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680 Cards in this Set
- Front
- Back
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What is the wavelength of CO2 laser?
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10,600 nm
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What are the classic oral manifestations of Darier's disease?
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Cobblestoning of buccal mucosa.
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What is the chemical name for "padimate o"?
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Octyl-dimetnyl-PABA
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What is the anesthetic most commonly associated with methemoglobinemia in children?
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Prilocaine
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What is the predominant retinoid receptor aganoist expressed in the epidermis?
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RAR-gamma; RXR-alpha
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What os the most effective UVA chemical sunscreen?
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Avobenzone (trade name=Parsol 1789); dibenzoylmethane derivative that breaks down quickly so photostabilizers like Mexoryl are added to it
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Lasers typically used for green tattoos?
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Alexandrite (755 nm) and Ruby (694 nm)
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What os the eye abnormality associated witrh Ehlers-Danlos Syndrome?
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Keratconus
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What is the drug of choice for gram negative folliculitis?
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Isotretinoin
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What is the metabolic abnomrlaity associated with HIV-related lipodystrophy?
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Hypertriglyceridemia
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Calcipotriene-induced improvement in psoriasis is associated with increased levels of which cytokine in lesions?
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IL-10
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What is the antigen for chronic bullous disease of childhood?
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97 Kda LAD-1 (Component of BPAg2)
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What is the antigenic chemical in baby wipes?
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Benzalkonium chloride
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What is the active ingredient in Burrow's solution?
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Aluminum acetate
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What is the nail abnormality associated with Argyria?
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Blue lunulae ("blue moon")
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What is the complication associated with systemic interferon-alpha treatment for hemangiomas?
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Spastic diplegia and thyroid dysfunction
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List the common source of each: (1) Cyanoacrylate, (2) Methyl methacrylate, (3) Toluene sulfonamide formaldehyde resin, (4) Ammonium thioglycolate, (5) Benzalkonium chloride?
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(1) Cyanoacrylate: Adhesives used with artifical nails; (2) Methyl methacrylate: Artificial nails; (3) Toluene sulfonamide formaldehyde resin: Nail polish; (4) Ammonium thioglycolate: Permanent wave solutions; (6) Benzalkonium chloride: Baby wipes
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What is the ANA pattern most closely associated with systemic sclerosis?
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Nucelolar
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What medication is associated with dysgeusia (distorted/decreased sense of taste)?
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Fluconazole ("Mushrooms have no real taste!")
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What is the genetic condition associated with Elastosis Perforans Serpiginosa (chronic papular keratotic eruption in arciform shape on sides of the nape of the neck; grouped in horseshoe/serpiginous arrangement)?
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Down's Syndrome (1% of Down's patients; lesions are usually more extensive and persistent)
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Why is ganciclovir more effective than acyclovir for CMV?
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Prefential binding to the CMV-encoded phosphotransferase
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Histiologic finding in Acute Hemorrhagic Edema of Infancy (Finkelstein's Disease; associated with preceding URI sxs/antbx; less than 2 yo; cockade; lasts 2-3 weeks)?
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Leukocytoclastic vasculitis; lacks IgA on DIF
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What are the locations of Keratins 1 and 10?
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Spinous layer
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What is the HLA-type associated with HSV-induced Erythema Multiforme?
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HLA-B15
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Angiocentric NK/T-cell lymphoma in children may present asÉ
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Hydroa vacciniforme (chronic photodermatosis; cropped vesicles on ears, nose, cheeks, extensor arms/hands; +stinging; heal with smallpox-like scar; subset of pts have EBV infection; may procede lymphoma by up to a decade)
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What is the characteristic histiologic finding in Follicular Degenration Syndrome (Hot Comb Alopecia)?
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Premature desquamation of the inner root sheath epithelium
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By what mechanism of action does CellCept work?
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Aka, mycophenolate mofetil; inhibits Type II inosine monophosphate dehydrogenase, which decreases the denovo pathway of guanine synthesis
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Things stained with Massin trichrome includeÉ
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Collagen - Bluegreen; Muscle/Nerve - Red
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What is the organism associated with Malakoplakia (rare granuloma in immunosuppressed pts; characterized by inguinal yellowish-red papules/draining sinuses; treat with Cipro)?
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Pts have defective intracellular digestion of bacteria once they have been phagocytizedÉ1) S. aureus, 2) P. aeruginosa, 3) E. coli
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What is the best test for aseptic necrosis of the femoral head?
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MRI
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What is the cause of tinea nigra?
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Exophiala werneckii
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What is the agent associated with Herpangina?
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Coxsackie virus
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What is the skin pigment abnormality associated with impiramine?
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Photodistributed hyperpigmentation
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What is the treatment of chlamydia during pregnancy?
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Erthryomycin base
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What gene is mutated in Marfan's syndrome?
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FBN1 = Fibrillin
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Which disease is associated with poliosis?
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Poliosis aka as leukotrichia = white hair; vitiligo
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Most common cancers associated with Cowden syndrome (PTEN tumor suppressor gene; autosomal-dominant disease associated with trichilemmomas occuring as multiple facial lesions)?
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1. Thyroid, 2. Breast. 3. Endometrial. Malignancy develops in 40% of Cowden's syndrome patients.
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Most common location of Becker's nevus?
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Shoulder
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What is the cyst that most commonly presents as an asymptomatic nodule over the suprasternal notch?
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Bronchogenic cyst
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Most common form of oculocutaneous albinism in African-Americans?
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OCA Type II
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Which congenital disease is associated with an increased risk of latex allergy?
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Spina bifida (presumably from increased contact in neonatal period?)
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Which autoantibody is most commonly associated with Neonatal Lupus?
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Anti-Rho (SSA); Anti-La (SSB) and Anti-V1RNP are also associated but to a lesser extent
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Which ocular abnormality is associated with Cockayne Syndrome?
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Salt and Pepper Retinal Pigmentation
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Which plant family is most frequently implicated in causing phytophotodermatitis?
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Umbelliferae; includes cumin, parsley, carrot, coriander/cilantro, dill, caraway, fennel, parsnip, celery, Queen Anne's Lace. has the same root as the word "umbrella" which you need in order to avoid the sun!!!
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What is the inheritance pattern and gene for Bullous Congenital Ichthosiform Erythroderma (BCIE)?
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AD; Keratons 1, 10
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What is the gene and inheritance pattern of Lamellar Ichthyosis?
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AR; Gene=TGM1=Transglutaminase 1 (absence leads to defective attachment and cross-linking of cell envelope proteins)
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Inheritance pattern of Congenital Ichthyosiform Erythroderma (CIE)
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AR
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What are the eye findings associated with X-Linked Ichthyosis?
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Comma-shaped corneal opacities at the level of Descemet's Membrane; may also be detected in female carriers
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What is the X-ray bone abnormality seen in Trichorhinophalangeal Syndrome?
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Cone-shaped epiphysis of the middle phalanges of the hands
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What is the X-ray bone abnormalities seen in Nail-Patella Syndrome?
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1. Small patella; 2. Bony spines arising from posterior aspect of iliac bones.
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What is the vascular tumor associated with Kasabach-Merrit Syndrome?
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Kaposiform Hemangioendothelioma
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What is the eponym for Incontinentia Pigmenti?
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Bloch-Sulzberger Syndrome
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What gene is mutated in Incontinentia Pigmenti?
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NEMO (NFKB essential modulator; loss leads to uncontrolled apoptosis)
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What are the local anesthetics with the LONGEST duration of action?
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Bupivacaine (Marcaine) and Etidocaine (DuraNest)
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What are the clinical features of Sneddon's Syndrome?
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positive anti-phospholipid antibodies (40%); cutaneous thrombotic lesions; livedo reticularis; cerebrovascular disease; subset of lupus
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What is the antibody in dermatomyositis that is associated with increased risk of pulmonary disease?
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Anti-Jo 1 antibody
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What antibody is associated with relapsing polychondritis?
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IgG against Type II collagen
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What is RF?
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IgM against IgG
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What is the significance of the "peripheral" ANA pattern?
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Reflects high titer against anti-DNA antibody; marker of active systemic disease
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What is the classic causative associations for scleroderma?
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1. URI (typically Streptococcal), 2. Diabetes (late onset, insulin-dependent DM)
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What are the normal primary dermal mucins?
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Sulfated Acid Mucopolysaccahrides: 1) Condroitin sulfate; 2) Heparin sulfate
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Which antibody is most specific for CREST syndrome?
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Anti-centromere antibody (positive in 50-90% of cases; only positive in 2-10% of patients with progressive systemic sclerosis)
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What are the two types of systemic scleroderma?
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1) CREST Syndrome, 2) Progressive Systemic Sclerosis
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What are the clinical features of Perr-Romberg Syndrome?
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Variant of linear scleroderma with progressive hemi-facial atrophy; epilepsy; exopthalmos; alopecia; +/- spina bifida with lower extremity involvement
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What is the X-ray finding in linear scleroderma?
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Melorheostosis (dense linear cortical hyperostosis)
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What is the blood supply of a paramedia forehead flap?
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Supratrochlear artery
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What is the active ingredient of the Brown Recluse Spider (Loxoscles reclusa)?
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Sphingomyelinase D2 (a phospholipase)
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What is the wavelength and main clinical use of the KTP (Potassium-titanyl-Phosphate) laser?
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532 nm; vascular lesions and epidermal pigmentation (Kills Telangiectasias Positively!)
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What are the classic skin lesions in Louis-Barr Syndrome?
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Mucocutaneous telangiectasias (other name is Ataxia-Telangiectasia Syndrome)
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Which virus is ss-DNA?
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Parvo virus
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What is the pigment abnormality associated with chlorpromazine?
