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16 Cards in this Set
- Front
- Back
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Where can Sertoli cells be found and what do they form?
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In the seminiferous tubules. Tight junctions btwn adjacent cells form the blood-testis barrier.
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What 2 hormones stimulate Sertoli cells?
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FSH: grow and secrete spermatogenic substances
TST: strong trophic effect |
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What is the main function of Sertoli cells?
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Support spermatogenesis.
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What are androgen binding proteins (ABP)?
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They are synthesized by the Sertoli cells under FSH stimulation. They allow the local accumulation of TST.
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What stimulates the release of LH and FSH from the anterior pituitary?
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GnRH, released by the hypothalamus.
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What are 5 general functions of androgens?
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1.Regulate release of hormones from ant. pituitary and hypothalamus
2.Support of spermatogenesis 3.Regulation of sexual behavior 4.Development of the male phenotype 5.Sexual maturation |
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What is the effect of LH on Leydig cells?
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Stimulates TST production. Also exerts a trophic effect and is req'd for maintenance of cell function
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Where do Leydig cells reside?
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In the interstitium of the testes, scattered in the CT surrounding each tubule
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Where is inhibin produced? What does it do?
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It is produced in the Sertoli cells and acts on the ant. pituitary to inhibit FSH release.
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What other hormones does TST regulate and how?
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It inhibits the release of GnRH from the hypothalamus, the release of LH from the ant. pituitary, and to a small degree the release of FSH from the ant. pituitary
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What is the mitotic status of Sertoli cells?
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They are post-mitotic and unable to divide.
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What are 4 effects of FSH on Sertoli cells?
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1.Induces P450 aromatase
2.Cell proliferation (during devlopment and before puberty) 3.Stimulates synthesis of inhibin 4.Stimulates synthesis of ABP |
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What is the function of Leydig cells?
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Production of steroid hormones, namely TST
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What are 2 things that can happen to TST in the periphery?
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1.Conversion to DHT by 5-a reductase
2.Conversion to estradiol by aromatase |
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What is DHT?
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It has similar effects to TST, but at a different magnitude.
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What happens to TST in the Sertoli cells?
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Some remains local by binding ABP, some is converted to estradiol by P450 aromatase.
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