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25 Cards in this Set
- Front
- Back
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P40scc
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sidechain cleaving; cholesterol --> pregnenolone
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HMG-CoA reductase
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acetyl CoA --> cholesterol
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3B-HSD
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delta5 --> delta4; pregnenolone --> progesterone; DHEA --> androstenedione
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17B-HSD
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ketone --> hydroxyl; androstenedione --> testosterone; estrone --> estradiol
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5alpha-reductase
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removes double bound; testosterone --> DHT
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P450c11
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hydroxyl on C11; progesterone --> cortisol OR corticosterone
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P450aldo
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add aldehyde; corticosterone --> aldosterone
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p450aro
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aromatize A ring; androstenedione --> estrone; testosterone --> estradiol
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convertase
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cleave inactive fragment; prohormone --> active peptide/hormone
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tyrosine hydroxylase
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add hydroxyl; tyrosine --> DOPA
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DOPA decarboxylase
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remove carboxylic acid; DOPA --> dopamine
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dopamine beta-hydroxylase
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add hydroxyl; dopamine --> norepinephrine
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PNMT
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add methyl group; norepinephrine --> epinephrine
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MAO (monamine oxidase)
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degrade catecholamines (intraneuronal, local neuroglia)
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COMT (catechol-O-methyl transferase)
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degrade catecholamines (nearby neuroglial cells)
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cyclooxygenase
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arachidonic acid --> prostaglandins (blocked by aspirin)
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SBG
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plasma binding protein for T, DHT, & E2
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CBG
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plasma binding protein for glucocorticoids & some progesterone (NOT aldosterone!)
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StAR
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allows cholesterol to enter mitochondria
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TPO
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adds iodine & couples tyrosines; tyrosine --> MIT, MIT --> DIT, DIT --> T4)
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outer ring deiodinase
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removes iodine from outer ring; T4 --> T3
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inner ring deiodinase
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removes iodine from inner ring; T4 --> rT3
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alpha2-globulins
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plasma binding protein for T3/T4
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prealbumin (transthyretin, TTR)
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plasma binding protein for T3/T4
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albumin
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plasma binding protein for T3/T4 (loosely)
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