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Photoinduced, photodistributed, blue-gray hyperpigmentation
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What is the bone X-ray abnormality seen in Conradi-Hunermann Syndrome?
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Stippled epiphysis of long bones
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DIF deposition pattern in dermatitis herpetiformis
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Granular IgA at the dermal papillary tips
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Type of protein associated with lichen amyloidosis
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Keratin protein
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Type of protein associated with primary systemic amyloidosis
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Monoclonal light chain protein
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Type of protein associated with macular amyloidosis
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Keratin protein
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Characteristic cell type associated with a subcutaneous T-cell lymphoma
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Bean bag cells
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Disease associated with anti-epiligrin (laminin 5) antibodies
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Cicatricial pemphigoid
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Autoantigens associated with bullous systemic lupus
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#NAME?
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Antigen associated with IgA pemphigus of the subcorneal pustular dermatosis type
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desmocollin I
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Antibody associated with lupus nephritis
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Anti-double stranded DNA
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Tumor is classic for Brooks spiegler syndrome
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Trichoepithelioma's and cylindromas
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Gene in Ehlers-Danlos or dermatosparaxis type
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Pro collagen one N terminal peptidase
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Enzyme defects in Refsum's syndrome
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phytanic acid oxidase
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Follicular tumor associated with Bannayan-Riley-Ruvalcaba syndrome
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Trichilemmoma
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Gene in Ehlers-Danlos vascular type
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Collagen 3a1
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Etiologic agent of a oroya fever and verruga peruana
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Bartonella bacilliformis
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Familial neoplastic diseases associated with mutations in PTEN
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Cowden's, lhermitte-duclos disease, Bannayan zona, Proteus
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Chemical antigen found in parsnip
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Furocoumarin
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Type of toxin produced by the sac spider chiracanthum
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Lipase
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Etiologic agent and vector are for the plague
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yersinia pestis, oriental rat flea (xenopsylla cheopis)
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Follicular tumors associated with a Rasmussen's syndrome
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Multiple trichoepitheliomas, cylindromas, milia
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Agents and vector for or oroya fever and verruga peruana
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Agent. Bartonella baciliformis, vector lutzomyia verrucurum
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Microscopic appearance of sporotrichosis
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Cigar-shaped or oval yeast
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Microscopic appearance of paracoccidioidomycosis
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mariner's wheel
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Microscopic appearance of coccidioidomycosis
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Large spherule with endospores
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Microscopic appearance in blastomycosis
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Thickwalled, spherical yeast cells with broad based buds
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Epithelial lining associated with epidermoid cysts
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Simple stratified squamous with keratinization through a granular layer
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Epithelial lining associated with trichilemmal cysts
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Palisaded squamous with an absent granular layer
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Endemic Typhus: Agent and vector
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Rickettsia typhi, vector: rat flea versus cat flea
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Agent plus vector in the American trypanosomiasis
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Chagas disease: trypanosoma Cruz E.; vector Reduvid bug
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Type of cellular infiltrate in kimura's disease
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Equals angiolymphoid hyperplasia with eosinophilia: Eosinophils
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Histologic features of the cyst wall in steatocystoma multiplex
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Sebaceous lobules within the cyst wall
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Pigmentary change associated with intravenous 5-flurouracil
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Serpentine supra-venous hyperpigmentation
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Sensitizing antigen associated with cement
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chromates
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Allergen associated with leather exposure
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chromates use as tanning agents
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Gene mutation for ichthyosis vulgaris
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Filaggrin
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Antigen associated with sensitization to coal tar hair dye
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Para-phenylenediamine
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sesquiterpene lactone mixed screens for a sensitivity to what?
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compositae plants
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Antigen associated with wool wax alcohol
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lanolin alcohol
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Gene and defect associated with dyskeratosis congenita
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dyskerin gene (functions in the synthesis of ribosomal and rRNA precursors)
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Genus mutations associated with pilomatricoma
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Beta catenin
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Gene for lamellar ichthyosis
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transglutaminase
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The gene for Birt-Hogg-Dube
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BHD, folliculin
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Gene mutated in white sponge nevus
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Keratin 4 and keratin 13
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Gene mutated in incontinentia pigmenti
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NEMO
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Epithelial lining associated with milium
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Simple stratified squamous epithelium
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Immunophenotype of a dermatofibrosarcoma protuberans
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CD34 positive, factor XIIIa negative, S100 negative
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What type or tumor is a Bednar tumor
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A pigmented form of a dermatofibrosarcoma protuberans
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Microscopic hair abnormality in loose anagen syndrome
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Ruffled cuticle
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Disease associated with Michaelis Gutman bodies
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Malacoplakia (calcified concentrically laminated intracytoplasmic bodies within foamy eosinophilic hausmenann macrophages
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Disease associated Verocay bodies
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Schwannoma
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Cell type associated with Weibel-Palade bodies
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Endothelial cells
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Disease associate with mulberry cells
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hibernoma
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Histologic feature that can help distinguish lichenoid drug from lichen planus
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Parakeratosis and eosinophils
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Enzyme defect in congenital erythropoietic porphyria
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uroporphyrinogen 3 cosynthase
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Bone x-ray abnormality in linear morphea
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melorheostoses:
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HPV type associated with deep plantar and palmar warts
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HPV 1
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Wavelength and clinical uses of the ng-yag laser
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1064 nm: Dermal pigmentation, blue, black tattoos; nevus of oata and Ito, hair removal in dark people
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Wavelength of q. switched Ruby laser
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694 nm
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Disease associated with Cowdry type A bodies
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Herpes simplex, or varicella-zoster
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Stain for Michaelis-Gutmann bodies
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Von Kossa
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Organism that causes oral hairy leukoplakia
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Epstein-Barr virus
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organism in the cause is black piedra
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piedra hortae
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Antigen in fogo selvagem (Brazilian pemphigus)
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desmoglein 1
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Nerve associated with Frey's syndrome
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Auricular temporal nerve (used to Torrey sweating after a parotid surgery)
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HPV type in giant condyloma of Buschke and Loewenstein
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HPV 6
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Medication associated with ultraviolet recall
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Methotrexate
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Radiographic bone abnormality for focal dermal hypoplasia
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Osteopathic striata
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Radiographic bone abnormality for basal cell nevus syndrome
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Bifid ribs
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Radiographic bone abnormality for a linear morphea
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melorheostosis
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Radiographic bone abnormality for Buschke-Ollendorf syndrome
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osteopoikilosis
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Gray roughened bone abnormality for Maffucci syndrome
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Enchondromas
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Antigen in pemphigus vegetans
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Desmoglein 3
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T. H. Pole associated with lepromatous leprosy
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Th two
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T. H. Pole associated with tuberculoid leprosy
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Th one
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Syndrome associated with glomeruloid hemangiomas
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POEMS syndrome
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Disease associated with Michaelis-Gutmann bodies
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Malacoplakia
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Enzyme defect in porphyria cutanea tarda
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Uroporphyrinogen decarboxylase
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Stains for amyloid
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Congo red (red with green birefringence under polarized light); Crystal violet
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Stains for acid fast bacilli
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Fite stain (red bacilli)
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Antigen and pemphigoid gestationis (herpes gestationis)
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Bullous pemphigoid antigen 2, type 17 collagen
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Tattoo pigment that can undergo immediate darkening by the q. switched laser
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Red
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Wavelength of the pulse dye laser
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577-585 nm
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Autoantigen associated with relapsing polychondritis
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Type II collagen
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Antibody found in dermatitis herpetiformis
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IgA against tissue transglutaminase, IgA deposition in a granular pattern in the dermal papilla
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Antigen for pemphigus foliaceous
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Desmoglein one
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Antigen in pemphigus vulgaris
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Desmoglein 3
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Agents associated with hand foot and mouth disease
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Coxsackie virus A16
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Nucleic acid type and number of strands in of varicella-zoster virus
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Double-stranded DNA
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Agents associated with necrolytic acral erythema
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Hepatitis C
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Virus is associated with pityriasis rosea
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Human herpes virus 6 and 7
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HPV type associated of the butcher's warts
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HPV 7
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Chemical peel agent that can be nephrotoxic
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Phenol
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Mode of transmission for cutaneous Larva migrans
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soil contents
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Wavelength of neodidium-YAG
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1064 nm
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Wavelength of frequency doubled Nd-Yag laser
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532 nm
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I structure at the greatest risk of injury from a pulse dye laser
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Retina
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Bone x-ray abnormalities seen and focal dermal hypoplasia
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Osteopathic striata
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X-ray bone abnormality seen in Buschke-Ollendorf syndrome
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Osteopoikilosis (round to oval opacities within long bones and hand and foot bones
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X-ray finding in Maffucci syndrome
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Enchondromas
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Most common location for Merkel cell carcinoma
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Head and neck (50%)
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Characteristic skin lesion in Osler-Weber-Rendu syndrome
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She lens ectasias (hereditary hemorrhagic telangiectasia)
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Hair abnormality seen in the Bjornstads syndrome
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pili torti, and sometimes alopecia
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Eye abnormality associated with Marfan's syndrome
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Ectopia lentis (upward)
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The enzyme defect in erythropoietic protoporphyria
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ferrochelatase
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Drug classically associated with elastosis perforans serpiginousa
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Penicillamine
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Most common malignancy associated with acquired ichthyosis
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Hodgkin's lymphoma
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Ligand for CD2
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LFA-3
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Ligand for ICAM-1
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LFA-1 (CD11a-CD18)
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Ligand for CD28
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B7 (CD28 mostly helper Tcells, B7 mostly Bcells or antigen-presenting cells.
