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41 Cards in this Set
- Front
- Back
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NO, O3, SO2, Cl2, hydrocarbons, CN, NH3, cadmium, Hg
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contribute to obstructive pulmonary disease
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pneumoconisoses
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non-neoplastic lung disease
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pneumoconisoses produced by
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inhalation of inorganic dusts or aerosols
coal dust, silica, beryllim |
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insoluble dust
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produces fibrosis (mediated by macrophages)
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black lung disease
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coal workers pneumoconiosis
inhalation of coal dust produces macules = fibrosis |
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silicosis
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caused by quartz or talc
produces silicotic nodules throughout lung 1.5x increase in risk for lung cancer |
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abestosis
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produces diffuse interstitial fibrosis over decades
pleural plaques are common increase in risk for lung carcinomas |
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mesothelioma
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neoplasm seen only with asbestos exposure
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chronic berylliosis
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multiple granulomas resembling sarcoidsos
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acute berylliosis
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hypersensitivity pneumonitis
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hypersensitivity pneumonitis
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inflammation of the alveoli due to inhaled organic dusts
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extrinsic allergic alveolitis
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produced by organic dusts
features of type 3 hypersensitivity (type 4 if chronic) rarely fibrosis |
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asthma
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ass w inhalation of cotton fibers (byssinosis), wood dusts
polyurethane, dyes |
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radon gas
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second most common cause of lung cancer
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fomepizole
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alcohol dehydrogenase inhibitor to treat MeOH poisoning
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cocaine causes
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ischemic heart disease or malignant hypertermia
coronary vasoconstriction, thrombosis, acc atherosclerosis |
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lead
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demyelinating injury to neurons esp in children
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arsenic + mercury
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cause neuropathy
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organophosphates
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acetyl-cholinesterase inhibitors
parathion, malathion |
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organophosphates produce
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paralysis, arrhythmia, respiratory failure
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asbestos causes
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mesothelioma
bronchogenic carcinoma GI carcinoma |
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nickel causes
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nasopharyngeal + lung carcinomas
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arsenic causes
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carcinomas of skin, lung, liver
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hydrocarbons cause
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bladder carcinoma, leukemia
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nitrites cause
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gastric carcinoma
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vinyl chloride causes
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hepatic angiosarcoma
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hepatic angiosarcoma
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malignant tumor of breast + skin originating from bv
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tissue damage due to radiation causes
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direct hits on DNA produce mutations
production of free radicals (therapeutic radiation) |
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cells sensitive to radiation
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germ cells in testis/ovary
bone marrow + GI tract lining |
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strontium-90
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in cow's milk = gets into bones of humans
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200-300 rads
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bone marrow failure
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50-100 rads
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GI symptoms
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500+ rads
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convulsions, coma, death
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partial thickness burns (2nd degree)
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skin adnexa
can regenerate |
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full thickness burns (3rd degree)
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no epithelial cells left
requires grafting |
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burn injury complications
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fluid loss
sepsis |
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hypothermia
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exposure to cold
core body temp less than 35C |
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hyperthermia
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prolonged exposure to a hot environment
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heat cramps
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muscle cramps
treat with gatorade |
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heat exhaustion
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cardiovascular collapse
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heat stroke
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mult organ failures as core temp rises above 40.6
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