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18 Cards in this Set
- Front
- Back
connection of hypothalamus to anterior pituitary?
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vascular connection
capillary/portal system-->rapid |
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connection of hypothalamus to posterior pituitary?
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Neuronal connection
axon traverses all the way to the posterior pituitary axon terminates on venules |
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2 major hormones released by posterior pituitary?
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ADH
Oxytocin |
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activities of ADH? (there are 3, but 1 is major)
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1) Increase water uptake by kidney
affects collecting duct V2 receptor mediated: Gs – cAMP aquaporin -2 increased synthesis insertion into plasma membrane 2) arterial and venous constriction 3)stimulate ACTH |
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what leads to the release of ADH?
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increase in ECF osmolality
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secretion of oxytocin stimulated by?
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Suckling: spinal cord, spinothalamic tract, brainstem/midbrain, PVN
Estradiol (progesterone withdrawal) Fergusson reflex (female body's response to pressure application in the cervix and/or vaginal walls. Upon application of pressure, oxytocin is released and uterine contractions are stimulated ) |
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activities of oxytocin? 2
mediated by what receptor? |
Lactation
Uterine contractions mediated by a Gq receptor |
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slide 16 is nice for hypothalamic NT and action in anterior pituitary
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feel free to look at it
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how is prolactin released?
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tonic inhibition by dopamine from hypothalamus
must relieve it this leads to prolactin release from pituitary |
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FEEDBACK LOOPS ON 17
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if you do this now it could save you time later... your call
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GH is very pulsitile, what allows it to have an extended effect?
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there are high and low affinity binding proteins in circulation that extend the half life
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major function of GH?
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Stimulates linear growth (directly and indirectly via IGF-1) (IGF 1 is what actually leads to the growth)
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somatostatin is a peptide hormone that is cleaved and has activity in both the GI and brain...what is its activity?
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Inhibits release of
GH, PRL, and TSH from pituitary Insulin and glucagon from pancreas Secretions from enteroendocrine cells |
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draw the feedback loop for ACTH
including the pituitary cell, trophic hormone, target organ, target hormone, and action |
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draw the feedback loop for TSH
including the pituitary cell, trophic hormone, target organ, target hormone, and action |
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draw the feedback loop that starts with GnRH
including the pituitary cell, trophic hormone, target organ, target hormone, and action |
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draw the feedback loop that starts with GHRH
including the pituitary cell, trophic hormone, target organ, target hormone, and action |
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Draw the feedback loop for prolactin
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