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13 Cards in this Set

  • Front
  • Back
How does ESRD affect the endocrine system?
Feedback mech's
Hormone Prod
Hormone Transport
Hormone Metabolism and Elimination
What endocrine organs are affected by CKD
Pituitary
Gonads
Diabetes
Bones (metabolic bone disease)
CKD and Growth?
-GH is elevated
-Growth is retarded in kids w/ CKD despite normal GH levels
-Rx w/ GH restores growth velocity
-Transplant does not always restore growth velocity
PRL and CKD?
PRL is elevated (dec clearance)

Gynecomastia
Impotence
Amenorrhea
Male Gonadal Hormones and CKD?
Testosterone Decreases
LH Inc
FSH Inc
Result of male gonadal dysfxn from CKD?
Dec Libido
Impotence
Testicular Atrophy
Infetility
Female Gonadal Hormones and CKD?
Inc LH:FSH ratio
Loss of mid-cycle LH and FSH surges
Sx's of CKD related to gonadal hormones?
Dec Libido
Amenorrhea
Infertility
Diabetes and CKD?
reduced insulin clearance leading to inc risk of hypoglycemic episodes
Why do you get HypoCa w/ CKD?
Inc Phosphate Retention (binds to Ca)
Altered Vit D metabolism (dec 1,25)
Skeletal Resistance to PTH
Three Components of Renal HyperPTH?
Hypocalcemia
Altered Ca-regulated PTH secretion
Reduced Clearance of PTH
Long-term affect of Renal HyperPTH on parathyroid glands?
After being "on" for so long they can't turn "off" = Tertiary HyperPTH
Sx's of Tertiary HyperPTH?
Pseudoclubbing...i.e. the tips erode away
Calcifalaxis
Kyphosis
Sternal Buckling