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77 Cards in this Set

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Vitamins are..
ORGANIC compounds essential in the diet to promote GROWTH AND MAINTENANCE
Water soluble Vitamins
B VITAMINS
VITAMIN C

not stored in body in large amounts
Fat soluble Vitamins
ADEK

captured in micelle
enrichment
the process of adding nutrients back to foods that have lost nutrients due to processing

thiamin, niacin, riboflavin, folic acid, iron
fortification
the process of adding nutrients to foods that are not generally found in food
vitamin absorption
must be absorbed to perform functions

40-90% of vitamins are absorbed in the small intestine
provitamin
vitamin precursor forms that must be converted into active forms by the body
Vitamin Functions (6)
energy metabolism from macronutrients

make red blood cells

bone health

protein metabolism

immune function

growth and development
Free Radicals
can cause damage to DNA and cell membrane

unmatched electric charge; unbalanced
Antioxidants
neutralize free radicals
RDA and AI
recommended amount of vitamins necessary to prevent deficiencies and promote health
UL
to avoid toxicities
Divided based on..
age
gender
lifestage
Thiamin
First B vitamin discovered
-deficiency condition in asia related to diet change from brown rice to polished rice
Thiamin Functions (4)
- transmission of nerve impulses
- coenzyme for metabolism of glucose and certain amino acids for energy
- neurotransmitters
- plays role in breakdown of alcohol in the body
beriberi
thiamin deficiency
symptoms: fatigue, weakness
depression, poor coordination, paralysis
Wernicke- Korsakoff
thiamin deficiency associated with alcohol abuse

progressively damaging brain disorder
Riboflavin (b2)
major food source: milk
is light sensistive

can cause urine to turn bright yellow
Riboflavin Functions (3)
-important for energy metabolism of carbohydrates, fats, and proteins to energy
- enhances functions of other B vitamins such as niacin and B12
- keeps cells healthy
kelosis
riboflavin deficiency is tissue cells with rapid turnover

sore around edges of mouth

lining of mouth, tongue, and eyes
niacin (b3)
consumed from foods or made from tryptophan
niacin functions (3)
-coenzyme for energy metabolism from carbohydrates, fat, protein
- synthesis of fat and cholesterol
- maintaining health of skin cells and digestive system
UL of Niacin
35 mg/day

flushing, nausea, vomiting
may be toxic to liver

may be perscribed in high doses by physicians to lower LDL cholesterol and triglycerides, increase HDL
Pellagra
niacin deficiency disease
4 D's: dermatitis, diarrhea, dementia, death
dermatitis
skin rash
Vitamin B6
functions as coenzyme for over 100 enzymes in protein metabolism needed for:
- to create nonessential amino acids
- conversion of tryptophan to niacin
- to break down of glycogen for glucose
- create hemoglobin in red blood cells
B6 UL
100 mg/day to prevent nerve damage

excessive amounts through supplements may result in nerve damage
B6 Deficiency
poor growth, skin lesions, poor immune response, numbness or tingling in extremities, mycrocytic anemia

Supplementation may improve immune function
Folate
naturally occurring form in foods
Folic acid
synthetic form of folate added to foods and supplements

absorbed more easily than folate

vital for pregnant women
600 micrograms
400 micrograms from fortified foods/ supplements
plus 200 micrograms naturally occuring
Folate/ Folic Acid Functions (4)
amino acids metabolism,
related to creation and maintenance of new cells,
vital for DNA synthesis, particularly important for rapidly dividing cells

may reduce risk of colon, pancreatic, breast, ovarian cancer
Folate Food Sources
broccoli
asparagus
green leafy vegetables
legumes
enriched grains ie pasta, bread, cereal
macrocytic anemia
Folate deficiency
can lead to formation of abnormally large, immature red blood cells

dont divide because they cant make DNA
Folate Deficiencies in pregnant women
neural tube birth defects
such as: spina bifida
anencephaly
Spina bifida
incomplete development of brain, spinal cord and/or spine
anencephaly
incomplete development of brain, skull, scalp
Folate UL
1000 micrograms/day

too much folate can mask a B12 deficiency anemia
Folate Deficiencies
macrocytic anemia
nerve damage
Vitamin B12
AKA cobalamine (contains cobalt)

only water soluble vitamin stored in the body in significant amounts

only found in animal products (not including supplements)
Vitamin B12 Functions(6)
-DNA synthesis
-energy production from certain fatty acids
-maintain healthy nerves and cells, especially red blood cells
- maintain myelin coating on nerves
-conversion of homocysteine to methione
-may protect from heart disease with folate and b6
atrophic gastritis
decrease of stomach acid production

may be cause to ability to absorb naturally occuring b12 from food declines with age
B12 Deficiency
-macrocytic anemia
-pernicious anemia

nerve damage (irreversible)
numbness
gait abnormalities
disorientation
Biotin Functions
coenzyme for energy metabolism and glucose synthesis