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Ligand for MHC-I (other than TcR)
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CD8
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Ligand for MHC-II
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CD4
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Neoplasm most likely associated with bazex syndrome
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Esophageal Cancer
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name the disease associated with Lisch Nodules
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NF-1
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name the disease associated with Retinal Pigmentation
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Anti-malarials
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name the disease associated with Angioid Streaks
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Pseudoxanthoma elasticum (PXE)
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name the disease associated with Blue sclerae
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osteogenesis imperfecta
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name the disease associated with Anterior subcapsular cataracts
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Atopic Dermatitis
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name the disease associated with Posterior subcpsular cataracts
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NF-2
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HLA-types associated with Guttate Psoriasis
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HLA -Cw6 and HLA -B17
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Disease associated with eruptive syringomas
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Nicolau-Bulus Syndrome
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Keratins expressed in hyperproliferative epidermis
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Keratins 6 + 16
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Neoplasm associated with highest risk of Trousseau's Syndrome (migratory thrombophlebitis)
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Pancreatic cancer
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Skin findings in Phenylketonuria (PKU)
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Pigmentary dilution of skin and hair. Eczematous dermatitis
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Transection of the supratrochlear nerve will cause
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Numbness of the central forehead
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radiologic brain abnormality seen in Lipoid protenosis
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Bilateral bean-shaped calcification of the hippocampus
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Bone abnormalities associated with conradi-hunermann syndrome
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Pathologic fractures
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Location in skin of type IV collagen
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Lamina Densa -- main component of the lamina densa
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Ocular abnormality associated with Ataxia Telangiectasia
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Conjunctival Telangiectasias
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Cancer most commonly associated with the non-inheritedor acquired form of Bazex Syndrome (Acrokeratosis paraneoplastica)
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Squamous cell carcinoma of the upper respiratory tract or GI tract
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Anesthetics in EMLA
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Lidocaine + prilocaine
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Most common malignancy associated with acquired C1-esterase inhibitor deficiency
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Lymphoma
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Most common organism in Tinea corporis gladiatorum
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Trichophyton Tonsurans
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Serum test that can be used to distinguish between acquired and hereditary angioedema
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C1 levels. Hereditary has a normal C1. Acquired has a low C1
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Immunoglobin that is increased in Th2 immune responses
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IgE
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Basis for cutaneous ulcers associated with interferon-beta therapy
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Thrombosis
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nail abnormality assocaited with hepatolenticular degeneration (Wilson's dz)
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Blue Lunulae
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Causes of koilonychia
|
Fe- deficiency, Plummer-Vinson syndrome, Hemochromatosis, Occasionally in chronic liver disease
|
|
|
Classic eye findings in Ehlers-Danlos Syndrome
|
keratoconus - conical collagen conturing deformity of the cornea
|
|
|
Color of pigmentary change in hemosiderin
|
Red brown
|
|
|
Color of pigmentary change in Clofazimine
|
Red brown
|
|
|
Color of pigmentary change in Minocycline
|
Blue
|
|
|
Color of pigmentary change in Gold
|
Lilac
|
|
|
Color of pigmentary change in Silver
|
Slate gray
|
|
|
Subcellular component in homogenous ANA
|
native DNA, RNP, Histones
|
|
|
mechanism of action for cyclophosphamide
|
derivative of nitrogen mustard that cross-links DNA
|
|
|
Type of porphyria with normal stool porphyrias
|
acute intermittent Porphyria ("Ain't In Poop")
|
|
|
Epidermal differentiation marker upregulated by tazorac in psoriasis lesions
|
Filaggrin
|
|
|
Periplakin MW
|
190kd
|
|
|
Desmoplakin MW
|
250kd
|
|
|
Yellow spectrum lasers and wavelengths
|
Flash lamp pumped yellow dye (long pulsed) 585nm. Copper Vapor (rapid-pulsed) 578nm. Krypton laser 560nm.
|
|
|
Wavelength of the gallium-aluminum arsenide diode laser
|
805-810nm
|
|
|
Organism that causes keratomycosis (fungal infection at the cornea)
|
Fusarium solanae
|
|
|
Name the primary follicular tumor for Birt-Hogg-Dube
|
Trichodiscoma
|
|
|
Name the primary follicular tumor for Rassmussen's Syndrome
|
Trichoepithelioma
|
|
|
Name the primary follicular tumor for Rombo Syndrome
|
Trichoepithelioma
|
|
|
Name the primary follicular tumor for Cowden's
|
trichilemmoma
|
|
|
Name the primary follicular tumor for Bannyan-Riley-Ruvalcaba
|
trichilemmoma
|
|
|
Enzyme deficiency associated with anticonvulsant hypersensitivity syndrome
|
Epoxide hydrolase
|
|
|
Maximum dose of lidocaine for tumescent anesthesia
|
55mg/kg of 0.05-0.1% lidocaine with 1:100000 epinephrine
|
|
|
Xanthine oxidase inhibitor that increases the toxciity of azathioprine
|
Allopurinol. Azathioprine is converted to 6-MP which is then converted to 6-thiouric acid by xanthine oxidase. Allopurinol inhibits xanthine oxidase.
|
|
|
Risk of erythromycin estolate in pregnancy
|
increased risked of acute cholestatic hepatitis
|
|
|
WHO Therapy for newly diagnosed tuberculoid (pauci-bacillary TB)
|
Dapsone 100mg QD, Rifampin 600mh q month x 6 months
|
|
|
WHO therapy for multi-bacillary leprosy
|
Dapsone 100mg QD, Clofazimine 50mg QD, Rifampin 600mg q month, Clofazimine 300mg q month for 2 years. Preferably used until negative skin smears.
|
|
|
Classic Drug associated with acquired ichthyosis
|
Nicotinic acid
|
|
|
Peak Absorption wavelength for porphyrins
|
400-410nm
|
|
|
Antibody associated with homozygous C2 deficiency
|
Anti-Ro (SSA)
|
|
|
Drug a/w DM-Like eruption w/o myositis
|
Hydroxyurea
|
|
|
Gene in EDS, kyphoscoliosis type
|
Lysyl hydroxylase
|
|
|
Clinical Features of Darier-Roussy Syndrome
|
Sarcoid-assoc syndrome w/ subcutaneuous nodules of the trunk and extremeties
|
|
|
Things stained by Toludine Blue
|
Mast Cells--> Metachromatically purple
|
|
|
Organism that causes penicilliosis
|
Penicillium marneffei
|
|
|
Gene for Papillon Lefevre Syndrome
|
Cathepsin C
|
|
|
