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33 Cards in this Set

  • Front
  • Back
cytoskeleton generates force by what 2 mechanisms?

what type of migration is a combo of both of these mechanisms?
-assembly/disassembly of cytoskeletal polymers
-cytoskeletal motor proteins

-whole cell migration
at which domain does the motor protein attach to the cargo?
tail domain
the force is in the (same/different) direction to the movement of the motor protein itself
movement of motor proteins is ...
3 major families of motor proteins
-...-plus-end directed motors
-...-plus-end directed motors
-...-minus end directed motors
which 2 families of motor proteins oppose each other?
Kinesins and dyneins
myosin is involved with ... filament-based motility
kinesins and dyneins are involved with ...-based motility
do motor proteins bind to intermediate filaments?
which type of myosin is this?
-1 head and 1 short tail
-moves in plus end direction
-collaboration among multiple myosin heads to move membranes
-participates in endocytosis
-found in microvilli
myosin I
what type of myosin is this?
-muscle myosins and cytoplasmic myosins
-2 heads and coiled-coil tail
-arrangement of tails into bipolar filaments that generates an opposite polarized action (muscle contraction, cytokinesis, cell crawling)
myosin II
what type of microtubule-based motility plays a main role in organelle transport and mitotic separation?
-steps towards positive end
what type of microtubule-based motility carts organelles towards the negative direction?

-the ... or motor domain has sites for ATP hydrolysis and cytoskeletal polymer binding

-involved in retrograde transport of ER vesicles to golgi

-necessary to move chromosomes towards mitotic spindle

... is the cyclic attachment/detachment coupled to ATP hydrolysis and conformational change

-Both heads start with ADP. once head in front binds to microtubule, it releases ADP and ATP binds in its place. This creates a swinging around of the back head towards the plus end. Then that head binds to the microtubule, releases its ADP while the back head hydrolyzes ATP to ADP, and the process continues!
kinesin walking
whole cell movement (crawling) is actin filament-myosin based motility or microtubule-motor protein based motility?
actin filament-myosin based motility
ciliary and flagellar motility and cytoplasmic membranous organelles are actin filament-myosin based motility or microtubule-motor protein based motility?
microtubule-motor protein based motility
name which type(s) of intracellular motility each one has:
-intracellular transport
-positioning of organelles (homeostasis is the 1 exception)
-microtubule-based and actin filament-based
what type of movement of membrane-bound particles goes towards the periphery of a cell (away from cell center?
what type of movement of membrane bound particles goes towards the center of the cell?
retrograde movement
kinesin molecules transport cargo via ... transport (towards positive end)
dynein molecules transport cargo via ... transport (towards negative end)
the plus end of the microtubules are towards the cell body or axon terminal?
axon terminal
the minus end of the microtubules are towards the cell body or axon terminal?
cell bodies
kinesin is bound to the ... and pulls to the periphery of cell (plus direction)
dynein binds to membrane of ... and pulls to the center of the cell (minus direction)
golgi apparatus
Cell motility
-cilia and flagella are ... based
-whole cell movement (crawling) is ... based
actin filament
these are functions of what 2 things?
-move cells through liquid medium (swimming)
-move fluid, mucus or cells along surface of ciliated epithelium
-... are necessary for assembly of axoneme
-arranged in '...' array
-... generates the sliding force
basal bodies
if adjacent microtubules were linked, as is the case in the axoneme (in flagellum), the linking proteins would convert the usual sliding motion into a ... motion
Kartagener's syndrome (alson known as immobile cilia syndrome) is one of a larger group of disorders known as ...
-defect in the inner dynein arms of the axoneme
-clinical manifestations: innefective mucocilliary clearance and immotile spermatozoa
primary ciliary diskinesia (PCDs)
when cells move towards a positive signal, it's called ...
Whole cell movement steps (crawling):
-extension of leading edge is driven by ...
-adherence to underlying substrate occurs due to adhesion molecules called ... (bridge)
-contraction of the rear (tail end of cell)
actin polymerization
the leading edge moves in a ... movement