptic, antiemetic)
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-azole
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antifungal
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-barbital
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barbiturate
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-caine
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local anesthetic
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-cillin
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penicillin
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-cycline
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antibiotic, protein synthesis inhibitor
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-etine
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SSRI
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-ipramine
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TCA
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-navir
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protease inhibitor
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-olol
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b-blocker
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-operidol
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butyrophenone (neuroleptic)
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-oxin
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cardiac glycoside (inotropic agent)
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-phylline
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methylxanthine
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-pril
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ACE inhibitor
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-terol
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b-agonist
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-tidine
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H2-antagonist
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-triptan
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5-HT(1A) agonists (migraine use)
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-tryptiline
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TCA
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-tropin
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pituitary hormone
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-zosine
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a1-antagonists
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Resistance Mechanism for penicillins/cephs
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b-lactamase cleavage, or mutation/alteration of PBP (MRSA and resistant S. pneumos)
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Resistance Mechanism for Aminoglycosides
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(A) Acetylation modification (or adenylation or phosphorylation)
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Resistance Mechanism for Vancomycin
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D-ala --> D-lac
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Resistance Mechanism for Chloramphenicol
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Acetylation modification
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Resistance Mechanism for Mecrolides
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(M) Methylation
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Resistance Mechanism for Tetracyclins
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(T) Transport out of the cell of decreased upTake
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Resistance Mechanism for Sulfonamides
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Altered Enzyme (bacterial dihydropteroate synthetase)
also: decreased uptake, or increased PABA synthesis |
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Resistance Mechanism for Quinolones
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Altered Gyrase (or reduced uptake)
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Antimicrobial prophylaxis: Meningococcal infection
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rifampin (or minocycline)
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Antimicrobial prophylaxis: Gonorrhea
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Ceftriaxone
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Antimicrobial prophylaxis: syphilis
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Benzathine Pen G, amoxicillin in delivery
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Antimicrobial prophylaxis:History of recurrent UTIs
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TMP-SMX
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Pneumocystis jiroveci
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TMP-SMX or aerosolized pentamidine if sulfa allergic
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Antimicrobial prophylaxis: endocarditis with surgical and dental procedures
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penicillins
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Mechanism of action: Pens, aztreonam, cephs
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block cell wall synth by inhibiting peptidoglycan cross-linking
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Mechanism of action: bacitracin, vancomycin
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Block peptidoglycan synth
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Mechanism of action: polymyxins
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disrupt cell membranes
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Mechanism of action: sulfonamides, trimethoprim
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block nucleoide synthesis
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mechanism of action: Quinolones
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blocks DNA topoisomerase II
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mechanism of action: rifampin
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blocks mRNA synthesis
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mechanism of action: chloramphenicol, macrolides, clindamycin, streptogramins (-quinupristin and dalfopristin), linezolids
be specific for macrolides, chloramphenicol, and clindamycin |
Block protein synthesis at 50S
macrolides: block translocation chloramphenicol: peptidyltransferase inhibition clindamycin: peptide bond formation |
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Mechanism of action: aminoglycosides and tetracyclins (specifics for each)
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block protein synthesis at 30s
aminoglycosides: misreading and complex formation blockage tetracyclins: prevent attachment of aminoacyl-tRNA |
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antacids, milk, iron-chelators
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inhibit tetracyclines
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First Gen Cephs
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Cefadroxil
Cefazolin "CePHs" |
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2nd Gen Cephs
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PUMA (Cefp, Cefu, Cefm, Cefa)
Loracarbef Cefotetan Cefonicid (nine letters) Cefoxitin (nine letters |
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3rd gen Cephs
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TIDE (Ceft, Cefi, Cefd, Cefe)
Moxalactam Cefoparazone (ten letters) Ceotaxime (ten letters) |
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pseudomonas cephs
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ceftazidime (3rd gen)
Cefepime (4th gen) |
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gonorrhea ceph
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ceftriaxone
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1st gen cephs used against
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PEcK - Proteus, E. coli, Klebsiella
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2nd Gen Cephs used against
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HEN PEcKS
Haemophilus, Enterobacter, Neisseria, Proteus, E. coli, Klebsiella, Serratia |
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Linozolid mechanism
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50 S and inhibits initiation complex (ribosomes and initiator tRNA)
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Aminoglycosides mechanism
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30s and inhibits initiation complex and causes misreading (FA also says it blocks the A-site)
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Chloramphenicol mechanism
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50S and blocks peptidyle transferase
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Erythro Mechanism
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50s and translocation step
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Clindamycin Mechanism
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50s and blocks peptide bond formation (and FA also says translocation step)
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Lincomycin mechanism
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50s and translocation step
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Tetracycline mechanism
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30s and blocks A-site
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MRSA treatment
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vancomycin
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VRE (vancamycin resistant) treatment
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linezolid and streptogramins
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quinupristin and dalfopristin (what drug category? used for what?)