Agent and Vector for Kala-azar
|
Kala-azar=visceral Leishmaniasis; Leishmania donovani, Vector=Sandfly
|
|
|
HPV types a/w common warts
|
HPV 2,4,27,29
|
|
|
Gene a/w Monilethrix
|
Keratins hHb1 and hHb6
|
|
|
Definitions of Peel depths
|
Very Superficial --> Strat Corneum (Granular Layer); Superficial --> Basal Layer/Upper Papillary dermis; Medium --> Through papillary dermis to upper reticular dermis; Deep --> Mid-reticular dermis
|
|
|
Characteristic histologic fat changes a/w pancreatic panniculitis
|
Ghost-like fat cells w/ calcium granules
|
|
|
Eye abnormalities a/w homocystinuria
|
Ectopia lentis (downward)
|
|
|
Depth and composition of Baker's Peel
|
Deep --> Mid Reticular dermis; Phenol
|
|
|
Inheritance and gene for pachonycia congenita type II
|
AD, Keratin 6b and 17
|
|
|
Inheritance and gene for pachonycia congenita type I
|
AD (some AR variants), Keratin 6a and 16
|
|
|
Eponym for Epidermolytic PPK
|
Vorner's
|
|
|
Inheritance and gene in Epidermolytic Palmplantar keratoderma (EPPK)
|
AD, Keratin 9
|
|
|
Classic hair abnormality in Netherton's
|
Bamboo Hair = Trichorrhexis invaginata. (Can also see Pili Torti)
|
|
|
Disease a/w ichythiosis hystrix
|
Bullous Congenital ichthyosiform erythroderma = porcupine quill-like hyperkeratosis
|
|
|
Disease a/w pigmentary abnormality: Whorled hyperpigmentation
|
Icontinentia pigmenti (Bloch-Sulzburger)
|
|
|
Target for exfoliative toxin A in bullous impetigo
|
Desmoglein I
|
|
|
Etiologic agent in ORF
|
Parapoxvirus
|
|
|
Most common location for a desmoid tumor
|
Abdomen
|
|
|
Allergen to test w if allergy to chrsanthemums is suspected
|
Sesquiterpene Lactone
|
|
|
Cross-reactin chemicals in pts w/ allergy to paraphenylenediamine
|
PABA-containing sunscreens, Ester-type local anesthetics, Topical or systemic Sulfonamides
|
|
|
Skin malignancy a/w the inherited form of Bazex syndrome
|
BCC
|
|
|
Organisms that causes Tinea Nigra
|
Phaeoannellomyces werneckii, (?Horaea werneckii)
|
|
|
HPV types a/w Bowenoid Papulosis
|
HPV 16
|
|
|
Follicular tumor a/w Cowden's Syndrome
|
Trichilemmommas
|
|
|
Gene a/w Epdiermolysis Bullosa Simplex
|
Keratins 5 and 14
|
|
|
Boutanneuse Fever, Agent and Vector
|
Ricketsia conori; Vector = Tick borne
|
|
|
Gene mutation in Oculocutaneous Albinism 2
|
Tyrosinase-related protein 1 gene
|
|
|
Enzyme defect in Fabry's Disease
|
alpha-galactosidase A
|
|
|
Type of toxin produced by the Wolf spider (Lycosidae)
|
Histamine
|
|
|
Microscopic yeast appearance in histoplasmosis
|
Derma macrophages packed with tiny yeast forms
|
|
|
Disease a/w Henderson-Patterson body
|
Molluscum
|
|
|
Disease that shows lobular panniuculitis w vasculitis
|
Erythema Induratum
|
|
|
Disease a/w civatte bodies
|
Lichen Planus
|
|
|
Disease a/w Kamino bodies
|
Spitz Nevi
|
|
|
Classic histologic fat changes a/w post-steroid panniculitis
|
Needle-shaped clefts
|
|
|
Characteristic histologic fat defect a/w subcutaneous fat necrosis of the newborn
|
Needle-shaped clefts
|
|
|
Etiologic agent and vector in Scrub typhus
|
Rickettsia Tsutusgamushi. Vector: Chigger, Trombiculid Scrub typhus Mite, Genus:Leptotrombidium
|
|
|
Diseases transmitted by bedbugs (Cimex Lenticularis)
|
Hepatitis B
|
|
|
Type of toxin produced by the Jumping Spider (Hidippus)
|
Hyaluronidase
|
|
|
Etilogic agen of Glanders disease
|
Burkholderia malleri (Pseudomonas malleri= former name)
|
|
|
Keratin Defect in epidermolytic palmoplantar keratoderma
|
Keratin 9
|
|
|
Gene mutation in Epidermolytic hyperkeratosis (EHK) aka bullous congenital ichthyosiform erythroderma
|
Keratin 1 and 10
|
|
|
Gene mutation in Vohwinkel's
|
Loricrin
|
|
|
Gene mutated in NF2
|
Merlin (aka schwannomin)
|
|
|
Follicular tumors a/w Birt-Hogg-Dube Syndrome
|
Trichodiscomas, Multiple fibrofolliculomas
|
|
|
Etiologic agen in Cat Scratch Disease
|
Bartonella Henslae
|
|
|
Etiolgic agen in Bacillary angiomatosis
|
Bartonella Henslae
|
|
|
Malignancy most commonly a/w Tripe Palm
|
Gastric and Lung CA
|
|
|
Chemical antigen found in Chrsanthemums
|
Sesquiterpene Lactone
|
|
|
Gene a/w Ichthyosis bullosa of Siemens
|
Keratin 2e
|
|
|
Gene and inheritance pattern for alkaptonuria
|
AR, Gene= Homogentistic Acid Oxidase
|
|
|
Mutation a/w Mastocytosis
|
C-Kit
|
|
|
Cowden's Disease Gene mutation
|
PTEN (tumor suppressor gene)
|
|
|
Cancer a/w Birt-Hogg-Dube Syndrome
|
Renal cell carcinoma
|
|
|
Defect in Junctional epidermolysis bullosa w/ Pyloric Atresia
|
alpha-6, beta-4 Integrin
|
|
|
Defect in EB-Simplex Dowling-Mera type
|
Keratins 5 and 14
|
|
|
Location in skin of type IV collagen
|
Lamina Densa -- main component of the lamina densa
|
|
|
HLA associated with late onset, type II psoriasis
|
Cw2
|
|
|
HLA associated with late onset, type I psoriasis
|
Cw6, B57, DR7
|
|
|
Genetic Loci assoc with psoriasis
|
Class I and II MHC, PSORS1 Chromo 6, PSorS2 Chr 17q
|
|
|
Drugs assoc with pustular psoriasis
|
corticosteroid w/d, iodides, Coal Tar, Terbinafine, Minocycline, hydroxychloroquine, acetazolamide, salicylates
|
|
|
Typical dosing regimen of etanercept
|
50 mg SQ BIW for 12 weeks, then 50 to 25 mg q week
|
|
|
Oral changes assoc with pustular psoriasis
|
red, scaly lips; superficial ulcerations of tongue, mouth; geographic, fissured tongue
|
|
|
Rx for chronic strep carriage in psoriasis pt
|
dicloxacillin 250 mg PO QID and Rifampin 600 mg PO Qday for 10 days total
|
|
|
Infliximab (remicade) contraindications
|
hypersensitivity to murine proteins, known active infection, CHF (if > 5mg/kg), coadministration with anakira (IL-1 antagonist)
|
|
|
Sx assoc with infliximab (remicade) infusion reaction
|
HA, Nauseau, Dyspnea, Injection site infilration, taste abnormalities, <1% with serious sx
|
|
|
Infections assoc with infliximab (remicade)
|
reactivation of TB, pneumocystis, histoplasmosis, reactivation of HepB
|
|
|
Infliximab (remicade) hepatotoxicity
|
Acute Liver Failure (can be fatal), jaundice, cholestasis, autoimmune hepatitis (assoc with ince anti-SMC Ab)
|
|
|
Infliximab (remicade) dosing schedule
|
3-5 mg/kg IV at week 0, 2, 8 and then q 8 weeks
|
|
|
Adalimumab (Humira) Contraindications
|
known hypersensitivity to drug, concurrent administration with anakira, latex allergy (needle cover for Humira has latex)
|
|
|
Autoimmune Rxn assoc with anti-TNF therapy
|
~10-15% get +ANA, some with drug-induced lupus that resolves with d/c of drug
|
|
|
Adalimumab (Humira) hematologic side effects
|
decr WBC, neutrophils, platelets; incr hct, lymphocyte %
|
|
|
adalimumab (Humira) and infliximab (remicade) monitoring guidelines
|
baseline: CBC, PPD, ANA?; monitoring: CBC, LFT q3-4 mos
|
|
|
Adalimumab (Humira) dosing schedule
|
80 mg SQ then 40 mg next week and every other week thereafter
|
|
|
Decreases adalimumab (Humira) clearanc
|
MTX decr humira clearance by 40%
|
|
|
Alefacept (amevive) dosing
|
15 mg IM qweek times 12 weeks, if not better, may repeat another 12 weeks
|
|
|
Infliximab (remicade) halflife
|
7 days at 5 mg/kg; 9 days at 10 mg/kg
|
|
|
Efalizumab (Raptiva) dosing and route
|
1 mg/kg SQ per week
|
|
|
Alefacept (amevive) structure and target
|
Dimeric Fc fusion protein of LFA-3 which binds CD2 of Tcells blocking their costimulatory signals
|
|
|
possible disease assoc with children that have multipe digital myxoid cysts
|
juvenile RA
|
|
|
ANA pattern and autoAb assoc with mixed connective tissue disease
|
ANA particulate pattern; anti-U1RNP
|
|
|
Ab assoc with procainamide-induced SLE-like syndrome
|
leukocyte specific ANA
|
|
|
Lupus subtype assoc c speckled ANA
|
Rowell's syndrome (Lupus-EM like syndrome)
|
|
|
Ab pattern assoc with Rowell's syndrome (Lupus-EM like syndrome)
|
ANA speckled pattern; anti-La (SSB); RF
|
|
|
HLA type assoc with SCLE
|
DR3, B8
|
|
|
Most common ANA pattern in patients SLE
|
homogenous or diffuse pattern
|
|
|
Diseases associated psoriasis
|
Hep C; celiac disease; lymphoma; metabolic syndrome
|
|
|
Drugs assoc with seb derm like eruptions
|
Neuroleptics (haloperidol), Arsenic, Gold
|
|
|
Drugs assoc with psoriasis
|
B-blockers, Lithium, antimalarials (erythrodermic flares), terbinafine, CCB, captopril, glyburide, GCSF, IFN, Lipid lowering drugs
|
|
|
Enbrel (Etanercept) structure and ligand
|
dimeric Fc fusion protein of p75 TNFR which binds soluble TNFalpha and TNFR of Tcells, also binds TNF-beta (lymphotoxin alpha)
