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18 Cards in this Set
- Front
- Back
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sympathetic: long or short pre ganglionic neurons
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short
postganglionics are long EXCEPT BRAG: bladder, reproductive, adrenals and GI |
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parasympathetic: preganglionic nn short or long
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long
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CNS nn release what onto what R
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Ach onto N1 R
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what do sympathetic preganglionics release and onto what R?
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Ach onto N2 R, parasympathetics do the same, so they are both cholinergic
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what do parasympathetic postganglionics release and onto what R?
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they release Ach onto muscarinic or nicotinic R
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sympathetic postganglionics release what onto what type of R
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epi or NE onto alpha and beta R (adrenergic)
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N1 receptors,
location agonist antagonist |
N1 receptors,
location - target organ of CNS neuron agonist - Ach and nicotine antagonist - curare and norcuron "can't stand" |
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N2 receptors,
location agonist antagonist |
location - postganglionic nn
agonist - Ach nicotine antagonist - trimethaphan and hexamethonium |
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M1 R
location agonist antagonist signalling pathway |
location - between neurons
agonist - Ach and muscarine antagonist - Atropine signalling pathway - Galphaq: IP3/DAG |
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M2 R
location agonist antagonist signalling pathway |
location - heart
agonist - Ach and muscarine antagonist - atropine signalling pathway - Gi, decrease cAMP |
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M3 R
location agonist antagonist signalling pathway |
location - smooth muscle
agonist - Ach and muscarine antagonist - atropine signalling pathway -Galphaq IP3/Dag |
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alpha R in general
location agonist antagonist |
location - throughout body
agonist: NE antagonist: phentolamine |
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alpha1 R
agonist antagonist signalling pathway |
agonist - phenylephrine(NE)
antagonist - prazosin (phentolamine) signalling pathway - Galphaq - IP3/DAG |
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alpha2 R
agonist antagonist signalling pathway |
agonist: clonidine
antagonist: (phentolamine) signalling: Gi decrease cAMP |
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Beta receptors in general
agonist signalling pathway |
agonist- Epi and isoproterenol
signalling - Galpha-s increase cAMP |
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beta1 R
location antagonist |
location - heart
antagonist - propranolol |
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beta2 R
location antagonist |
location - smooth muscle
antagonist - propranolol and atenolol |
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beta3 R
location antagonist |
location - adipocytes
antagonist- carazolol |
