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18 Cards in this Set

  • Front
  • Back
sympathetic: long or short pre ganglionic neurons
short
postganglionics are long
EXCEPT BRAG: bladder, reproductive, adrenals and GI
parasympathetic: preganglionic nn short or long
long
CNS nn release what onto what R
Ach onto N1 R
what do sympathetic preganglionics release and onto what R?
Ach onto N2 R, parasympathetics do the same, so they are both cholinergic
what do parasympathetic postganglionics release and onto what R?
they release Ach onto muscarinic or nicotinic R
sympathetic postganglionics release what onto what type of R
epi or NE onto alpha and beta R (adrenergic)
N1 receptors,
location
agonist
antagonist
N1 receptors,
location - target organ of CNS neuron
agonist - Ach and nicotine
antagonist - curare and norcuron

"can't stand"
N2 receptors,

location
agonist
antagonist
location - postganglionic nn
agonist - Ach nicotine
antagonist - trimethaphan and hexamethonium
M1 R
location
agonist
antagonist
signalling pathway
location - between neurons
agonist - Ach and muscarine
antagonist - Atropine
signalling pathway - Galphaq: IP3/DAG
M2 R
location
agonist
antagonist
signalling pathway
location - heart
agonist - Ach and muscarine
antagonist - atropine
signalling pathway - Gi, decrease cAMP
M3 R
location
agonist
antagonist
signalling pathway
location - smooth muscle
agonist - Ach and muscarine
antagonist - atropine
signalling pathway -Galphaq IP3/Dag
alpha R in general
location
agonist
antagonist
location - throughout body
agonist: NE
antagonist: phentolamine
alpha1 R

agonist
antagonist
signalling pathway
agonist - phenylephrine(NE)
antagonist - prazosin (phentolamine)
signalling pathway - Galphaq - IP3/DAG
alpha2 R

agonist
antagonist
signalling pathway
agonist: clonidine
antagonist: (phentolamine)
signalling: Gi decrease cAMP
Beta receptors in general
agonist
signalling pathway
agonist- Epi and isoproterenol
signalling - Galpha-s increase cAMP
beta1 R
location

antagonist
location - heart

antagonist - propranolol
beta2 R
location
antagonist
location - smooth muscle
antagonist - propranolol and atenolol
beta3 R
location
antagonist
location - adipocytes
antagonist- carazolol