|
|
|
Enbrel (Etanercept) half-life
|
4.8 days
|
|
|
Enbrel (Etanercept) morphology change
|
none (transition to erythrodermic or pustular)
|
|
|
Enbrel (Etanercept) tachyphylaxis
|
none with restarting
|
|
|
Enbrel (Etanercept) neutralizing Ab
|
none
|
|
|
Enbrel (Etanercept) rebound
|
None after discontinuing drug
|
|
|
Enbrel (Etanercept) and anakira (IL-1 antagonist) association
|
increased risk of serious infections
|
|
|
Enbrel (Etanercept) mechanism of metabolism
|
proteolysis, no known renal, hepatic or p450 interactions
|
|
|
Defect in EB Simplex, Koebner type
|
Keratin 5, 14
|
|
|
Defect in EB Simplex with muscular dystrophy
|
Plectin
|
|
|
Virus associated with hydrops fetalis
|
parvovirus B19
|
|
|
Etiologic agent in ecthyma gangrenosum
|
Pseudomonas Aeruginosa
|
|
|
Type of Amyloid deposited in nodular primary cutaneous amyloidosis
|
AL fibrils
|
|
|
Histologic alteration of the elastic fibers in pseudoxanthoma elasticum
|
calcification of the elastic fibers
|
|
|
lab abnormality most suggestive of an underlying myeloproliferative disorder in pts with sweet's syndrome
|
anemia
|
|
|
Most common primary malignancy in a woman with cutaneous metastasis
|
Breast
|
|
|
vascular neoplasm associated with POEMS syndrome
|
glomeruloid hemangioma
|
|
|
Pigment abnormality associated with hypomelanosis of Ito
|
linear streaks and whorls
|
|
|
hypomelanotic lesions associated with tuberous sclerosis
|
hypomelanotic guttate macules; "Ash leaf spots"
|
|
|
Cause of Mee's lines
|
arsenic exposure
|
|
|
Classic eye finding in Waardenburg's Syndrome
|
heterochromic irides
|
|
|
enzyme deficiency in erythropoietic protoporphyria
|
ferrochelatase
|
|
|
enzyme deficiency in hepatoerythropoietic porphyria
|
Uroporphyrinogen decarboxylase
|
|
|
enzyme deficiency in porphyria cutanea tarda
|
Urogen decarboxylase
|
|
|
enzyme deficiency in acute intermittent porphyria
|
porphobilinogen deaminase
|
|
|
Defect in Cockayne Tourraine Syndrome
|
Type VII collagen; hyperplastic variant of dominant dystrophic EB
|
|
|
Clinical features of Lofgren's syndrome
|
Sarcoid assoc syndrome with erythema nodosum, migratory polyarthritis, Fever, Iritis
|
|
|
Disease associated with Romana's sign
|
American trypanosomiasis (Chagas' disease): Reduvid bug bite on or near eye leading to periorbital edema and conjunctivitis
|
|
|
Follicular Tumor associated with Rombo syndrome
|
trichoepitheliomas
|
|
|
mode of transmission in Sparganosis
|
ingestion of larvae of the genus spirometra
|
|
|
Etiologic agent of Trichinosis and mode of transmission
|
Trichinella Spiralis and ingesion of cysts
|
|
|
Clinical features of Blau Syndrome
|
Sarcoid assoc with micropapules, arthritis and uveitis
|
|
|
Sensitizing antigen associated with theophylline
|
ethylenediamine
|
|
|
agent and vector of Loa Loa
|
Filarial nematode = Loa Loa; Vecor = Tabaniz flies, Chyrsops Silacea and Chyrsops Dimidiata
|
|
|
Neoplasm most commonly associated with Florid cutaneous papillomatosis
|
gastric carcinoma
|
|
|
Agent associated with Exanthema Subitum
|
AKA Roseola infantum, Sixth diseas: HHV 6, 7
|
|
|
Agent associated with Erythema Infectiosum
|
Aka Fifth disease: Parvovirus B19
|
|
|
Histologic features of a dermoid cyst wall
|
Lined with a stratified epithelium containing various skin appendages including hair follicles, sebaceous lobules, cartilage
|
|
|
Clinical features of Heerfordt-Waldensrom syndrome
|
Sarcoid associated with fever, parotid enlargment, facial nerve palsy
|
|
|
dermatophytes that cause endothrix infection
|
Trichophytons Tonsurans, Violaceum, Schoenleinii, Soudanense, Yaoundei, Gourvilli
|
|
|
Fruit that can cause allergic contact dermatitis in patients allergic to poison ivy
|
Mango Peel
|
|
|
Tumors associated with Kasabach-Merritt syndrome
|
Giant capillary hemangioma, Kaposiform hemangioendothelioma
|
|
|
Osteodysplasia associated with basal cell nevus syndrome
|
Calcification of the falx cerebri
|
|
|
Diseases associated with acquired angioedema
|
Lymphoproliferative disorders: B-cell lymphoma, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, Monoclonal gammopathy
|
|
|
Antigen associated with disulfiram
|
Thiurams
|
|
|
Antigen chemicals found in permanent wave products
|
Alkaline - ammonium thioglycolate. Acid - glycerol thioglycolate. Sulfite - sodium sulfite.
|
|
|
Most common form of Leishmaniasis to be acquired in Texas
|
Cutaneous leishmaniasis caused by L. mexicana
|
|
|
Pregnancy category of topical tretinoin
|
C
|
|
|
Preservative in Eucerin
|
Kathon CG
|
|
|
DIF deposition pattern in neonatal pemphigus
|
Intraepidermal IgG (neonates born to mothers with pemphigus vulgaris)
|
|
|
Maximum recommended dose of 1% plain lidocaine
|
5mg/kg up to a maximum of 300mg (~30cc for 70kg adult)
|
|
|
Causes of Terry's nails
|
Cirrhosis, CHF, adult onset diabetes
|
|
|
Bone abnormality associated with Ehlers Danlos
|
Occipital exostoses ("horns")
|
|
|
Adverse reaction: Leg ulcers
|
Drug: Hydroxyurea
|
|
|
Adverse reaction: Sticky skin
|
Drug: Doxorubicin
|
|
|
Adverse reaction: Photo-onycholysis
|
Drugs: Mercaptopurine, doxycycline
|
|
|
Adverse reaction: Dermatomyositis like eruption
|
Drug: Hydroxyurea
|
|
|
Dental abnormality in Tuberous Sclerosis
|
Dental pits
|
|
|
Application of heat is the preferred method of treatment for infiltration of which chemotherapeutic class?
|
Vinca alkaloids
|
|
|
Depth and composition of a salicylic acid peel
|
Very superficial; Beta-hydroxy acid
|
|
|
Things stained by PAS/diastase
|
Fungi: wall of organism. Glycogen: red, clears with diastase digestion. Basement membrane: pink/red. Cryglobulins: pink/red.
|
|
|
Tattoo pigment associated with phototoxic reactions
|
Cadium sulfide
|
|
|
Most important factors in controlling for depth of a glycolic acid peel
|
pH of the glycolic acid solution & time applied to the skin
|
|
|
Cutaneous side effect associated with dactinomycin
|
Acneiform sterile folliculitis
|
|
|
Cytokine induced by Aldara
|
Interferon-alpha
|
|
|
Depth and components of Jessner's peel
|
Very superficial (stratum corneum/granular layer. Resorcinol. Salicylic acid, Lactic acid, EtOH.
|
|
|
Most common drugs associated with drug-induced pemphigus
|
Penicillamine, captopril, penicillin
|
|
|
Stains for calcium
|
VonKossa - black. Alizarin red - orange/red
|
|
|
Treatment of Lyme disease in a 7 yr old
|
Amoxicillin
|
|
|
Depth and composition of a Resorcin peel
|
Very superficial. Resorcinol
|
|
|
Things detected by Giemsa stain
|
Mast cell granules. Acid mucopolysaccharides. Myeloid granules. Leishmania parasites.
|
|
|
Disease associated with Virchow cells?
|
Lepromatous leprosy
|
|
|
Disease associated with Asteroid bodies
|
Sporotrichosis
|
|
|
Enzyme defect in Variegate porphyria
|
Protoporphyrinogen oxidase
|
|
|
Desmoplakin is a homologue of which other basement membrane protein?
|
BP Ag1
|
|
|
Wong Dermatomyositis
|
Dermatomyositis with clinical features of PRP
|
|
|
TH1 cytokines
|
IFN-gamma, IL-1, IL-12
|
|
|
Variant of atrophoderma of Pasini/Pierini that follows lines of Blaschko?
|
Linear atrophoderma of Moulin
|
|
|
Two clinical subtypes of childhood dermatomyositis
|
1) Brunsting: slow progressive weakness, steroid responsive. 2) Banker: rapid onset of severe weakness, vasculitis of muscles and GI tract, steroid Unresponsive, high death rate.
|
|
|
Branch of facial nerve for Corrugator supercilli muscle
|
Temporal
|
|
|
Branch of facial nerve for Nasalis muscle
|
Zygomatic
|
|
|
Branch of facial nerve for Procerus muscle
|
Zygomatic
|
|
|
Branch of facial nerve for Risorius muscle
|
Buccal
|
|
|
Branch of facial nerve for Zygomaticus major
|
Buccal
|
|
|
Red spectrum lasers and wavelengths
|
1) Qswitch Alexandrite - 755nm. 2) Qswitch Ruby (pulsed) - 694nm. 3) Argon pumped red dye (continuous) - 630nm.
|
|
|
Blue spectrum lasers and wavelengths
|
1) Argon (continuous) - 488nm.
|
|
|
First line treatment for Bacillary Angiomatosis
|
Erythromycin or doxycycline
|
|
|
Wavelength and clinical uses of the Qswitch ruby?
|
694nm. Epidermal & dermal pigment; Nevus of Ota; Black, blue, or green tattoo; Hair removal.
|
|
|
Green spectrum lasers and wavelengths
|
1) KTP (rapid pulsed) 532nm. 2) Argon (continuous) - 514nm. 3) Flash lamp pumped green-dye (short-pulsed) - 504nm.