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streptogramins, used for Vancomycin resistant bugs
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Amantadine pnemonics
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A man to dine takes off his coat.
Amantadine blocks influenzA (A) rubellA, and causes problems with your cerebellA) |
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Sulfadrugs
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Celecoxib, furosemide, probenicid, thiazides, tmp-SMX, sulfasalazine, sulfonylureas
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SE of HMGCoA reductase
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rhabdomyolysis
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SE niacin
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flushing, decreased by aspirin
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SE Bile Acid Resins
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dec. absorption of FSVs, contraindicated in patients with gallstones (increased new bile synth)
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SE fibrates
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myositis, increased LFTs
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SE cholesterol absorption blockers (ezetimibe)
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LFT increase (rare)
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Insulin SE/Tox
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hypoglycemia, hypersensitivity rxns, hypokalemia
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Sulfonylureas SE/Tox
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disulfiram effect (first gen)
(2nd gen) hyoglycemia |
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Biguanides SE/Tox
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LACTIC ACIDOOSIS
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Glitazone SE/Tox
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HEPATOTOXICITY, Weight gain, edema, CV toxicity
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What kind of drug is this: tolbutamide
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(1st gen) sulfonylurea (close K channels, increase insulin secretion)
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What kind of drug is this: chlorpropramide
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(1st gen) sulfonylurea (close K channels, increase insulin secretion)
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What kind of drug is this: Glyburide
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(2nd gen) sulfonylurea (close K channels, increase insulin secretion)
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What kind of drug is this: glimepiride
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(2nd gen) sulfonylurea (close K channels, increase insulin secretion)
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What kind of drug is this: glipizide
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(2nd gen) sulfonylurea (close K channels, increase insulin secretion)
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What kind of drug is this: metformin
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biguanide
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What kind of drug is this: pioglitazone
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glitazone (binds PPAR-y, causes increased insulin sensitivity peripherally)
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What kind of drug is this: rosiglitazone
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glitazone (binds PPAR-y, causes increased insulin sensitivity peripherally)
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What kind of drug is this: Miglitol
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a-glucoside inhibitor
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what kind of drug is this: acarbose
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a-glucoside inhibitor
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What kind of drug is this: repaglitinide
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meglitinide (binds potassium channels, like sulfonylureas, and increases insulin secretion.
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What kind of drug is this: nateglinide
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meglitinide (binds potassium channels, like sulfonylureas, and increases insulin secretion.
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What kind of drug is this: sitagliptin
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DPP-4 inhibitor: inhibit DPP4 breakdown of GLP1s
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What kind of drug is this: vildagliptin
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DPP-4 inhibitor: inhibit DPP4 breakdown of GLP1s
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What kind of drug is this: saxagliptin
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DPP-4 inhibitor: inhibit DPP4 breakdown of GLP1s
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What kind of drug is this: exanatide
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GLP1: increased insulin secretion and decreases glucagon secretoin
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What kind of drug is this: liraglutide
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GLP1: increased insulin secretion and decreases glucagon secretoin
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What kind of drug is this: diazoxide
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anti-meglitinide/sulfonyureas (potentiates potassium channels in b-cells and decreases insulin secretion)
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H. Pylori teatment
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Triple therapy: Metronidazole, Amoxicillin (or Tetracyclin), Bismuth
(MAke Tummy Better) Quad therapy: PPI added to Triple Therapy (Please MAke Tummy Better) |
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What kind of drug is this: prochlorpromazine
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antiemetic that blocks D2 receptors in the area postrema
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what kind of drug is this: metoclopramide
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antiemetic that blocks D2 receptors in the area postrema
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Target of methotrexate
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Nucleoside synthesis
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target of 5fu
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nucleoside synthesis
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target of 6mp
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nucleoside synthesis
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target of alkylating agents
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DNA (cross linking)
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target of cisplatin
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DNA (cross linking)
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target of Anthracyclines
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DNA (intercalating agents)
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target of etoposide
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DNA (topoisomerase II inhibitor)
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target of palitaxil
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cell division: inhibits microtubule disassembly
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target of vinca alkaloids
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cell division: inhibits microtubule formation
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difference between etanercept infliximab and adalimumab
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etanercept is a decoy TNFa receptor
infliximab is a TNFa antibody adalimumab is an antibody against TNFa receptors |