metabolism of fatty acids and amino acids
Biotin Function
coenzyme for energy metabolism and glucose synthesis

metabolism of fatty acids and amino acids
Biotin Sources
cooked eggs, liver, yogurt, nuts

also synthesized by bacteria in G.I.
Biotin Deficiency
nausea, thin hair, rash on skin, depression, lethargy

raw eggs contain AVIDIN which BINDS biotin
Vitamin C
AKA "ascorbic acid"

smokers accelerate breakdown and elimination from body
Vitamin C Toxicity
can cause nausea, stomach cramps, diarrhea

caution in people with a history of kidney stones or hemochromatosis (body stores to much iron)
Scurvy
vitamin c deficiency
condition characterized by swollen and bleeding gums, rough rash on skin, coiled or curly arm hairs, wounds that wouldnt heal
Fat Soluble Vitamins
require fat and bile for absorption

once absorbed transported to lymph system

can be stored in body fat:
reduced fats of deficiencies
increased risk of toxicities
Vitamin A
2 forms found in food:
preformed vitamin A
provitamin A
Preformed Vitamin A
retinoid family: retinol, retinal, retinoic acids

ready for your body to use
only found in animal products
SOURCES: liver, eggs, fortified milk and cheese
Provitamin A
carotenoids

precursor to active form
plant based foods
-orangish pigment that provide color for plants

converted to retinol in your body

includes beta-carotene

SOURCES:carrots, spinach, green leafy vegetables, sweet potatoes
Vitamin A functions
essential for healthy eyes

involved in cell differentiation, reproduction and immunity by promoting gene expression for:
-white blood cells to fight harmful bacteria and keeping skin healthy to act as barrier
-healthy skin
-mucus membranes
-bone growth
-fetal development
Vitamin A UL
preformed
excessive intake:
-liver deterioration
-osteoporosis and increased risk of fractures
-during pregnancy, may lead to birth defects

provitamin
built in mechanism to prevent conversion to retinol if consumed in excess

smokers who supplemented had a higher incidence of lung cancer
Vitamin A Deficiency
caused by lack of vitamin a, fat, protein, or zinc

associated with stunting of bones
night blindness
chronic vitamin a deficiency
xerophthalmia
prolonged vitamin deficiency

can cause permanent damage to cornea

can cause of preventable blindeness in children, mostly in developing countries
Vitamin D
"sunshine vitamin"

produced by skin by exposure to UV light

sunexposure cannot meet everyones vitamin D needs

needs increase as we age

activated in kidneys
Vitamin D Sources
liver, fatty fish, fish oils, egg yolk
Vitamin D Functions
active form acts as hormone

regulation of Ca and P

stimulates intestinal absorption of Ca and P

help maintain bone health
Vitamin D and Parathyroid Hormone (PTH)
causes calcium to leave bones to increase blood levels
Vitamin D: other potential benefits
may prevent type 2 diabetes
and cancers (breast, ovarian, colon, prostate)

may reduce risk of type 1 DM hypertension (high blood pressure) multiple sclerosis
Vitamin D deficiencies
weakening of bone

rickets: only in children
osteomalacia: only in adults
Vitamin D toxicities
supplements: 100 micrograms/day

may result in high amounts of calcium in blood and urine

may deposit in blood vessels and kidneys, cardiovascular damage and possibly death
Vitamin E
"Alpha-tocopherol"- most active form in body
Vitamin E Functions
-acts as a powerful antioxidant
-protects cell membranes, prevents oxidation of LDL cholesterol
-studies continue on potential protective effect with heart disease
- acts as a coagulant, inhibiting formation of harmful clots within the blood stream
Vitamin E deficiency
rare
nerve problems, muscle weakness, and free radical damage to cell membrane
vitamin E UL
only in supplements
can cause hemorrhage
risk of prostate cancer
Vitamin K
two forms:
menaquione
phylloquinone
menaquinone
synthesized by intestinal bacteria
phylloquinine
found in green plants
Vitamin K functions
-important to bone health
-essential for blood clotting
-involved in synthesizing four blood clotting factors
Vitamin K Deficiency
severe and extremely rare
may affect blood clotting
Vitamin K UL
none known

people taking anitcoagulant medications such as warfarin (Coumadin) need to keep vitamin k intake cosistent

changes can increase/decrease drugs effectiveness
Dietary Supplements
-can be another source of vitamins in modern diet
-can contain some combos of vitamins, minerals, herbs, botanicals, amino acids, enzymes, or extracts.
-cannot replace the benefits of a diet containing a wide variety of foods
Those who would benefit from supplementation
-those on weight loss diet of less than 1600 cal//day
-those who do not consume milk or dairy
-dietary restrictions due to health conditions
-vegans and some other vegetarians
-older adults
-young women and pregnant women