|
|
|
Best antibiotic for Nocardia
|
Sulfamethoxazole
|
|
|
Things stained with Veerhoff Von Gieson
|
Elastic fibers - black
|
|
|
HLA type most commonly associated with psoriasis with arthritis
|
HLA - B27
|
|
|
Eye structure most at risk from the Erb-YAG laser
|
Cornea - High water content which is the main target for ther Erbium-YAG laser (2900 nm)
|
|
|
Enzyme defect in Hepatoerythropoietic porphyria
|
Uroporphyrinogen decarboxylase
|
|
|
Pathogenic abnormality in Chediak-Higashi
|
Defective melanin synthesis and melanosome transfer
|
|
|
Nerve to block for anesthesia of the posterior earlobe
|
Greater auricular
|
|
|
Things stained by Giesma
|
Mast cells -> metachromatically purple. Leishmania -> blue
|
|
|
Things stained by Prussian blue
|
Hemosiderin, iron -> black
|
|
|
Innervation of eccrine sweat glands
|
Cholinergic sympathetic nerves
|
|
|
First line treatment for Gonorrhea
|
Ceftriaxone
|
|
|
Type of UV protection with PABA and PABA derivatives
|
PABA, Padimate O -> block UVB
|
|
|
Nerve to block for anesthesia of the posterior helix
|
Lesser occipital
|
|
|
Hair abnormality in arginosuccinicaciduria
|
Brittle hair with trichorrhexis nodosa
|
|
|
Disease with Russell bodies
|
Rhinoscleroma. Russel body = Plasma cells grossly distended with proteinaceous products
|
|
|
Gene defect in Erythrokeratoderma variabilis
|
Connexin 31
|
|
|
Disease with Donovan bodies
|
Granuloma inguinale. Donovan bodies = small intracytoplasmic inclusion bodies within macrophages
|
|
|
P450 inducers
|
Carbemazepine, rifampin, phenytoin, phenobarbitol
|
|
|
Medication assoc with increased growth of eyelashes
|
Interferon
|
|
|
Gene defect in Ehlers Danlos syndrome, classic type
|
Col5A1, Col5A2
|
|
|
Type of toxin produced by the Black Widow spider (Lactrodectus)
|
alpha-lactrotoxin
|
|
|
Causative organism and classic exposure for Erysipeloid
|
Erysipelothrix rhusiopathiae, Gram + rod. Fisherman, butcher -> people who handle raw fish, poultry, or meat
|
|
|
Rheumatologic condition that can be precipitated by terbenafine
|
Subacute cutaneous lupus erythematosus
|
|
|
HLA type most closely associated with psoriasis
|
HLA-Cw6 ("psoriasix")
|
|
|
HLA type most commonly associated with pustular psoriasis
|
HLA - B27
|
|
|
Synonym and clinical features of Sneddon syndrome
|
Idiopathic livedo reticularis with systemic involvement. -Widespread patchy livedo reticularis. - Arterial disease in cerebral, coronary, and renal vessels.
|
|
|
Bone abnormality associated with McCune-Albright syndrome
|
Polyostotic fibrous dysplasia
|
|
|
CNS abnormality seen in Sturge-Weber syndrome
|
Double contoured "railroad track" calcifications of the brain.
|
|
|
Desmoglein 3 molecular weight
|
130KDa
|
|
|
First sign of possible lidocaine overdose
|
Circumoral numbness and tingling
|
|
|
DIF deposition pattern in Henoch-Scholein purpura
|
Perivascular IgA
|
|
|
Substance that causes cora-red fluorescence in Erythrasma
|
Coproporphyrin III
|
|
|
Disease associated with Calabar swellings
|
Firm painless swelling assoc with migration of LoaLoa in the skin
|
|
|
Antigen Target of Anti-Jo1 antibodies
|
Histidyl t-RNA synthetase
|
|
|
Antigen associated with purpuric contact dermatitis
|
Para-phenylenediamine (test question), Cobalt, benzoyl peroxide, epoxy resin, methyl metacrylate, EMLA
|
|
|
Pigmentary Abnormality Associated with Amiodarone
|
Blue-Gray discoloration of the malar region
|
|
|
UV-type and timing of delayed tanning
|
UVB/Persists for 48-72 hours
|
|
|
List the diseases associated with the following pigment abnormality: 1) Whorled hyperpigmentation 2) Reticulated pigmentation of flexures 3) Segmented cafŽ au lait macule 4) Reticulated acropigmentation 5) Speckeled macule
|
1) Incontinentia pigmenti (Bloch-Sulzberger) 2) Dowling-Degos 3) McCune-albright 4) Kitamura's Syndrome 5) Carney's
|
|
|
Pathogenic Mechanism in Waardenburg Syndrome
|
Failure of melanoblasts to migrate and differentiate
|
|
|
Pathogenic Mechanism in Piebaldism
|
Decreased malnocyte number or density/deformed malanosomes
|
|
|
Lesion associated with "cayenne pepper" spitted plaque of the glans penis
|
Plasma cell balanitis (Zoons)
|
|
|
Disease associated with macroglossia and periocular petichiae that develop after straining
|
Amyloidosis (light chain disease)
|
|
|
Antibody associated with mixed connective tissue disease
|
Anti-RNP
|
|
|
Wavelength of Erbium-YAG
|
2900nm
|
|
|
Protein associated with secondary amyloidosis
|
Serum protein A-related protein
|
|
|
Gene mutation in Nonbullous Congenital Ichthyosiform Erythroderma
|
Transglutaminiase
|
|
|
Chemical antigen found in garlic
|
Furocoumarin
|
|
|
Etiologic agent and mode of transmission in Dracunculiasis
|
Dracunculus Medinensis/ Ingestion of larvae
|
|
|
Cross reacting antigen in patients with photosensitivity to piroxicam
|
May react to thiosalicylic acid, a common sensitizer of thimerosol
|
|
|
Congenital infections associated with extramedullary hematopoiesis
|
Rubella, cytomegalovirus, parvovirus B19, toxoplasmosis
|
|
|
HPV types associated with flat warts and flat warts in epidermodysplasia verruciformis
|
3, 10, 28, 49
|
|
|
Foods that cross-react with latex
|
Bananas, avocado, kiwi, chestnut, passion fruit
|
|
|
Most common initial skin sign of tuberous sclerosis
|
Hypopigmented ashleaf macules
|
|
|
Type of lipid that is doubly refractile using polarized light
|
Cholesterol esters
|
|
|
Absence of the thymic shadow on CXR is associated with which syndrome?
|
Severe combined immunodeficiency (SCID)
|
|
|
Most common cause of blindness in Behcet's disease?
|
Posterior uveitis
|
|
|
Disease associated with Necrolytic Migratory Erythema
|
Glucagonoma
|
|
|
Subcellular component of peripheral pattern ANA
|
Nuclear membrane
|
|
|
Mechanism of action of azathioprine
|
Inhibition of purine biosynthesis
|
|
|
Enzymes in heme synthesis located in the mitochondrion
|
ALA synthetase, Coprogen oxidase, protogen oxidase, ferrochelatase
|
|
|
Enzyme deficiency in hereditary Coproporphyrin
|
Coproporphyrinogen III oxidase
|
|
|
What is the predominant lipid component of the stratum corneum?
|
Ceramides
|
|
|
Classic eye finding associated with cicatricial pemphigus
|
symblepharon
|
|
|
Exposure associated with burning marine grade (pressure treated) wood
|
Arsenic
|
|
|
Agent in papular purpuric glove and sock syndrome
|
Parvovirus B19, also others = measles, coxsackie, hep B, HSV, CMV, EBV
|
|
|
Wavelength most efficient at forming pyrimidine dimers in skin
|
290-310nm
|
|
|
Depth and components of glycolic peel
|
alpha-hydroxy acid, very superficial
|
|
|
Enzyme deficincy in variegate porphyria?
|
Protoporphyrinogen oxidase
|
|
|
Most common tumors associated with nevus sebaceous?
|
1. Syringocystadenoma papilliferum 2. Trichoblastoma
|
|
|
Bone x-ray abnormaility in basal cell nevus syndrome (Gorlin's)
|
Bifid Rib
|
|
|
Drug associated with elastosis perforans serpiginosa
|
Penicillamine
|
|
|
Technical name of vitamin E
|
Alpha-tocopherol
|
|
|
Vitamin deficiency associated with phrynoderma (trad skin)
|
Vitamin A
|
|
|
Nail abnormality associated with lichen planus
|
Pterygium
|
|
|
Nail abnormality associated with Nail-Patella syndrome
|
Triangular lunula
|
|
|
Gene + inheritence in Hailey-Hailey
|
1. Autosomal dominant 2. Gene = ATP2C1 ATP-dependent calcium pump that plays a role in cell-cell adhesion
|
|
|
Gene in EBS with muscular dystrophy
|
Plectin
|
|
|
Mechanism of green hair discoloration in swimmers
|
Copper deposition
|
|
|
Preferred laser for treatment of hirsutism in dark skin tones
|
Long-pulse Nd-YAG (1064 nm) dermal melanin is the target chromophore
|
|
|
Enzyme deficiency associated with endogenous ochronosis
|
Homogentisic acid oxidase
|
|
|
Body part relatively apred in Gianotti-Crosti syndrome
|
Trunk
|
|
|
Keratins predominantly expressed by basal keratinocytes
|
Keratin 5, 14
|
|
|
Prophylactic therapy of choice in patients with frequent attacks of hereditary angioderma
|
Danazol
|
|
|
Structure and target of Efalizumab (Raptiva)
|
Humanized monoclonal IgG Ab against the CD11a subunit of LFA-1
|
|
|
Risk of developing neutralizing antibodies with Adalimumab
|
About 5% chance of developing low titer neutralizing antibodies
|
|
|
Neurologic adverse events associated with Infliximab
|
Demyelinating neurologic disease
|
|
|
Structure of Infliximab (Remicade)
|
Chimeric (25% mouse) IgG against TNF alpha binds soluble and cell surface TNF alpha
|
|
|
Systemic signs of salicylate toxicity
|
tinnitus, acute confusion, refractory hypoglycemia (especially in DM and patients with decreased renal function)
|
|
|
Predominant cytokine patteren in psoriasis
|
Elevated TH1 cytokines (IL-2, -6, -8, 12, IFN gamma, TNF alpha)
|
|
|
HLA-type most commonly associated with pustular psoriasis
|
HLA-B27
|
|
|
Woronoff's Ring
|
Conentric blanching of the erythematous skin at or near the periphery of a healing psoriatic plaque oten 1st sign of a response to phototherapy
|
|
|
Clinical features of keratoderma blennorrhagicum (Reiter Syndrome)
|
Psoriasis (thicker keratotic lesions), develop disease after a bout of urethritis of enteritis
|
|
|
HLA-type most commonly associated with keratoderma blennorrhagicum (Reiter Syndrome)
|
HLA-B27
|
|
|
Clinical features of impetigo herpetiformis
|
Generalized pustular dermatitis of pregnancy, flexural erythema studded with pustules initially which progresses to a generalized pustular flare
|
|
|
HLA type most commonly associated with psoriatic arthritis
|
HLA-B27
|
|
|
CD34 staining in NFD versus morphea
|
NFD - CD34 positive; Morphea = loss of CD34 dermal cells
|
|
|
Diseases associated with mutations in keratin 17
|
PC II and steatocystoma multiplex
|
|
|
Antigen Target of Anti-Jo1 antibodies
|
Histidyl t-RNA synthetase
|
|
|
Antigen associated with purpuric contact dermatitis
|
Para-phenylenediamine (test question), Cobalt, benzoyl peroxide, epoxy resin, methyl metacrylate, EMLA
|
|
|
Pigmentary Abnormality Associated with Amiodarone
|
Blue-Gray discoloration of the malar region
|
|
|
UV-type and timing of delayed tanning
|
UVB/Persists for 48-72 hours
|
|
|
List the diseases associated with the following pigment abnormality: 1) Whorled hyperpigmentation 2) Reticulated pigmentation of flexures 3) Segmented cafŽ au lait macule 4) Reticulated acropigmentation 5) Speckeled macule
|
1) Incontinentia pigmenti (Bloch-Sulzberger) 2) Dowling-Degos 3) McCune-albright 4) Kitamura's Syndrome 5) Carney's
|
|
|
Pathogenic Mechanism in Waardenburg Syndrome
|
Failure of melanoblasts to migrate and differentiate
|
|
|
Pathogenic Mechanism in Piebaldism
|
Decreased malnocyte number or density/deformed malanosomes
|
|
|
Lesion associated with "cayenne pepper" spitted plaque of the glans penis
|
Plasma cell balanitis (Zoons)
|
|
|
Disease associated with macroglossia and periocular petichiae that develop after straining
|
Amyloidosis (light chain disease)
|
|
|
Antibody associated with mixed connective tissue disease
|
Anti-RNP
|
|
|
Wavelength of Erbium-YAG
|
2900nm
|
|
|
Protein associated with secondary amyloidosis
|
Serum protein A-related protein
|
|
|
Gene mutation in Nonbullous Congenital Ichthyosiform Erythroderma
|
Transglutaminiase
|
|
|
Chemical antigen found in garlic
|
Furocoumarin
|
|
|
Etiologic agent and mode of transmission in Dracunculiasis
|
Dracunculus Medinensis/ Ingestion of larvae
|
|
|
Cross reacting antigen in patients with photosensitivity to piroxicam
|
May react to thiosalicylic acid, a common sensitizer of thimerosol
|
|
|
Congenital infections associated with extramedullary hematopoiesis
|
Rubella, cytomegalovirus, parvovirus B19, toxoplasmosis
|
|
|
HPV types associated with flat warts and flat warts in epidermodysplasia verruciformis
|
3, 10, 28, 49
|
|
|
Foods that cross-react with latex
|
Bananas, avocado, kiwi, chestnut, passion fruit
|
|
|
Most common initial skin sign of tuberous sclerosis
|
Hypopigmented ashleaf macules
|
|
|
Type of lipid that is doubly refractile using polarized light
|
Cholesterol esters
|
|
|
Absence of the thymic shadow on CXR is associated with which syndrome?
|
Severe combined immunodeficiency (SCID)
|
|
|
Most common cause of blindness in Behcet's disease?
|
Posterior uveitis
|
|
|
Disease associated with Necrolytic Migratory Erythema
|
Glucagonoma
|
|
|
Subcellular component of peripheral pattern ANA
|
Nuclear membrane
|
|
|
Mechanism of action of azathioprine
|
Inhibition of purine biosynthesis
|
|
|
Enzymes in heme synthesis located in the mitochondrion
|
ALA synthetase, Coprogen oxidase, protogen oxidase, ferrochelatase
|
|
|
Enzyme deficiency in hereditary Coproporphyrin
|
Coproporphyrinogen III oxidase
|
|
|
What is the predominant lipid component of the stratum corneum?
|
Ceramides
|
|
|
Classic eye finding associated with cicatricial pemphigus
|
symblepharon
|
|
|
Exposure associated with burning marine grade (pressure treated) wood
|
Arsenic
|
|
|
Agent in papular purpuric glove and sock syndrome
|
Parvovirus B19, also others = measles, coxsackie, hep B, HSV, CMV, EBV
|
|
|
Wavelength most efficient at forming pyrimidine dimers in skin
|
290-310nm
|
|
|
Depth and components of glycolic peel
|
alpha-hydroxy acid, very superficial
|
|
|
Mechanism of action of topical calcineurin inhibitors (Tacrolimus, pimecrolimus)
|
Tac + Macrophilin-12 (FK-BP)->inh. Calcineurin (Ca activ. Phosphatase)->inh NFAT dephos->no nuclr translocn->decr. prdxn inflam cytokines
|
|
|
Pt. with allergy para-aminobenzoic acid most likely to cross-react w/ which type anesthetic?
|
Ester "caines" = tetrac., benzocaine, cocaine, procaine, proparacaine
|
|
|
Most common skin tumor in patients with NF2
|
Schwannoma
|
|
|
Gene for X-linked ichthyosis
|
Steroid sulfatase
|
|
|
Most common pattern of arthritis in psoriasis?
|
Asymmetrical oligoarthritis
|
|
|
Best suture for running intradermal closure
|
Prolene (polypropylene)
|
|
|
Things stained with Warthin-Starry
|
Spirochetes and Rochalimacea (stain black)
|
|
|
Most common autoimmune condition seen in pts with Hep C
|
Autoimmune thyroiditis
|
|
|
Disease associated w/ pigmentary disorder: Reticulated acropigmentation?
|
Ktamura's Syndrome
|
|
|
Disease associated w/ pigmentary disorder: Speckled macule
|
Carney syndrome
|
|
|
Classic skin lesions in sitosterolemia
|
Eruptive xanthomas (it's a rare d/o that lead to accumulation of plant sterols=sitosterol in blood
|
|
|
Regional anesthesia of the plantar foot requires injection of which nerves
|
femoral, that's right Andrew
|
|
|
Syndrome associated with renal angiomyolipomas
|
tuberous sclerosis
|
|
|
Clothing type most likely to cause allergic contact derm in a formaldehyde allergic patient
|
Polyester-cotton blend
|
|
|
Antigen for allergic contact derm to opthalmic solutions
|
Thimerosol
|
|
|
Chemical antigon associated with nail polish
|
Toluene sulfonamide formaldehyde resin
|
|
|
Rickettsial pox: Agent and vector?
|
Rickettsia akari; vector=house mouse mite=liponyssoides sanguineus
|
|
|
Trench fever: agent and vector?
|
Rickettsia (Bartonela) quintana; vector=human louse=pediculosis humanis corporis
|
|
|
RMSF: agent and vector?
|
R. rickettsia; vectors= 1.Wood tick=dermacantor andersoni, 2.dog tick=d.variabilis,3.lone start tick=amblyomma americanum)
|
|
|
Epithelial lining associated with bronchogenic cysts
|
Pseudostratified columnar with cilia
|
|
|
Epithelial lining associated with Median Raphe cyst
|
Pseudostratified columnar; transitional type
|
|
|
List eye finding c/w:1.Marfans 2.Waardenburg 3.Ehlers-Danlos 4.Homocysteinuria 5. Refsum
|
1.Ectopic lentis-upward 2.Heterochromatic irides 3.Keratoconus 4.Ectopic-lenstis-down 5.Retinitis pigmentosa
|
|
|
Active ingredient in "sun free" tanning products?
|
Dihydroacetone
|
|
|
Gene in EDS hypermobility type
|
Tenascin X
|
|
|
Adverse reaction c/w cooadministration of itraconazole & cisapride
|
Ventricular arhythmias (Torsades). Azole -> inhbit CYP 3A4-> incr levels cisapride
|
|
|
Agent and vector for Afriacan trypanosomias (Sleep sickness)?
|
W. Africa: Trypanosoma brucei gambience; E. Afr: trypanosoma brucei Rhodesense; vector=tsetse fly
|
|
|
Agent and Vector for Q Fever
|
R.ickettsia burnetti; trasmit by inhaking dry tick feeces.
|
|
|
Clinical features of Watson Syndrome
|
Variant of tye I NF, multiple CALMs, pulmonic stenosis, short starture, dull intelligence
|
|
|
Agent and Vector of trench fever
|
Rickettsia (bartonella) quintana; Vector = human body louse
|
|
|
Anti-inflammatory mechanism of Dapsone
|
Inhibition of the halide-myeloperoxidase system that normally produces reactice hypochlorite ions
|
|
|
What does Alizarin Red S stain?
|
Calcium
|
|
|
DIF deposition pattern of chronic bullous disease of childhood
|
Linear IgA at DEJ
|
|
|
Protein associated with hemodialysis related amyloidosis
|
Beta-2 microglobulin
|
|
|
Characteristic panniculitis-associated change associated with lupus erythematosus
|
lymphoid follicles
|
|
|
Pigmented skin lesion associated with melanin macroglobules
|
CafŽ au lait macules
|
|
|
Vitamin that can be used to treat retinoid-associated chelitis
|
Vitamin E (alpha-tocopherol)
|
|
|
Co-administration of erythromycin and which drug can cause cardiotoxicity
|
Cisapride (toxicity=arrythmias)
|
|
|
Skin diseases associated with hep C?
|
PCT, essential mixed cryoglobulinemia, lichen planus, PAN
|
|
|
Antigen of Krazy glue
|
Ethyl cyanoacrylate
|
|
|
Bone abnormality in Osteogenesis Imperfecta
|
Kyphoscoliosis
|
|
|
Antigen chemical associated with artifical nails
|
hahaha it's 2 things! 1. adhesive: cyanoacrylate 2.nails: methyl methacrylate
|
|
|
hair defect in uncombable hair sx?
|
pili trianguli et canniculi
|
|
|
hair defect in Mene's Kinky Hair sx?
|
pili torti (most common), trichorrhexis nodosa, monilethrix, hair ressembles steel wool
|
|
|
Disease w/ Mikulicz cells?
|
Rhinoscleroma
|
|
|
Pathognomonic eye finding in Vit A deficiency?
|
discrete plaques of keratinizing epithelium on the conjunctival surfaces=Xerosis Conunctivae Bitot Spots
|
|
|
Type monoclonal gammoathy a/w erythema elevatum diutinum
|
IgA (most common)
|
|
|
Microscopic hair finding in trichothidystrophy
|
Alternating birefringence w/ polarization
|
|
|
Abx most likely to decrease efficacy of OCP
|
rifampin
|
|
|
Most common paraprotein seen in pts with pyoderma gangrenosum?
|
IgA
|
|
|
Organism causing Erosio interdigitalis Blastomycetica?
|
Candida albicans
|
|
|
Gene a/w Herediatry Hemorrhagic Telangectasia (Osler-Weber-Rendu Sx)
|
Endoglin=TGF-binding protein in endothelial cells
|
|
|
Which cell type generates mucin in digital mucous cyst
|
fibroblast
|
|
|
Antigen a/w allergic contact derm to Black henna tattoos?
|
Paraphenylenediamine
|
|
|
Malignancy most commonly a/w primary systemic amylodosis
|
multiple myeloma
|
|
|
Endocrine abnormality a/w langerhans cell histiocytosis
|
diabetes insipidus
|
|
|
Joint abnormalit a/w multicentric reticulohistiocytosis
|
mutilating arthritis
|
|
|
Vitamin deficiency a/w Casal's Necklace
|
niacin (pellagra)
|
|
|
Nutrient deficiency a/w alternating hair color bands (flag sign)
|
Kwashiorkor (protein and essential AA deficiency)
|
|
|
Ellectrolyte abnormality seen in sq fat necrosis of newborn
|
hypercalcemia
|
|
|
Wavelenth of UVA
|
320-400 (320-340=UVA2, 340-400=UVA1)
|
|
|
Tooth abnormality a/w hyper-IgE sx?
|
retention of primary teeth
|
|
|
Cause fo Muehscke's Lines
|
paired white bands that parallel the lunula cuz of hypoalbuminemia or chemothx
|
|
|
cause of onychomadesis
|
Beau's lines=any physiologic stressor eg fever, surgery, stress
|
|
|
classic eye finding in refsum's
|
Retinitis pigmentosa (salt and pepper retina)
|
|
|
Subcellular target in nucleolar ANA
|
RNA
|
|
|
subcellular target in speckled ANA
|
ribonucleoprotein
|
|
|
medications classically a/w fixed drug eruption
|
NSAIDs, sulfonamides, barbiturates, tetracycline, laxatives (phenopthalein), pseudoephedrine
|
|
|
gene mutation in Bloom sx
|
BLM gene (a DNA helicase)
|
|
|
Enzyme defect in congenital erythropoetic porphyrin (CEP) or Gunter's disease
|
Urogen III synthase
|
|
|
type of prophyrin w/ AR inheritance
|
Congental erythr. Porphyrin
|
|
|
Disease a/w pili torti and sensorineural deafness
|
Bjornstand's Syndrome
|
|
|
TH2 cytokines
|
IL-4, IL-5
|
|
|
Max dose of 1% lido with epi (1:100,000)
|
7mg/kg
|
|
|
Which systemic antifungal is a photoallergen
|
griseofulvin
|
|
|
Drug most commonly a/w neutrophilic eccrine hidradenitis
|
Ara-C
|
|
|
Mechanism Botox
|
blocks releace of Acetylcholine from pre-synapti terminal of Neuromuscular jnx
|
|
|
Agent and vector in epidemic typhys
|
Rickettsia Prowazekii, vector= human body louse (Pediculus humanus corporis
|
|
|
Genes a/w Tuberous Sclerosis
|
TSC1=Hamartin; TSC2= Tuberin
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Rheumatoid nodulosis
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variant of rheumatoid disease, multiple ulcerated cutaneous nodules, high RF, w/o destructive joint dz
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Rheumatoid arthritis assoc skin d/o
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erythema elevatum diutinum, PG, felty syndrome, IgA vasculitis, Linear IgA dz, Sjogren's syndrome, BP, yellow nail syndrome
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Lymphoproliferative dz a/w Sjogren's
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Waldenstrom benign hypergammaglobulinemia purpura
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Antibody a/w predominance of lupus-like clinical features in MCTD
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anti-TSI-RNA antibody
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DIF finding w/ mixed connective tissue dz
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particulate epidermal nuclear IgG deposition
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Exposure a/w punctate palmoplantar keratoderma
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dioxin exposure
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EM findings in progressive symmetric erythrokeratodermia
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loricrin-rich intranuclear granules and swollen mitochondria in the granular cell layer
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Inheritance and gene for progressive symmetric erythrokeratodermia
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AD w/ incomplete penetrance; gene is loricrin
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EM finding in erythokeratoderma variabilis
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markedly decreased # of odland bodies in granular layer
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Schopf-Schulz-Passarge syndrome
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palmoplantar keratoderma w/ SCC arising in areas affected by keratoderma
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Huriez syndrome
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palmoplantar keratoderma w/ sclerodactyly
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Keratoderma features in epidermolytic PPK
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symmetric, well-demarcated, diffuse keratoderma of the palms and soles; non-transgradients; erythematous border; +/- hyperhidrosis; +/- painful blisters
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3 clinical variants of keratosis pilaris atrophicans
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ulerythema ophryogenes; atrophaderma vermiculata; keratosis follicularis spinulosa decalvans
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Conditions potentially a/w ulerythema ophyogenes
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Noonan's syndrome; Wooly hair; cardiofaciocutaneous syndrome; cornelia de lange syndrome; rubinstein-taybi syndrome; atopy
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Clinical features of IFAP syndrome
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IFAP = Ichthyosis Follicularis w/ Alopecia (Atrichia) and Photophobia; non-inflammatory folliculuar hyperkeratosis, ichthyosis, non-scarring alopecia, photophobia
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Most common cause of Phrynoderma (toad skin)
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Vit A deficiency
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Gene and inheritance in Sjogren-Larssen syndrome
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AR, gene = fatty aldehyde dehydrogenase
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Gene and inheritance in Nethertons
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AR, gene = SPINK5
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Gene and inheritance of Ichthyosis Bullosa of Siemens
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AD, gene = Keratin 2e
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EM finding in BCIE (bullous congenital ichthyosiform erythroderma)
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intracytoplasmic epidermal inclusions due to both aggregated keratin filaments and enlarged keratohyalin granules
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testicular findings in x-linked ichthyosis
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undescended testes (25%), increased risk therefore of testicular cancer
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Immunohistochemical marker for Ki-67 lymphoma
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CD-30
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Local anesthetics with the longest duration of action
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bupivicaine, etidocaine
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Microscopic hair abnormality in loose anagen syndrome
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Thickened or ruffled cuticle
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HLA-type assoc with Behcets
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HLA-B51
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What type of tumor is a sclerosing hemangioma
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Variant of a dermatofibroma
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Microscopic hair abnormality in monilothrix
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Beaded hairs
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Defective kertinocyte enzyme in clear cell acanthoma
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decreased phosphorylase
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Genoderm assoc with pulmonary lymphangioleiomyomatosis in women of child bearing age
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Tuberous sclerosis
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Deficiency in pellagra
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Niacin
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Etiology of Aldrich-Mees lines (transverse white bands)
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Arsenic and other trace element intoxications
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Skin cancers assoc with Muir-Torre syndrome
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Sebaceous tumors (adenomas, epitheliomas, carcinomas) and keratoacanthomas
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Electrolyte abnormality assoc with pustular psoriasis
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Hypocalcemia
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Screening required in children less than 2 years old with multiple cutaneous juvenille xanthogranulomas
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Eye exam for occular involvement by JXG
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Disease assoc with pigmentary abnormality - reticulated pigmentation of the flexures
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Dowling-Degos disease
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Things stained by Von-Kossa
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Calcium (black)
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Disease assoc with pigmentary abnormality - segmental cafŽ au lait
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McCune-Albright
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Food that can cause a phototoxic reaction from psoralens in grocery handlers
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celery
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Antibody assoc with drug-induced lupus
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anti-histone antibodies
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CNS neoplasm most commonly assoc with Gorlin's syndrome (basal cell nevus syndrome)
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Medulloblastoma
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Cancer most commonly assoc with Birt-Hogg-Dube syndrome
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Renal cell carcinoma
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Vitamin deficiency assoc with phrynoderma (toad skin)
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Vitamin A
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Disease name for eponym Dercum's disease
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Adiposa dolorosa
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Type of toxin produced by the Brown recluse spider (Loxosceles)
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Sphingomyelinase-D
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Time to give prophylactic antibodies with surgery
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0-2 hours before surgery
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Technical flap type of a nasolabial flap
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Transposition
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Bilobe flap is which type of technical flap
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Transposition
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Type of porphyria with normal urine porphyrins
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Erythropoietic protoporphyria
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Patients with dermatomyositis and positive anti-Jo1 antibodies are at increased risk of
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Pulmonary fibrosis
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Skin manifestations of Hartnup disesae mirror those seen with a deficiency in
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Niacin (pellagra like skin changes in Hartnup)
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